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Mechanism and control of transposition of two line-like mobile elements of drosophilia melanogaster, the I factots and the F elements

Objective



We are interested in a class of mobile elements known as LINES which, although they are not structurally related to retroviral-like elements, transpose by reverse transcription of an RNA intermediate.
We want to study the molecular mechanism of the transposition process and its control by using two LINE-like elements of Drosophila melanogaster. They are the I factors that are involved in the determination of the I-R system of hybrid dysgegenesis, and the F elements.

We shall try to determine the coding sequences of the I factor that are involved in the control of its activity. We shall also identify the Drosophila genes coding for products interacting with I element sequences. A fraction of these genes are expected to modify, when mutated, the phenotype of mutant alleles due to I element insertions. We shall study the properties of the F. element when introduced into another species and compare the structure of its promoter to that of the I factor.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Address
Avenue De La Terrasse, Bftiment 26
91198 Gif Sur Yvette
France

Participants (3)

NATIONAL RESEARCH COUNCIL OF ITALY
Italy
Address
Via Guglielmo Marconi 10
80125 Napoli
UNIVERSITY OF EDINBURGH
United Kingdom
Address
King's Building, Darwing Building, Mayfield Road
EH9 3Jr Edinburgh
Université de Clermont-Ferrand I (Université d'Auvergne)
France
Address
28 Place Henri-dunant
63001 Clermont-ferrand