Objective
We are interested in a class of mobile elements known as LINES which, although they are not structurally related to retroviral-like elements, transpose by reverse transcription of an RNA intermediate.
We want to study the molecular mechanism of the transposition process and its control by using two LINE-like elements of Drosophila melanogaster. They are the I factors that are involved in the determination of the I-R system of hybrid dysgegenesis, and the F elements.
We shall try to determine the coding sequences of the I factor that are involved in the control of its activity. We shall also identify the Drosophila genes coding for products interacting with I element sequences. A fraction of these genes are expected to modify, when mutated, the phenotype of mutant alleles due to I element insertions. We shall study the properties of the F. element when introduced into another species and compare the structure of its promoter to that of the I factor.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Topic(s)
Data not availableCall for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
91198 GIF SUR YVETTE
France