Objective
A thorough genetic, physiological and molecular characterisation of the genes involved in three pathways of nitrogen utilisation in the fungus Aspergillus nidulans has already been achieved. This has included the sequencing of all regulatory and many of the structural genes concerned with thes pathways. This proposal seeks to dissect, through mutational analysis,
the functional domains of each of the regulatory genes and to establish the possible interactions between the protein encoded by the wide domain regulatory gene area, mediating nitrogen metabolite repression (and thus ensuring preferential utilisation of favoured nitrogen sources), and those
encoded by the specific regulatory genes for each pathway, mediating induction by respective substrates. Moreover, this analysis might shed light on the interactions between these transcription factors and more general components of the transcriptional apparatus.
While the objectives of this proposal relate only to fundamental science, the understanding of the utilisation of nitrogen sources in a model eukaryotic microbe is of obvious practical importance. Furthermore, although this proposal aims to understand the nature of transcriptional complexes in
one model organism, the fact that the specific transcription factors belong to a class of DNA-binding proteins probably restricted to the fungi whilst the wide domain AREA proteins belongs to a group whose origin predates the divergence between fungi and metazoa will shed light on the evolution of the transcriptional apparatus.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences microbiology mycology
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
91405 GOMETZ LA VILLE
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.