Gene expression consequences of the neurogenic signalling in Drosophila

Project Information

Grant agreement ID: SC1*0819

Project closed

Start date 1 December 1992

End date 30 November 1995

Funded under

• Programme plan (EEC) to stimulate the international cooperation and interchange needed by European research scientists (SCIENCE), 1988-1992

Total cost No data

EU contribution No data

Coordinated by

FOUNDATION OF RESEARCH AND TECHNOLOGY - HELLAS
Greece

Objective

Embryonic neurogenesis in Drosophila requires intercellular interactions, mediated in great part by the products of the neurogenic genes, some of which have been accordingly shown to encode transmembrane proteins. Our analysis of E(sp1), one of the neurogenic loci, has shown that it comprises a number of genes, all of which appear to encode nuclear proteins. We are proposing to extend the molecular, genetic and biochemical analysis of the
E(sp1) genes. We specifically plan to document their spatiotemporal patterns of expression by RNA in-situs and by protein immunolocalisation in wild-type embryos as well as ones mutant for potentially interacting genes. The DNA binding ability of one class of E(sp1) proteins, homologous to helix-loop-helix transcription factors, will be assayed. As a broader aim, we shall try
to gain insight on how the neurogenic transmembrane signalling is transduced to the nucleus and how it affects gene expression to generate two distinct types of tissue, nervous and epidermal. We shall try to isolate genes activated as a result of the neurogenic signalling. One approach will involve cloning genes containing DNA binding sites for E(sp1) proteins. Alternatively, we will try to isolate genes turned on as a result of interaction of the two products of neurogenic genes Notch and Delta on the surface of cultured cells.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• natural sciences › biological sciences › genetics › DNA
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• natural sciences › biological sciences › genetics › RNA
• medical and health sciences › clinical medicine › embryology

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Programme(s)

• FP2-SCIENCE - Programme plan (EEC) to stimulate the international cooperation and interchange needed by European research scientists (SCIENCE), 1988-1992

Topic(s)

Data not available

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

FOUNDATION OF RESEARCH AND TECHNOLOGY - HELLAS

• EU contribution: No data
• Address: Vassilika Vouton ; 71110 IRAKLION ; Greece
• Total cost: No data

Participants (3)

UNIVERSITAET BASEL

Switzerland

• EU contribution: No data
• Address: 70,Klingelbergstrasse 70 ; 4056 BASEL
• Total cost: No data

University of Cambridge

United Kingdom

• EU contribution: No data
• Address: Downing Street ; CB2 3DY Cambridge
• Total cost: No data

Universität Hohenheim

Germany

• EU contribution: No data
• Address: Garbenstraße 30 ; 70599 Stuttgart
• Total cost: No data