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MOLECULAR MECHANISMS OF CELL INJURY AND TOXICITY IN MARINE MOLLUSCS

Objective


Considerable progress has been made in understanding the mechanisms of pollutant induced cell injury. This ranges from the direct action of pollutants, their activated metabolites or radicals on biological molecules such as deoxyribonucleic acid (DNA), proteins or membrane components. Disturbances at the molecular and supramolecular (eg membranes) levels lead to organelle and cellular dysfunction and these in turn contribute to tissue and organ impairment and failure of the digestive and reproductive systems.

The findings presented in this report contribute to a mechanistic understanding of the processes of pollutant toxicity and cell injury in an important environmental sentinel organism, namely the marine mussel. Consequently, this enables us to interpret distress signals from these organisms in a more environmentally meaningful way and to start to direct our thinking towards the problems of causal mechanisms, thus strengthening the basis for the use of mussels as sentinels for biological impact.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

NERC Centre of Coastal and Marine Sciences
Address
Prospect Place West Hoe
PL1 3DH Plymouth
United Kingdom

Participants (2)

UNIVERSITE DE BORDEAUX I
France
Address
Cours De La Libération 351
33405 Talence
Università degli Studi di Genova
Italy
Address
Viale Benedetto Xv 3
16132 Genova