Objective Considerable progress has been made in understanding the mechanisms of pollutant induced cell injury. This ranges from the direct action of pollutants, their activated metabolites or radicals on biological molecules such as deoxyribonucleic acid (DNA), proteins or membrane components. Disturbances at the molecular and supramolecular (eg membranes) levels lead to organelle and cellular dysfunction and these in turn contribute to tissue and organ impairment and failure of the digestive and reproductive systems. The findings presented in this report contribute to a mechanistic understanding of the processes of pollutant toxicity and cell injury in an important environmental sentinel organism, namely the marine mussel. Consequently, this enables us to interpret distress signals from these organisms in a more environmentally meaningful way and to start to direct our thinking towards the problems of causal mechanisms, thus strengthening the basis for the use of mussels as sentinels for biological impact. Fields of science natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteins Programme(s) FP1-STIMULATION 1C - Plan (EEC) to stimulate European scientific and technical cooperation and interchange, 1985-1988 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator NERC Centre of Coastal and Marine Sciences Address Prospect place west hoe PL1 3DH Plymouth United Kingdom See on map EU contribution € 0,00 Participants (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITE DE BORDEAUX I France EU contribution € 0,00 Address Cours de la libération 351 33405 Talence See on map Università degli Studi di Genova Italy EU contribution € 0,00 Address Viale benedetto xv 3 16132 Genova See on map
