Objective The Adh region of the Drosophila melanogaster has been characterised. In particular, the physical limits of lethal(2)br22 and nocA, 2 genes which lie distal to Adh, have been defined in greater detail. The limits of lethal(2)br22 have been defined within a 12 kb genomic region by mapping the breakpoints associated with various mutations. The transcripts associated with this region is a 3.0 kb/3.1 kb doublet which is expressed throughout development with maximal levels of accumulation during the later half of embryonic and pupal development. Analysis of cDNA clones corresponding to these mRNA species indicates that they are the products of alternate splicing. DNA sequence analysis has not yet revealed any obvious homologies, but the sequence of the whole of the transcribed region is not yet complete. The expression pattern of the mRNA doublet was examined by in situ hybridization to tissue sections. The results indicate that these mRNAs appear to be expressed out of phase with the engrailed pattern, suggesting the possibility that they may be downstream genes whose expression is regulated by the engrailed product. Fields of science natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesgeneticsmutation Programme(s) FP1-STIMULATION 1C - Plan (EEC) to stimulate European scientific and technical cooperation and interchange, 1985-1988 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator Foundation for Research and Technology-Hellas Address 71110 Heraklion-crete Greece See on map EU contribution € 0,00 Participants (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution € 0,00 Address Trinity lane, the old schools, CB2 1TN Cambridge See on map University of Bristol United Kingdom EU contribution € 0,00 Address Senate house tyndall avenue BS8 1TH Bristol See on map Links Website Opens in new window
