The overall aim of this twinning project is to investigate the mechanisms of catabolite repression control in the life cycle of representative gram negative bacteria. Specific objectives will be:
1) To investigate the regulation of the E. coli adenyl cyclase (cya) gene at the molecular level with particular emphasis on carbon mediated regulation. 2) To investigate the organisation, regulation and role of the genes involved in cAMP synthesis in Rhizobium meliloti. As we have demonstrated that these organisms contain at least two cya like genes, particular emphasis will be placed on the relative comparison of these systems to the situation in enteric bacteria (i.e. collaborative twinning project between Cork and Paris labs specializing in these areas).
3) To investigate the nature of cAMP synthesis control and catabolite repression control in Rhizobium (using hydrogen metabolism (Hup) as a model system) by host plant signals during the plant-microbial symbiotic interaction involving collaboration between Cork, Montepellier, Madrid and Paris).
Funding SchemeCSC - Cost-sharing contracts