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Biomonitoring of human populations exposed to pesticides

Objective

The objective is to develop and apply analytical methods for the identification of populations and individuals exposed to selected pesticides and to evaluate levels of exposure.

This project deals with the development and application of analytical methods to identify people exposed to pesticides (professional exposure) and the evaluation of the levels of their exposures. A range of methodologies, both biological and chemical, will be utilized in order to evaluate the most adequate techniques to be applied in relation to pesticide residues or to their metabolite residues.

Exposed professional groups are identified and analyzed in the regions of Campania (Italy), Liguria (Italy), Maresme (Spain), and Helsinki (Finland). The techniques to be applied or developed, are the following.
Biological methods: chromosome aberrations (CA); sister chromatid exchanges (SCE); micronuclei (MN); poly(adenosine diphosphate (ADP) ribose) polymerase (POL); urine analyses (UA); and cholinesterase.
Chemical methods: deoxyribonucleic acid (DNA) adducts; haemoglobin amino acids adducts; and plasma proteins adducts.

All these techniques are also applied to the model animals groups exposed to pesticides, on which the same effects and the metabolism of some pesticides will be investigated.

Pesticides to be analyzed are; thiocarbamates, dibromoethane, dichloroethane, 1,3-dichloropropene, methylisothiocyanate, methylbromide, atrazine, molinate, organophosphate insecticides, alachlor, Chlordimeform, vinclozolin, amitrole, ethylbromide, ethylene oxide, and methyl parathion. For each one of these pesticides a review of their known toxicological potential will be prepared.

Samples from a group of around 3000 unexposed people already participating in a large biomonitoring programme undertaken during the last 5 years for clinical end points will be analyzed as controls.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

Bio Re Pla Biological Research Planning Sas
Address
Via Damiano Chiesa 5
56123 Pisa
Italy

Participants (11)

Bayerische Julius-Maximilians-Universität Würzburg
Germany
Address
Versbacher Straße
97078 Würzburg
Consiglio Nazionale delle Ricerche (CNR)
Italy
Address
111,Via P. Castellino
80131 Napoli
Consiglio Nazionale delle Ricerche (CNR)
Italy
Address
Città Universitaria Piazzale Aldo Moro 5
00185 Roma
FINNISH INSTITUTE OF OCCUPATIONAL HEALTH
Finland
Address
41 A,topeliuksenkatu 41 A
00250 Helsinki
GSF-Forschungszentrum für Umwelt und Gesundheit GmbH
Germany
Address
Ingolstädter Landstraße 1
85764 Neuherberg
Istituto Nazionale per la Ricerca sul Cancro
Italy
Address
Viale Benedetto Xv 10
16132 Genova
STOCKHOLM UNIVERSITET
Sweden
Address
Svante Arrhenius Vaeg, 12
106 91 Stockholm
UNIVERSIDADE NOVA DE LISBOA
Portugal
Address
93,Rua Da Junqueira 93
1349-008 Lisboa
Universidad Autonoma de Barcelona
Spain
Address
Campus Universitario
08193 Barcelona
Università degli Studi di Genova
Italy
Address
Corso Europa 26
16132 Genova
Université Catholique de Louvain
Belgium
Address
72,Avenue E. Mounier
1200 Bruxelles