Objective
The main aim of the project is to study the transmission dynamics of the S.haematobium group, with particular emphasis being placed upon the ecological and genetic factors determining focal levels of endemicity. Areas selected for the study will be in Mali, Senegal and Zambia.
In Mali, the distribution and epidemiology of schistosomes
within the Schifstosoma haematobium group (S. haematobium and S. intrecalatum) in specified foci will be determined together with factorsinfluencing endemicity levels. Incidence studies will be carried out onpeople post treatment.The application of recently developed serological techniques, particularly CAA and CCA
antigen levels in urine and serum, to determine prevalence and intensity of infections will be compared with more traditional parasitological techniques. A multi disciplinary approach will be used to identify and characterise both the snail intermediate hosts and schistosomes, including morphology (scanning electron microscope studies), enzyme analysis (isoelectric focusing) and DNA probes. Attention will be directed at determining the degree of interaction between S. haematobium and S. intercalatum and the epidemiological significance of such interactions.
In Senegal, studies will be conducted on the epidemiology
of schistosomes of the S. haematobium groupin the Senegal river basin. Children, (5 to 14 years), and to a lesser degree cattle Will be examined to establish levels of prevalence and intensity. Attempts will be made to elucidate whether there is an
interaction between S. haematobium and S. Curassoni Schistosomes and their intermediate hosts will be characterized and compatibility studies will demonstrate host/parasite relationships. In Zambia one area of S. haematobium transmission near
Lusaka will be studied in detail. Emphasis will be placed upon determining prevalence and intensity of infection pre- and post treatment together with studies on snail dynanics and infection. In addition, itis hoped to find outwhether interactions between S. haematobium and S. mattheei exist in Zambia.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health epidemiology
- natural sciences physical sciences optics microscopy electron microscopy
- natural sciences earth and related environmental sciences hydrology drainage basins
- agricultural sciences animal and dairy science domestic animals animal husbandry
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
9000 GENT
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.