Objective The main aim of the project is to study the transmission dynamics of the S.haematobium group, with particular emphasis being placed upon the ecological and genetic factors determining focal levels of endemicity. Areas selected for the study will be in Mali, Senegal and Zambia. In Mali, the distribution and epidemiology of schistosomes within the Schifstosoma haematobium group (S. haematobium and S. intrecalatum) in specified foci will be determined together with factorsinfluencing endemicity levels. Incidence studies will be carried out onpeople post treatment.The application of recently developed serological techniques, particularly CAA and CCA antigen levels in urine and serum, to determine prevalence and intensity of infections will be compared with more traditional parasitological techniques. A multi disciplinary approach will be used to identify and characterise both the snail intermediate hosts and schistosomes, including morphology (scanning electron microscope studies), enzyme analysis (isoelectric focusing) and DNA probes. Attention will be directed at determining the degree of interaction between S. haematobium and S. intercalatum and the epidemiological significance of such interactions. In Senegal, studies will be conducted on the epidemiology of schistosomes of the S. haematobium groupin the Senegal river basin. Children, (5 to 14 years), and to a lesser degree cattle Will be examined to establish levels of prevalence and intensity. Attempts will be made to elucidate whether there is an interaction between S. haematobium and S. Curassoni Schistosomes and their intermediate hosts will be characterized and compatibility studies will demonstrate host/parasite relationships. In Zambia one area of S. haematobium transmission near Lusaka will be studied in detail. Emphasis will be placed upon determining prevalence and intensity of infection pre- and post treatment together with studies on snail dynanics and infection. In addition, itis hoped to find outwhether interactions between S. haematobium and S. mattheei exist in Zambia. Fields of science medical and health scienceshealth sciencespublic healthepidemiologynatural sciencesphysical sciencesopticsmicroscopyelectron microscopynatural sciencesearth and related environmental scienceshydrologydrainage basinsagricultural sciencesanimal and dairy sciencedomestic animalsanimal husbandrynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) FP3-STD 3 - Specific research and technological development programme (EEC) in the field of the life sciences and technologies for developing countries, 1990-1994 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator GENT UNIVERSITY Address 24,casinoplein 24 9000 Gent Belgium See on map EU contribution € 0,00 Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT NATIONAL DE RECHERCHES EN SANTE PUBLIQUE Mali EU contribution € 0,00 Address Bamako See on map LEIDEN UNIVERSITY Netherlands EU contribution € 0,00 Address 62,wassenaarseweg 62 2300 RC Leiden See on map Natural History Museum United Kingdom EU contribution € 0,00 Address Cromwell road SW7 5BD London See on map Région Médicale de St.Louis du Sénégal - Ministère de la Santé Publique et Action Sociale Senegal EU contribution € 0,00 Address 40 Saint louis See on map University of Zambia Zambia EU contribution € 0,00 Address 50110 Lusaka See on map
