Objective
The study will test the existing hypotheses of the molecular-genetic basis of chloroquine-resistance using resistance-diagnostic techniques simply carried out on blood spots collected in the field. Control studies will be carried out on continuous and clones from field isolates.
The drug sensitivity of falciparum malaria in patients in Guinea-Bissau and in Indonesia will be tested in vivo and in vitro. Blood spots on glass fibre discs and cryopreserved isolates will be collected.
Diagnostic probe and polymerase chain reaction (PCR) studies will be carried out on the blood spots to characterize resistance-related genes. The cryopreserved material will be recovered into continuous cultures and clones selected. Probe, PCR and restriction studies will be carried out on the clones, together with drugsensitivity tests for comparison with results obtained on the fresh isolates.
Knowledge of the way in which malaria parasites become resistant will give insights into the mode of action of drugs and enable the development of improved and novel drug entities to attack morbidity and mortality due to the disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases malaria
- social sciences sociology demography mortality
- medical and health sciences health sciences public health epidemiology
- medical and health sciences clinical medicine allergology drug allergy
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC1E 7HT London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.