Objective
The overall objective of this study is to contribute to a better understanding of the potential of vit Aas a therapeutic aid to reduce the severity and mortality of childhood infections (diarrhoeal diseases (DD), cere bral malaria (CM) and acute respiratory infections (ARI)) and to contribute to the formulation, implementation and evaluation of strategies for reducing infant and child mortality in Mozambique.
B. Specific objectives: 1 Determine the contribution of subclinical vit A deficiency to immediate and delayed case-fatality for DD, CM and ARI among hospitalized children with DD, CM and ARI. 2 Test the potential of routine vit A supplementation at admission with regard to survival, complications and recovery during hospitalization for DD, ARI and CM. 3 Determine the outcome of children admitted with DD, ARI and cM in the 6 weeks after discharge. 4T0 compare different methods of assessing subclinical deficiency of vit A
SUMMARY oF THE RESEARCH WORK: The study will be a randomised triple-blind placebo-controlled trial. Three groups of children with either DD or ARI or CM, admitted to the paediatric wards of the CHM with the appropriate criteria will be assigned randomly to a control (receiving a placebo) or a supplementation (receiving vit A) group and will be visited 6 weeks after discharge. All efforts will be done to adhere to current practices regarding criteria for admission or discharge. A fourth group of children will be studied separately to compare different methods of measuring sub-clinical deficiency of vit A.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases malaria
- social sciences sociology demography mortality
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1300 Lisboa
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.