Objective
The adult pancreas consists mainly of exocrine acinar and duct cells, with interspersed endocrine islets. All these cells arise from embryonic protodifferentiated duct cells. In adult life, the exocrine cells retain phenotypic plasticity. In pancreatic pathology and regenerative conditions, acino-ductal metaplasia has been shown. A major problem in tackling the relationship between these cell types is the lack of stage-specific cell differentiation markers for study which - in turn - hampers the development of reliable genetic-based cell lineage-tracing studies.
This project aims at developing new insights into the acinar versus ductal phenotype on one hand, and the differences between embryonic duct cells, normal adult duct cells, and metaplastic exocrine cells on the other hand. The transcriptome of these cell types will be analyzed using laser capture microdissection and microarrays. In addition, we will explore the role of Notch signalling as a cell fate decision maker in exocrine cell phenotypic changes, during pancreatic pathology and endocrine cell neogenesis. Notch will be overexpressed in normal adult pancreas via virus-mediated gene delivery targeted to the acinar or duct cell population. Effects on the exocrine phenotype will be evaluated.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics RNA transcriptomes
- medical and health sciences basic medicine pathology
- natural sciences physical sciences optics laser physics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BARCELONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.