Objective
The proposed programme of research concerns the implementation of linear and two-directional strategies for the rapid total synthesis of the marine polyether natural product hemibrevetoxin B using novel ring-closing metathesis (RCM) methodology. Both of these approaches will employ catalytic RCM reactions of enol ethers, allylic ethers and alkynyl ethers that have been developed in the Clark Research Group in order to construct the cyclic ethers that are embedded in the fused tetracyclic structure of hemibrevetoxin B. A total synthesis of hemibrevetoxin B with a longest linear sequence of less than 30 steps from readily available starting materials should be achievable using the strategies outlined in the proposal. Hemibrevetoxin B is the smallest of the laddered polyether natural products but the strategies developed for the synthesis of this compound should be directly applicable to the synthesis of the larger bioactive members of this family of natural products such as the ciguatioxins and gambieric acids.
Fields of science (EuroSciVoc)
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
GLASGOW
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.