Objective
Ghrelin is a 28aamino acid peptide derived from a prepropeptide of 117 residues, named pre-proghrelin. Very recently it was identified a new ghrelin-associated peptide encoded by a 23aamino acid peptide, with a flanking conserved glycine residue at the C terminus named obestatin. Obestatin showed a high affinity for GPR39 and needs an amidation to be biologically active.
Regarding its physiological effects, obestatin is able to antagonize ghrelin effects on food intake, body weight and gastric emptying, but had no effect on growth hormone levels. Intraperitoneal and intracerebroventricular injection of obestatin suppressed food intake in a time- and dose-dependent manner. In contrast, treatment with the non-amidated obestatin was less effective. The fact that the same precursor leads to two different peptides with orexigenic and anorexigenic actions shows us that energy balance depends not only of the expression of different peptides but also the rate of transcription from the precursor to aSleana or aSfata gene is very important.
As it is typical when a new discovery appears, numerous unanswered questions arise and further studies will be necessary to find those answers. For instance, even obestatin decreased the food intake and body weight in rodents, serum leptin levels were not affected after treatment with obestatin, suggesting minimal modulation of body-fat content. Moreover, fasting did not change serum obestatin levels and circulating levels of obestatin are much lower than ghrelin, thus the relevance of endogenous obestatin remains unclear. Finally, from a pharmacological point of view, the most interesting will be to check if obestatin changes the food intake or the body weight in humans.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
SANTIAGO DE COMPOSTELA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.