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Dengue research Framework for Resisting Epidemics in Europe

Objective

"WHO estimates that one of the main consequences of global warming will be an increased burden of vector-borne diseases. Among these, dengue appears to be particularly problematic, with tens of millions of cases of dengue fever estimated to occur annually, including up to 500,000 cases of the life-threatening dengue hemorrhagic fever/dengue shock syndrome. In recent years, the global burden of dengue disease has been rising dramatically and this prolific increase has been connected to societal changes such as population growth, urbanization and the transport of infected hosts and vectors. In addition, rising temperatures and global climate change may lead to the expansion of the range of major mosquito vectors, extension of the transmission season in areas with currently circulating dengue virus and increase in the mosquito spp. vectorial capacity. Active surveillance to detect in-coming dengue virus (DENV) in regions at the limits of DENV circulation are an important initial step in the prevention of dengue epidemics in Europe. Asymptomatic infections likely play a crucial role in the initial invasion process and DENV transmission and, although hitherto ignored, must be addressed.
Using retrospective and prospective data from Asia, the main objectives of the program are (1) to identify key factors determining dengue transmission, outcome of infection and epidemics; (2) the development of novel diagnostic tools to detect asymptomatic infections. We will estimate the risk of DENV spreading to uninfected areas, especially in Southern Europe where susceptible vector exists. The major tools generated will be predictive models that enable specific interventions to reduce epidemic probability and diagnostic methods for surveillance. Inherent in this approach is the belief that improved surveillance and diagnosis of the asymptomatic dengue carriers will contribute to effective intervention, especially during early stages of pathogen invasion into a naïve region."

Call for proposal

FP7-HEALTH-2011-single-stage
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Coordinator

INSTITUT PASTEUR
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
France
Activity type
Research Organisations
EU contribution
€ 1 396 860,04
Administrative Contact
Sophie Ablott (Mrs.)

Participants (14)

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 429 791,80
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Scott Wheatley (Mr.)
BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN
Germany
EU contribution
€ 336 560
Address
Bernhard Nocht Strasse 74
20359 Hamburg
Activity type
Research Organisations
Administrative Contact
Michael Schreiber (Dr.)
MAHIDOL UNIVERSITY
Thailand
EU contribution
€ 574 280
Address
Ratchawithi Road 420/6
10400 Bangkok
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pornpimon Adams (Ms.)
INSTITUT PASTEUR DU CAMBODGE FOUNDATION
Cambodia
EU contribution
€ 821 504,20
Address
Boulevard Monivong 5
000 Phnom Penh
Activity type
Research Organisations
Administrative Contact
Paul Horwood (Dr.)
FUNDACIO INSTITUT CATALA DE CIENCIES DEL CLIMA
Spain
EU contribution
€ 399 304,50
Address
Carrer Doctor Trueta 203 3R Pis
08005 Barcelona
Activity type
Research Organisations
Administrative Contact
Carine Saüt (Ms.)
UNIVERSITE DE ROUEN NORMANDIE
France
EU contribution
€ 356 800
Address
Rue Thomas Becket 1 Mont Saint Aignan
76821 Mont Saint Aignan Cedex
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Philippe Moguérou (Dr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 236 168
Address
Rue Michel Ange 3
75794 Paris
Activity type
Other
Administrative Contact
Julie Zittel (Ms.)
FUNDACAO DA FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA FP
Portugal
EU contribution
€ 288 000
Address
Campo Grande Edificio C1 Piso 3
1749 016 Lisboa
Activity type
Research Organisations
Administrative Contact
Livia Moreira (Ms.)
IPATIMUP - INSTITUTO DE PATOLOGIA E IMUNOLOGIA MOLECULAR DA UNIVERSIDADE DO PORTO PCUP
Portugal
EU contribution
€ 267 600
Address
Rua Julio Amaral De Carvalho 45
4200 135 Porto
Activity type
Research Organisations
Administrative Contact
Ana Sofia Santos Silva (Dr.)
BIOCOMPUTING PLATFORMS LTD OY
Finland
EU contribution
€ 213 960
Address
Innopoli 3 Vaisalantie 6
02130 Espoo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Timo Kanninen (Mr.)
AMPTEC GMBH
Germany
EU contribution
€ 324 480
Address
Koenigstrasse 4A
22767 Hamburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Guido Krupp (Dr.)
RIOTECH PHARMACEUTICALS LTD
United Kingdom
EU contribution
€ 204 480
Address
Albert Street 6
CB4 3BE Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mark Thursz (Prof.)
INSTITUTO DE MEDICINA TROPICAL PEDRO KOURI
Cuba
EU contribution
€ 109 273,46
Address
Autopista Novia Mediodia Km 6 1/2
11300 La Habana
Activity type
Research Organisations
Administrative Contact
Maria Guadalupe Guzman (Prof.)
INSTITUT LOUIS MALARDE
French Polynesia
EU contribution
€ 40 000
Address
Rue Du 5 Mars 1797
98713 Papeete
Activity type
Research Organisations
Administrative Contact
Van-Mai Cao-Lormeau (Dr.)