Objective
"This project proposes to design and synthesise a series of novel fluorescent molecular rotors able to measure microviscosity of cellular domains based on the fluorescence lifetime. The fluorescence detection is an efficient and direct way to localise the molecules within cells whereas the measurement of the fluorescence lifetime provides a number of additional assets since the fluorescence decay is typically sensitive to the environment of the fluorophore. In molecular rotors the lifetime can be correlated with viscosity of their immediate environment. Besides, fluorescence lifetime is concentration independent and allows to account for the aggregation phenomenon, and other detrimental quenching processes, the data which is unavailable from the simple intensity measurements. As such, lifetime based detection of molecular rotor fluorescence will provide a quick and accurate measure of the microviscosity in individual cell domains, unavailable from other methods.
The new molecular rotors, with incorporated substituents to achieve extensive electronic conjugation, will have advantageous spectroscopic properties, such as high two-photon absorption cross sections and red-shifted absorption and emission wavelengths in the tissue therapeutic window, important both for diagnostic and therapy. These new superior dyes will be used for viscosity imaging in cells, with the emphasis on measuring the viscosity of hydrophobic membranes and on the monitoring of the viscosity changes during Photodynamic Therapy (PDT), a light activated cancer treatment of clinical importance.
This project has the ideal overlap of experience and expertise between the applicant and the host group. The results will be both of fundamental importance and practical significance, e.g. for the development of future imaging strategies in biological research. This fellowship will enable the applicant to learn new biology-related skills and as such will prove instrumental for her future academic career."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences optics microscopy fluorescence lifetime imaging
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SW7 2AZ London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.