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The Body-on-a-Chip (BoC)

Objective

High attrition and failures rates in pharmaceutical and biotechnological drug development require a paradigm change towards more physiological human cell-based assays at an early time point in the process. The central idea of this proposal is to develop a versatile and reconfigurable pharmaceutical screening technology platform that relies on organotypic three-dimensional spherical microtissues. This platform will accommodate different types of human microtissues (tumor, brain, liver, heart etc.) and feature microfluidic interconnection between these tissues, thus mimicking the physiological context and conditions in a human body. Dosage of components or candidate drugs to, e.g., liver tissue will lead to the generation of metabolic products in the respective tissue compartment. These products then can be routed via the microfluidics to, e.g., connective tissue to assess the efficacy of the candidate drug and related adverse toxicological effects on the target tissue and functionally related tissues. This way, functional connectivity in a real body can be mimicked at the desired level of complexity, and the effects of drugs can be comprehensively assessed.

Coordinator

INSPHERO AG

Address

Wagistrasse 27
8952 Schlieren

Switzerland

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

EU Contribution

€ 365 250

Administrative Contact

Jan Lichtenberg (Dr.)

Participants (4)

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KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

EU Contribution

€ 326 000

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Switzerland

EU Contribution

€ 326 000

FORSCHUNGSGESELLSCHAFT FUR ARBEITSPHYSIOLOGIE UND ARBEITSSCHUTZ E.V.

Germany

EU Contribution

€ 275 750

ASTRAZENECA UK LIMITED

United Kingdom

EU Contribution

€ 102 000

Project information

Grant agreement ID: 296257

Status

Closed project

  • Start date

    1 June 2012

  • End date

    31 May 2015

Funded under:

FP7-ICT

  • Overall budget:

    € 1 919 000

  • EU contribution

    € 1 395 000

Coordinated by:

INSPHERO AG

Switzerland