Project description High-Tech Research Intensive SMEs in FET research Show the project objective Hide the project objective High attrition and failures rates in pharmaceutical and biotechnological drug development require a paradigm change towards more physiological human cell-based assays at an early time point in the process. The central idea of this proposal is to develop a versatile and reconfigurable pharmaceutical screening technology platform that relies on organotypic three-dimensional spherical microtissues. This platform will accommodate different types of human microtissues (tumor, brain, liver, heart etc.) and feature microfluidic interconnection between these tissues, thus mimicking the physiological context and conditions in a human body. Dosage of components or candidate drugs to, e.g. liver tissue will lead to the generation of metabolic products in the respective tissue compartment. These products then can be routed via the microfluidics to, e.g. connective tissue to assess the efficacy of the candidate drug and related adverse toxicological effects on the target tissue and functionally related tissues. This way, functional connectivity in a real body can be mimicked at the desired level of complexity, and the effects of drugs can be comprehensively assessed. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidicsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs Programme(s) FP7-ICT - Specific Programme "Cooperation": Information and communication technologies Topic(s) ICT-2011.9.2 - High-Tech Research Intensive SMEs in FET research Call for proposal FP7-ICT-2011-C See other projects for this call Funding Scheme CP - Collaborative project (generic) Coordinator INSPHERO AG Address Wagistrasse 27 8952 Schlieren Switzerland See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jan Lichtenberg (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 326 000,00 Address Oude markt 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Administrative Contact Sofie Heroes (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland EU contribution € 326 000,00 Address Raemistrasse 101 8092 Zuerich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Andreas Hierlemann (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data FORSCHUNGSGESELLSCHAFT FUR ARBEITSPHYSIOLOGIE UND ARBEITSSCHUTZ EV Germany EU contribution € 275 750,00 Address Ardeystrasse 67 44139 Dortmund See on map Region Nordrhein-Westfalen Arnsberg Dortmund, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Jan Hengstler (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ASTRAZENECA UK LIMITED United Kingdom EU contribution € 102 000,00 Address 1 francis crick avenue cambridge biomedical campus CB2 0AA Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Eric Tang (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
