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The role of Chronic DNA damage in Ageing and Age-related pathology

Objective

Ageing is an inexorable homeostatic failure of largely unknown aetiology that leads to increased vulnerability to disease limiting the quality of life in the elderly and creating high costs to the society. Until recently, the daunting complexity of the ageing process, the conspicuous lack of tools to study it, and a dearth of experimentally tractable model systems have greatly hindered any hypothesis-driven reductionist approaches to understand the molecular basis of ageing. Whereas molecular and cellular damage is thought to be a cause of ageing and age-related pathologies, little is known about the molecular events that underlie ageing or determine longevity. A large number of progeroid syndromes that are characterized by an early onset of age-related pathology are linked to inborn defects in genome maintenance thus pointing towards damage in (nuclear) DNA as a major culprit of ageing and age-related pathology. DNA damage fuelled by intrinsic and
environmental sources of genotoxic insult and by errors of genome maintenance mechanisms invariably accumulates with advancing age. The outcome of DNA damage is diverse and generally adverse: DNA lesions may physically obstruct essential processes including DNA replication and transcription. In addition, DNA damage activates checkpoint responses that lead to a reduction in cell proliferation potential (cellular senescence) or to an increase in cell death. As a result, depending on the type and severity of DNA injuries and the cellular response to DNA damage, these cellular mechanisms impair organ maintenance and function during ageing. The CodAge ITN proposes an integrated approach in studying the role of Chronic DNA damage in Ageing and age-related pathology.

Call for proposal

FP7-PEOPLE-2012-ITN
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Coordinator

UNIVERSITAT ZU KOLN
Address
Albertus Magnus Platz
50931 Koln
Germany

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Heike Brucherseifer (Ms.)
EU contribution
€ 792 370,78

Participants (8)

IDRYMA TECHNOLOGIAS KAI EREVNAS
Greece
EU contribution
€ 910 022,52
Address
N Plastira Str 100
70013 Irakleio

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Activity type
Research Organisations
Administrative Contact
Zinovia Papatheodorou (Mrs.)
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
EU contribution
€ 570 113,28
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Aleona Blinova (Ms.)
IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS
Italy
EU contribution
€ 240 837,96
Address
Via Adamello 16
20139 Milano

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Activity type
Research Organisations
Administrative Contact
Carlo Raimondi Cominesi (Mr.)
LEIBNIZ-INSTITUT FUR ALTERNSFORSCHUNG - FRITZ-LIPMANN-INSTITUT EV (FLI) LEIBNIZ INSTITUTE ON AGING - FRITZ LIPMANN INSTITUTE EV (FLI)
Germany
EU contribution
€ 222 068,88
Address
Beutenbergstrasse 11
07745 Jena

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Activity type
Research Organisations
Administrative Contact
Wilfried Briest (Dr.)
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
EU contribution
€ 246 086,94
Address
Batiment Ce 3316 Station 1
1015 Lausanne

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Joachim Lingner (Dr.)
MOSAIQUES DIAGNOSTICS GMBH
Germany
EU contribution
€ 222 068,88
Address
Rotenburger Strasse 20
30659 Hannover

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Harald Mischak (Prof.)
BIOMEDCODE ELLAS ANONIMI ETERIA EPISTIMONIKIS KAI TEXNOLOGIKIS EREVNAS KAI EMBORIKIS EKMETALLEFSIS EPHARMOGON IATRIKIS
Greece
EU contribution
€ 222 068,88
Address
Alexander Fleming Street 34
16672 Vari

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Maria Denis (Dr.)
ATLAS BIOLABS GMBH
Germany
EU contribution
€ 222 068,88
Address
Kerpener Strasse 61-69
50937 Koln

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Karsten Heidtke (Dr.)