Objective In order to understand distributed biological networks and invent effective molecular therapies, we need to be able to image and control molecular processes across entire live organisms.Although an arsenal of genetically encoded fluorescent sensors and light-activated proteins has recently been developed to visualize and manipulate cellular activity, these methods all suffer from the poor penetration of light through biological tissue, which makes them rather invasive for practical in vivo use in animal models and prevents whole-organ coverage.To overcome these substantial limitations of optical methods, I thus propose a reverse engineering project to functionally dissect the molecular machinery for magnetic biomineralisation in eukaryotic cells and build a new bioengineering platform for genetically controlled bio-magnetic interfaces. To achieve this goal, we will use a combination of magnetic cell sorting and biophysical characterization, targeted analysis and -omics approaches as well as genetic tools. This scientific program will break the ground for non-invasive sensing and actuation of molecular processes via magnetic fields based on genetic control over the biosynthesis of magnetic biominerals. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensors Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-SG-LS9 - ERC Starting Grant - Applied life sciences and biotechnology Call for proposal ERC-2012-StG_20111109 See other projects for this call Funding Scheme ERC-SG - ERC Starting Grant Host institution KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN EU contribution € 649 598,00 Address ISMANINGER STRASSE 22 81675 Muenchen Germany See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Principal investigator Gil Gregor Westmeyer (Prof.) Administrative Contact Renate Rädlein (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Beneficiaries (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN Germany EU contribution € 649 598,00 Address ISMANINGER STRASSE 22 81675 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Principal investigator Gil Gregor Westmeyer (Prof.) Administrative Contact Renate Rädlein (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Germany EU contribution € 819 502,00 Address INGOLSTADTER LANDSTRASSE 1 85764 Neuherberg See on map Region Bayern Oberbayern München, Landkreis Activity type Research Organisations Administrative Contact Juergen Ertel (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
