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Digital radiation therapy patient

Objective

The past decade has seen a revolution in radiation therapy technology, offering exceptional flexibility in dose delivery. Image guidance during treatment ensures a reliable targeting of the dose to the tumor. This has created the possibility to irradiate the tumor with a high dose with minimal exposure of surrounding tissue. Thus an improvement in tumor control is no longer invariably associated with an increase in radiation-induced toxicity.Now, the capacity exists to create treatment plans that are tailored to the specific characteristics of the patient. Thus, the success of radiotherapy depends on proper personalized therapy planning and outcome prediction. However, an individualized representational model that informs on radiation therapy planning and outcome prediction is still lacking.There are several modeling approaches available that have the potential to fill this gap, among them empirical, but established radiobiological models and more sophisticated multi-scale models.DR THERAPATs aim is to create the Digital Radiation Therapy Patient, integrating the available knowledge on tumor imaging, image analysis and interpretation, radiobiological models and radiation therapy planning into a reusable, multi-scale digital representation. DR THERAPAT will enable 1) Broad access to dose painting 2) Individualized planning resulting in more effective and safer treatment 3) Accurate prediction of Tumor Control Probability and Normal Tissue Complication Probability, 4) improve outcome, 5) provide a platform demonstrating the integration of modeling into the clinical workflow, and 6) provide a platform for the validation of the models.A demonstrator of this platform will be made for prostate cancer. With a second demonstrator for cervical cancer, we will show that the model can be translated to other forms of cancer. DR THERAPAT will adapt and integrate today's available tools into a digital representation of the patients health status and clinical workflow.
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Coordinator

Philips GmbH

Address

Luebeckertordamm 5
20099 Hamburg

Germany

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

EU Contribution

€ 728 418

Administrative Contact

Patrick Keur (Mr.)

Participants (9)

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KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

EU Contribution

€ 618 920

PHILIPS TECHNOLOGIE GMBH

Germany

AARHUS UNIVERSITETSHOSPITAL

Denmark

EU Contribution

€ 70 170

AARHUS UNIVERSITET

Denmark

EU Contribution

€ 550 673

INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS

Greece

EU Contribution

€ 322 950

PHILIPS MEDICAL SYSTEMS NEDERLAND BV

Netherlands

EU Contribution

€ 105 528

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS

Netherlands

EU Contribution

€ 784 120

TECHNISCHE UNIVERSITEIT EINDHOVEN

Netherlands

EU Contribution

€ 321 221

STICHTING ANTONI VAN LEEUWENHOEK ZIEKENHUIS

Netherlands

Project information

Grant agreement ID: 600852

Status

Closed project

  • Start date

    1 February 2013

  • End date

    31 January 2016

Funded under:

FP7-ICT

  • Overall budget:

    € 5 001 091

  • EU contribution

    € 3 502 000

Coordinated by:

Philips GmbH

Germany