Objective
The present proposal aims to develop two novel classes of functional probes, which will enable the measurement of viscosity in cells. This important physiological parameter will be measured during normal cell function and during photodynamic therapy (PDT), a photoactivated cancer treatment of clinical importance. To achieve these objectives, we will characterise and use two types of tetrapyrrole macrocycles: porphycenes and porphyrazines as red/NIR emissive molecular rotors and PDT sensitizers and we will measure viscosity based on their fluorescence lifetime. The molecules will be used first in model systems such as vesicles, liposomes and gels and then in the complex environment of living cells. Protocols for the simultaneous detection of viscosity and other important physiological parameters such as pH will be developed. The novel methods will allow the quantification of viscosity in heterogeneous media, which is fundamental for understanding the complex dynamics of important biological, chemical and physical processes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences optics microscopy fluorescence lifetime imaging
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SW7 2AZ London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.