Objective "An important factor that influences therapy response and prognosis of cancer patients has been identified as intratumoral heterogeneity. Gastrointestinal cancers are known to be morphologically and molecularly very heterogeneous diseases. Thus, there is a strong need to identify clinically relevant tumor subpopulations and characterize their genetic and proteomic features. A novel technology which allows the untargeted and spatially resolved analysis of the molecular content of tissues while preserving the histology of the tissue sections is MALDI (matrix-assisted laser desorption/ionization) imaging mass spectrometry, in short MALDI imaging. It has been demonstrated that MALDI imaging constitutes a unique tool to discover tumor subpopulations based solely on the detected mass spectrometry profiles that are not distinguishable by conventional histopathological methods. The objectives of this project are (i) to identify clinical relevant tumor subpopulations by MALDI imaging in gastrointestinal cancers with regard to disease outcome and metastasis as clinical endpoints, and (ii) to characterize the molecular properties of these subpopulations on a genetic, proteomic, and metabolomic level. This could provide more knowledge about the biology of tumors and their molecular variance, and result in novel markers for therapy prediction or prognosis of patients, thus aiding the progress towards more personalized-medicine." Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesclinical medicineoncologynatural scienceschemical sciencesanalytical chemistrymass spectrometrynatural sciencesbiological scienceshistologynatural sciencesphysical sciencesopticslaser physics Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2012-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Call for proposal FP7-PEOPLE-2012-IEF See other projects for this call Funding Scheme MC-IEF - Intra-European Fellowships (IEF) Coordinator ACADEMISCH ZIEKENHUIS LEIDEN EU contribution € 175 974,60 Address ALBINUSDREEF 2 2333 ZA Leiden Netherlands See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Administrative Contact Linda Ouwerkerk (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
