Objetivo Nanomedicine offers capability to significantly change the course of treatment for life-threatening diseases. Many of the most significant current therapeutic targets, to be viable in practice, require the efficient crossing of at least one biological barrier. However, the efficient and controlled crossing of the undamaged barrier is difficult. The range of small molecules that can successfully do so (via diffusive or other non-specific processes) is limited in size and physiochemical properties, greatly restricting the therapeutic strategies that may be applied. In practice, after several decades of limited success, there is a broad consensus that new multi-disciplinary, multi-sectoral strategies are required. Key needs include detailed design and understanding of the bionano-interafce, re-assessment of in vitro models used to assess transport across barriers, and building regulatory considerations into the design phase of nanocarriers.The overarching premises of the PathChooser ITN are that (i) significant advances can only be made by a more detailed mechanistic understanding of key fundamental endocytotic, transcytotic, and other cellular processes, especially biological barrier crossing; (ii) elucidating the Mode of Action / mechanism of successful delivery systems (beyond current level) will ensure more rapid regulatory and general acceptance of such medicines. Paramount in this is the design and characterization of the in situ interface between the carrier system and the uptake and signalling machinery. (iii) inter-disciplinary knowledge from a range of scientific disciplines is required to launch a genuine attack on the therapeutic challenge. The PathChooser ITN program of research and training will equip the next generation of translational scientists with the tools to develop therapies for a range of currently intractable (e.g. hidden in the brain) and economically unviable diseases (e.g. orphan diseases affecting a limited population). Ámbito científico medical and health sciencesmedical biotechnologynanomedicine Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2013-ITN - Marie-Curie Action: "Initial Training Networks" Convocatoria de propuestas FP7-PEOPLE-2013-ITN Consulte otros proyectos de esta convocatoria Régimen de financiación MC-ITN - Networks for Initial Training (ITN) Coordinador UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Aportación de la UE € 788 281,78 Dirección BELFIELD 4 Dublin Irlanda Ver en el mapa Región Ireland Eastern and Midland Dublin Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Donal Doolan (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (8) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo SYDDANSK UNIVERSITET Dinamarca Aportación de la UE € 284 579,46 Dirección CAMPUSVEJ 55 5230 Odense M Ver en el mapa Región Danmark Syddanmark Fyn Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Jan Mollenhauer (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH Alemania Aportación de la UE € 222 068,88 Dirección INHOFFENSTRASSE 7 38124 Braunschweig Ver en el mapa Región Niedersachsen Braunschweig Braunschweig, Kreisfreie Stadt Tipo de actividad Research Organisations Contacto administrativo Michael Straetz (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos KING'S COLLEGE LONDON Reino Unido Aportación de la UE € 289 456,64 Dirección STRAND WC2R 2LS London Ver en el mapa Región London Inner London — West Westminster Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Paul Labbett (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos E.P.O.S. IASIS RESEARCH AND DEVELOPMENT LTD Chipre Aportación de la UE € 378 437,40 Dirección KOSTI PALAMA 34 ASPELIA DIAM 5 1096 Lefkosia Ver en el mapa Región Κύπρος Κύπρος Κύπρος Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Andreani Odysseos (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Alemania Aportación de la UE € 222 068,88 Dirección HOFGARTENSTRASSE 8 80539 Munchen Ver en el mapa Región Bayern Oberbayern München, Kreisfreie Stadt Tipo de actividad Research Organisations Contacto administrativo Birgit Knepper-Nicolai (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos UNIVERSITY OF BRISTOL Reino Unido Aportación de la UE € 285 056,64 Dirección BEACON HOUSE QUEENS ROAD BS8 1QU Bristol Ver en el mapa Región South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Elodie Mahieu-Wedande (Mrs.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos THE UNIVERSITY OF MANCHESTER Reino Unido Aportación de la UE € 285 056,64 Dirección OXFORD ROAD M13 9PL Manchester Ver en el mapa Región North West (England) Greater Manchester Manchester Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Claire Faichnie (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos AvantiCell Science Ltd Reino Unido Aportación de la UE € 281 607,70 Dirección GIBBSYARD BUILDING KA6 5HW Ayr Ver en el mapa Región Scotland Southern Scotland South Ayrshire Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Joanna Oliver (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos