Objective Aneuploidy, an abnormal number of chromosomes, is a hallmark of cancer cells, affecting the majority of all human tumours. Aneuploidy arises when errors occur during mitosis, as the duplicated chromosomes are distributed between the two new daughter cells. Paradoxically, aneuploidy appears to have detrimental consequences for the physiology of untransformed cells in vitro, inhibiting rather than stimulating proliferation. This suggests that cancer cells have acquired mutations that help them cope with aneuploidy. Although it is clear that aneuploidy can contribute to cancer, the molecular consequences of aneuploidy remain elusive, as does how aneuploidy contributes to malignant transformation. The scientific aim of this network is to determine and compare the molecular consequences of different levels of aneuploidy, both in vivo and in vitro. Our network will train 9 Early Stage Career and 2 Experienced researchers in the aneuploidy field. To this aim, we are combining the expertise of labs that study the causes of aneuploidy with labs that induce aneuploidy in model organisms and study its consequences and also with labs that focus on the development of therapeutics that selectively kill aneuploid cell progeny. Our network is comprised of 11 full participants in 4 member states and 1 associated country and one associated partner, and includes 3 commercial enterprises. Within this network, we will provide technical training through research projects, but also through workshops and dedicated courses organized by the participants of this network. A significant part of the training will be provided by the industrial partners. Participating investigators and trainees will meet at a yearly conference to exchange and discuss results. Trainees will thus become experts in the field of aneuploidy while rapidly building up a scientific network for themselves, putting them in an excellent position to become future leaders in this field. Fields of science natural sciencesbiological sciencesgeneticsmutationmedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicinephysiologynatural sciencesbiological sciencesgeneticschromosomes Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2013-ITN - Marie-Curie Action: "Initial Training Networks" Call for proposal FP7-PEOPLE-2013-ITN See other projects for this call Funding Scheme MC-ITN - Networks for Initial Training (ITN) Coordinator STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS EU contribution € 329 920,20 Address PLESMANLAAN 121 1066 CX Amsterdam Netherlands See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Administrative Contact Henri Van Luenen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (13) Sort alphabetically Sort by EU Contribution Expand all Collapse all ACADEMISCH ZIEKENHUIS GRONINGEN Netherlands EU contribution € 376 758,36 Address HANZEPLEIN 1 9713 GZ Groningen See on map Region Noord-Nederland Groningen Overig Groningen Activity type Higher or Secondary Education Establishments Administrative Contact Floris Foijer (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAIR MEDISCH CENTRUM UTRECHT Participation ended Netherlands EU contribution € 91 033,31 Address HEIDELBERGLAAN 100 3584 CX Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Administrative Contact Geert Kops (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF MANCHESTER United Kingdom EU contribution € 296 056,64 Address OXFORD ROAD M13 9PL Manchester See on map Region North West (England) Greater Manchester Manchester Activity type Higher or Secondary Education Establishments Administrative Contact Claire Faichnie (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF EDINBURGH United Kingdom EU contribution € 296 056,64 Address OLD COLLEGE, SOUTH BRIDGE EH8 9YL Edinburgh See on map Region Scotland Eastern Scotland Edinburgh Activity type Higher or Secondary Education Establishments Administrative Contact Angela Noble (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAT BASEL Switzerland EU contribution € 272 515,76 Address PETERSPLATZ 1 4051 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Erich Nigg (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Germany EU contribution € 233 068,88 Address HOFGARTENSTRASSE 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Ulrike Jendis (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EUROPEAN MOLECULAR BIOLOGY LABORATORY Participation ended Germany EU contribution € 67 185,80 Address Meyerhofstrasse 1 69117 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Administrative Contact Sotillo Rocio (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CANCER RESEARCH UK LBG United Kingdom EU contribution € 53 009,44 Address 2 Redman Place E20 1JQ LONDON See on map Region London Inner London — West Camden and City of London Activity type Research Organisations Administrative Contact Holly Elphinstone (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NETHERLANDS TRANSLATIONAL RESEARCHCENTER BV Netherlands EU contribution € 219 979,10 Address KLOOSTERSTRAAT 9 5349 AB OSS See on map Region Zuid-Nederland Noord-Brabant Noordoost-Noord-Brabant Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Guido Zaman (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MILTENYI BIOTEC GMBH Germany EU contribution € 205 554,80 Address FRIEDRICH EBERT STRASSE 68 51429 Bergish Gladbach See on map Region Nordrhein-Westfalen Köln Rheinisch-Bergischer Kreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Olaf Thorsten Hardt (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE FRANCIS CRICK INSTITUTE LIMITED United Kingdom EU contribution € 240 934,10 Address 1 MIDLAND ROAD NW1 1AT London See on map Region London Inner London — West Camden and City of London Activity type Research Organisations Administrative Contact Justin Wilson (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW Netherlands EU contribution € 154 078,15 Address KLOVENIERSBURGWAL 29 HET TRIPPENHUIS 1011 JV AMSTERDAM See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Administrative Contact Don Van Velzen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG Germany EU contribution € 181 638,82 Address IM NEUENHEIMER FELD 280 69120 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Administrative Contact Josef Puchta (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
