Objective
The present study aims to elucidate how bidirectional signaling systems regulate synapse formation and activity, in vivo. In particular, I will address how repulsive actions of Eph/ephrin signaling during axon pathfinding are overcome and turned into adhesive actions, required for synapse formation and functioning. Therefore, I will study the effects of either stimulation or inhibition of Eph receptor clustering in two different in vivo models and, in an inducible way. Live-imaging of Eph receptors in the zebrafish retinotectal system will enable study of their localization and trafficking, as well as the effect of clustering modulations on the ensuing cellular response. Four different aspects of retinotectal system formation will be evaluated, including topographic mapping and arborization of retinoganglion cells as well as synapse formation and stability. Furthermore, an EphA4 knock-in mouse will be generated to study the effect of clustering during synaptic transmission and on synapse stability in the hippocampus. Therefore morphological, electrophysiological and functional approaches will be used. A final part of this project aims to find downstream signaling effectors that are specifically recruited or activated by lower- or higher order Eph receptor clusters.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine physiology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.