Objetivo There is an undoubted need of new small molecule libraries with high levels of scaffold diversity in order to address challenging ‘undruggable’ biological targets which have proven largely intractable to small molecule modulation using traditional compound libraries. The efficient de novo generation of such collections presents a formidable challenge to the synthetic chemist; over the course of the last decade diversity-oriented synthesis has established itself as a powerful tool in this regard. The research outlined in this Marie Curie Fellowship proposal is advancing the impact that synthetic organic chemistry will have on the drug discovery process employing diversity-oriented synthesis. We proposed the preparation of a novel and diverse library of conformationally constrained peptidomimetics containing quaternary stereocenters derived from B/C/P approach with increased biological relevance. In order to provide a visually accessible representation of the abstract concepts of chemical space and the molecular diversity of our new chemical libraries a computational assessment will be developed. As a final step, the small-molecules obtained will be screened to identify new molecular targets against cancer and infectious diseases. This is a multidisciplinary project that involves a highly valuable education for the candidate in new scientific aspects related to her research field. Ámbito científico medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural scienceschemical sciencesorganic chemistrymedical and health scienceshealth sciencesinfectious diseasesmedical and health sciencesclinical medicineoncology Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2013-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Convocatoria de propuestas FP7-PEOPLE-2013-IEF Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IEF - Intra-European Fellowships (IEF) Coordinador THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Aportación de la UE € 231 283,20 Dirección TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge Reino Unido Ver en el mapa Región East of England East Anglia Cambridgeshire CC Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Renata Schaeffer (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
