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Exploring the combined role of genetic and non-genetic factors for developing Age-Related Macular Degeneration: A systems level analysis of disease subgroups, risk factors, and pathways

Exploring the combined role of genetic and non-genetic factors for developing Age-Related Macular Degeneration: A systems level analysis of disease subgroups, risk factors, and pathways

Objective

Age-related macular degeneration (AMD) is the world’s most important age-related blinding disorder. The current proposal utilises epidemiological data describing clinical phenotype, molecular genetics, lifestyle, nutrition, and in-depth retinal imaging derived from existing longitudinal European epidemiological cohorts and biobanks to provide three major insights needed for long-lasting prevention and therapy for AMD: (a) the development of robust algorithms utilising genetic and non-genetic risk factors to identify personalised risks of developing advanced wet and dry AMD; (b) the identification of novel biomarkers for further stratification of disease risks.
New insights from (a)+(b) will be used to elaborate preventive medical recommendations for highrisk subgroups of AMD patients; and (c) the identification of molecular drivers/biological pathways relevant for onset and progression of advanced AMD that will be used to identify and validate new therapeutic targets.

Key deliverables are:
1. Determination of AMD frequency in Europe, and assessment of AMD risk for phenotypical, genetic, environmental, and biochemical risk factors and their interaction. (WP1-3)
2. Development of a web-based prediction model for personalised risk assessment of AMD based on integration of risk profiles derived from retinal imaging, molecular genetics, assessment of lifestyle, and biochemical testing. (WP4)
3. Modelling and functional characterisation of pathophysiological pathways identified from integrated analysis of current knowledge and the above risk profiles. (WP5)
4. Experimental testing and interpretation of pathophysiological consequences of risks at the molecular level. (WP6)
5. An extension and refinement of the prediction model (WP4) based on work in WP5 and WP6 to generate clinical guidelines for the medical management of high-risk subgroups of patients with AMD. (WP7)
6. Promotion and dissemination of newly gained knowledge towards AMD prevention and therapy development
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Coordinator

EBERHARD KARLS UNIVERSITAET TUEBINGEN

Address

Geschwister-Scholl-Platz
72074 Tuebingen

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 360 875

Participants (13)

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ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

EU Contribution

€ 962 250

FUNDACIO CENTRE DE REGULACIO GENOMICA

Spain

EU Contribution

€ 360 000

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

EU Contribution

€ 539 375

UNIVERSITE DE BORDEAUX

France

EU Contribution

€ 416 875

UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 501 992,11

FUNDACION BARCELONA MACULA FOUNDATION RESEARCH FOR VISION

Spain

EU Contribution

€ 320 531

PRO RETINA DEUTSCHLAND

Germany

EU Contribution

€ 106 250

AYOXXA BIOSYSTEMS GMBH

Germany

EU Contribution

€ 608 500

F. HOFFMANN-LA ROCHE AG

Switzerland

MOORFIELDS EYE HOSPITAL NHS FOUNDATION TRUST

United Kingdom

EU Contribution

€ 124,38

FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD

Spain

EU Contribution

€ 198 607,50

THE QUEEN'S UNIVERSITY OF BELFAST

United Kingdom

EU Contribution

€ 592 116,01

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

Ireland

EU Contribution

€ 5 000

Project information

Grant agreement ID: 634479

Status

Closed project

  • Start date

    1 May 2015

  • End date

    30 April 2019

Funded under:

H2020-EU.3.1.1.

  • Overall budget:

    € 6 069 996,25

  • EU contribution

    € 5 972 496

Coordinated by:

EBERHARD KARLS UNIVERSITAET TUEBINGEN

Germany