Exploring the combined role of genetic and non-genetic factors for developing Age-Related Macular Degeneration: A systems level analysis of disease subgroups, risk factors, and pathways

Project Information

EYE-RISK

Grant agreement ID: 634479

DOI 10.3030/634479

Project closed

EC signature date 7 April 2015

Start date 1 May 2015

End date 30 April 2019

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 6 069 996,25

EU contribution € 5 972 496,00

Coordinated by

EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany

Deliverables

Websites, patent fillings, videos etc. (1)

EYE-RISK website

Establishment and launch of the EYE-RISK website; creation of a website with two levels of accessibility, one for the public and one restricted to project members; regular updates after launch of the website.

Documents, reports (1)

Dissemination

EYE-RISK leaflets or leporellos developed, designed and sent to beneficiaries for further distribution/dissemination.

Other (1)

Workshops

EYE-RISK workshops organised.

Publications

Peer reviewed articles (19)

Geographic distribution of rare variants associated with age-related macular degeneration

Author(s): Geerlings, Maartje J.; Kersten, Eveline; Groenewoud, Joannes M.M.; Fritsche, Lars G.; Hoyng, Carel B.; de Jong, Eiko K.; den Hollander, Anneke I.
Published in: Molecular Vision, Issue 24, 2018, Page(s) 75-82, ISSN 1090-0535
Publisher: Molecular Vision

A new perspective on lipid research in age-related macular degeneration

Author(s): Elisabeth M. van Leeuwen, Eszter Emri, Benedicte M.J. Merle, Johanna M. Colijn, Eveline Kersten, Audrey Cougnard-Gregoire, Sascha Dammeier, Magda Meester-Smoor, Frances M. Pool, Eiko K. de Jong, Cécile Delcourt, Eduardo Rodrigez-Bocanegra, Marc Biarnés, Philip J. Luthert, Marius Ueffing, Caroline C.W. Klaver, Everson Nogoceke, Anneke I. den Hollander, Imre Lengyel
Published in: Progress in Retinal and Eye Research, 2018, ISSN 1350-9462
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.preteyeres.2018.04.006

Whole-Exome Sequencing in Age-Related Macular Degeneration Identifies Rare Variants in COL8A1 , a Component of Bruch’s Membrane

Author(s): Jordi Corominas, Johanna M. Colijn, Maartje J. Geerlings, Marc Pauper, Bjorn Bakker, Najaf Amin, Laura Lores Motta, Eveline Kersten, Alejandro Garanto, Joost A.M. Verlouw, Jeroen G.J. van Rooij, Robert Kraaij, Paulus T.V.M. de Jong, Albert Hofman, Johannes R. Vingerling, Tina Schick, Sascha Fauser, Eiko K. de Jong, Cornelia M. van Duijn, Carel B. Hoyng, Caroline C.W. Klaver, Anneke I. den Hollande
Published in: Ophthalmology, 2018, ISSN 0161-6420
Publisher: Elsevier BV
DOI: 10.1016/j.ophtha.2018.03.040

Phenotype Characteristics of Patients With Age-Related Macular Degeneration Carrying a Rare Variant in the Complement Factor H Gene

Author(s): Eveline Kersten, Maartje J. Geerlings, Anneke I. den Hollander, Eiko K. de Jong, Sascha Fauser, Tunde Peto, Carel B. Hoyng
Published in: JAMA Ophthalmology, Issue 135/10, 2017, Page(s) 1037, ISSN 2168-6165
Publisher: American Medical Association
DOI: 10.1001/jamaophthalmol.2017.3195

Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration

Author(s): Swati Arya, Eszter Emri, Silvia A. Synowsky, Sally L. Shirran, Neda Barzegar-Befroei, Tunde Peto, Catherine H. Botting, Imre Lengyel, Alan J. Stewart
Published in: Experimental Eye Research, Issue 172, 2018, Page(s) 21-29, ISSN 0014-4835
Publisher: Academic Press
DOI: 10.1016/j.exer.2018.03.023

The effects of zinc supplementation on primary human retinal pigment epithelium

Author(s): Po-Jung Pao, Eszter Emri, Safiya Bishar Abdirahman, Talha Soorma, Hui-Hui Zeng, Stefanie M. Hauck, Richard B. Thompson, Imre Lengyel
Published in: Journal of Trace Elements in Medicine and Biology, 2018, ISSN 0946-672X
Publisher: Elsevier BV
DOI: 10.1016/j.jtemb.2018.02.028

The unconventional secretion of ARMS2

Author(s): Elod Kortvely, Stefanie M. Hauck, Jennifer Behler, Nurulain Ho, Marius Ueffing
Published in: Human Molecular Genetics, 2016, Page(s) ddw162, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddw162

Opportunities and Challenges of Whole-Cell and -Tissue Simulations of the Outer Retina in Health and Disease

Author(s): Philip J. Luthert, Luis Serrano, Christina Kiel
Published in: Annual Review of Biomedical Data Science, Issue 1/1, 2018, Page(s) 131-152, ISSN 2574-3414
Publisher: Annual Reviews
DOI: 10.1146/annurev-biodatasci-080917-013356

Mediterranean Diet and Incidence of Advanced Age-Related Macular Degeneration

Author(s): Bénédicte M.J. Merle, Johanna M. Colijn, Audrey Cougnard-Grégoire, Alexandra P.M. de Koning-Backus, Marie-Noëlle Delyfer, Jessica C. Kiefte-de Jong, Magda Meester-Smoor, Catherine Féart, Timo Verzijden, Cécilia Samieri, Oscar H. Franco, Jean-François Korobelnik, Caroline C.W. Klaver, Cécile Delcourt, Soufiane Ajana, Blanca Arango-Gonzalez, Angela Armento, Verena Arndt, Vaibhav Bhatia, Shom
Published in: Ophthalmology, Issue 126/3, 2019, Page(s) 381-390, ISSN 0161-6420
Publisher: Elsevier BV
DOI: 10.1016/j.ophtha.2018.08.006

Metabolomics in serum of patients with non-advanced age-related macular degeneration reveals aberrations in the glutamine pathway

Author(s): Eveline Kersten, Sascha Dammeier, Soufiane Ajana, Joannes M. M. Groenewoud, Marius Codrea, Franziska Klose, Yara T. Lechanteur, Sascha Fauser, Marius Ueffing, Cécile Delcourt, Carel B. Hoyng, Eiko K. de Jong, Anneke I. den Hollander
Published in: PLOS ONE, Issue 14/6, 2019, Page(s) e0218457, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0218457

Genetic risk score has added value over initial clinical grading stage in predicting disease progression in age-related macular degeneration

Author(s): Thomas J. Heesterbeek, Eiko K. de Jong, Ilhan E. Acar, Joannes M. M. Groenewoud, Bart Liefers, Clara I. Sánchez, Tunde Peto, Carel B. Hoyng, Daniel Pauleikhoff, Hans W. Hense, Anneke I. den Hollander
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-43144-3

Genetic screening for macular dystrophies in patients clinically diagnosed with dry age‐related macular degeneration

Author(s): Eveline Kersten, Maartje J. Geerlings, Marc Pauper, Jordi Corominas, Bjorn Bakker, Lebriz Altay, Sascha Fauser, Eiko K. de Jong, Carel B. Hoyng, Anneke I. den Hollander
Published in: Clinical Genetics, Issue 94/6, 2018, Page(s) 569-574, ISSN 0009-9163
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/cge.13447

The Rate of Progression of Geographic Atrophy Decreases With Increasing Baseline Lesion Size Even After the Square Root Transformation

Author(s): Jordi Monés, Marc Biarnés
Published in: Translational Vision Science & Technology, Issue 7/6, 2018, Page(s) 40, ISSN 2164-2591
Publisher: Association for Research in Vision and Ophthalmology Inc.
DOI: 10.1167/tvst.7.6.40

Drusen Ooze: A Novel Hypothesis in Geographic Atrophy

Author(s): Jordi Monés, Míriam Garcia, Marc Biarnés, Aparna Lakkaraju, Lucia Ferraro
Published in: Ophthalmology Retina, 2017, ISSN 2468-6530
Publisher: Elsevier
DOI: 10.1016/j.oret.2017.02.006

Subretinal Pigment Epithelial Deposition of Drusen Components Including Hydroxyapatite in a Primary Cell Culture Model

Author(s): Matthew G. Pilgrim, Imre Lengyel, Antonio Lanzirotti, Matt Newville, Sarah Fearn, Eszter Emri, Jonathan C. Knowles, Jeffrey D. Messinger, Russell W. Read, Clyde Guidry, Christine A. Curcio
Published in: Investigative Opthalmology & Visual Science, Issue 58/2, 2017, Page(s) 708, ISSN 1552-5783
Publisher: Cadmus
DOI: 10.1167/iovs.16-21060

Simple and complex retinal dystrophies are associated with profoundly different disease networks

Author(s): Christina Kiel, Claire Lastrucci, Philip J. Luthert, Luis Serrano
Published in: Scientific Reports, Issue 7, 2017, Page(s) 41835, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep41835

Systemic and ocular fluid compounds as potential biomarkers in age-related macular degeneration

Author(s): Eveline Kersten, Constantin C. Paun, Rosa L. Schellevis, Carel. B. Hoyng, Cécile Delcourt, Imre Lengyel, Tunde Peto, Marius Ueffing, Caroline C.W. Klaver, Sascha Dammeier, Anneke I. den Hollander, Eiko K. de Jong
Published in: Survey of Ophthalmology, 2017, ISSN 0039-6257
Publisher: Elsevier BV
DOI: 10.1016/j.survophthal.2017.05.003

Prevalence of Age-Related Macular Degeneration in Europe

Author(s): Johanna M. Colijn, Gabriëlle H.S. Buitendijk, Elena Prokofyeva, Dalila Alves, Maria L. Cachulo, Anthony P. Khawaja, Audrey Cougnard-Gregoire, Bénédicte M.J. Merle, Christina Korb, Maja G. Erke, Alain Bron, Eleftherios Anastasopoulos, Magda A. Meester-Smoor, Tatiana Segato, Stefano Piermarocchi, Paulus T.V.M. de Jong, Johannes R. Vingerling, Fotis Topouzis, Catherine Creuzot-Garcher, Geir Bertel
Published in: Ophthalmology, 2017, ISSN 0161-6420
Publisher: Elsevier BV
DOI: 10.1016/j.ophtha.2017.05.035

Geographic atrophy phenotype identification by cluster analysis

Author(s): Jordi Monés, Marc Biarnés
Published in: British Journal of Ophthalmology, 2017, Page(s) bjophthalmol-2017-310268, ISSN 0007-1161
Publisher: BMJ Publishing Group
DOI: 10.1136/bjophthalmol-2017-310268