Metabolic flexibility: breaking down food effectively to prolong life

Project Information

MetaFlex

Grant agreement ID: 638290

DOI 10.3030/638290

Project closed

EC signature date 17 March 2015

Start date 1 April 2015

End date 31 March 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 499 446,25

EU contribution € 1 499 446,25

Coordinated by

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands

Publications

Peer reviewed articles (16)

A sensitive mass spectrometry platform identifies metabolic changes of life history traits in C. elegans

Author(s): Arwen W. Gao, Iliana A. Chatzispyrou, Rashmi Kamble, Yasmine J. Liu, Katharina Herzog, Reuben L. Smith, Henk van Lenthe, Martin A. T. Vervaart, Arno van Cruchten, Angela C. Luyf, Antoine van Kampen, Mia L. Pras-Raves, Frédéric M. Vaz, Riekelt H. Houtkooper
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-02539-w

Mitochondrial quality control pathways as determinants of metabolic health

Author(s): Ntsiki M. Held, Riekelt H. Houtkooper
Published in: BioEssays, Issue 37/8, 2015, Page(s) 867-876, ISSN 0265-9247
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/bies.201500013

Forward and reverse genetics approaches to uncover metabolic aging pathways in Caenorhabditis elegans

Author(s): Arwen W. Gao, Jelmi uit de Bos, Mark G. Sterken, Jan E. Kammenga, Reuben L. Smith, Riekelt H. Houtkooper
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, ISSN 0925-4439
Publisher: Elsevier BV
DOI: 10.1016/j.bbadis.2017.09.006

Tetracycline Antibiotics Impair Mitochondrial Function and Its Experimental Use Confounds Research

Author(s): I. A. Chatzispyrou, N. M. Held, L. Mouchiroud, J. Auwerx, R. H. Houtkooper
Published in: Cancer Research, Issue 75/21, 2015, Page(s) 4446-4449, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-15-1626

Antibiotic use and abuse: A threat to mitochondria and chloroplasts with impact on research, health, and environment

Author(s): Xu Wang, Dongryeol Ryu, Riekelt H. Houtkooper, Johan Auwerx
Published in: BioEssays, Issue 37/10, 2015, Page(s) 1045-1053, ISSN 0265-9247
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/bies.201500071

A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans

Author(s): Mandy Koopman, Helen Michels, Beverley M Dancy, Rashmi Kamble, Laurent Mouchiroud, Johan Auwerx, Ellen A A Nollen, Riekelt H Houtkooper
Published in: Nature Protocols, Issue 11/10, 2016, Page(s) 1798-1816, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/nprot.2016.106

Sirtuin activation as a therapeutic approach against inborn errors of metabolism

Author(s): Jeannette C. Bleeker, Riekelt H. Houtkooper
Published in: Journal of Inherited Metabolic Disease, Issue 39/4, 2016, Page(s) 565-572, ISSN 0141-8955
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10545-016-9939-8

From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs

Author(s): Rebecca L McIntyre, Eileen G Daniels, Marte Molenaars, Riekelt H Houtkooper, Georges E Janssens
Published in: EMBO Molecular Medicine, Issue 11/9, 2019, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201809854

Natural genetic variation in C. elegans identified genomic loci controlling metabolite levels

Author(s): Arwen W. Gao, Mark G. Sterken, Jelmi uit de Bos, Jelle van Creij, Rashmi Kamble, Basten L. Snoek, Jan E. Kammenga, Riekelt H. Houtkooper
Published in: Genome Research, Issue 28/9, 2018, Page(s) 1296-1308, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.232322.117

Mitochondrial ubiquinone–mediated longevity is marked by reduced cytoplasmic mRNA translation

Author(s): Marte Molenaars, Georges E Janssens, Toon Santermans, Marco Lezzerini, Rob Jelier, Alyson W MacInnes, Riekelt H Houtkooper
Published in: Life Science Alliance, Issue 1/5, 2018, Page(s) e201800082, ISSN 2575-1077
Publisher: EMBO Press, Rockefeller University Press, and Cold Spring Harbor Laboratory Press
DOI: 10.26508/lsa.201800082

Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion

Author(s): Yasmine J. Liu, Georges E. Janssens, Rebecca L. McIntyre, Marte Molenaars, Rashmi Kamble, Arwen W. Gao, Aldo Jongejan, Michel van Weeghel, Alyson W. MacInnes, Riekelt H. Houtkooper
Published in: PLOS Genetics, Issue 15/3, 2019, Page(s) e1007633, ISSN 1553-7404
Publisher: Public Library of Science
DOI: 10.1371/journal.pgen.1007633

Pyruvate dehydrogenase complex plays a central role in brown adipocyte energy expenditure and fuel utilization during short-term beta-adrenergic activation

Author(s): Ntsiki M. Held, Eline N. Kuipers, Michel van Weeghel, Jan Bert van Klinken, Simone W. Denis, Marc Lombès, Ronald J. Wanders, Frédéric M. Vaz, Patrick C. N. Rensen, Arthur J. Verhoeven, Mariëtte R. Boon, Riekelt H. Houtkooper
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-27875-3

A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways

Author(s): Marte Molenaars, Georges E. Janssens, Evan G. Williams, Aldo Jongejan, Jiayi Lan, Sylvie Rabot, Fatima Joly, Perry D. Moerland, Bauke V. Schomakers, Marco Lezzerini, Yasmine J. Liu, Mark A. McCormick, Brian K. Kennedy, Michel van Weeghel, Antoine H.C. van Kampen, Ruedi Aebersold, Alyson W. MacInnes, Riekelt H. Houtkooper
Published in: Cell Metabolism, Issue 31/3, 2020, Page(s) 549-563.e7, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2020.01.011

Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30

Author(s): Yasmine J. Liu, Rebecca L. McIntyre, Georges E. Janssens, Evan G. Williams, Jiayi Lan, Michel van Weeghel, Bauke Schomakers, Henk van der Veen, Nicole N. van der Wel, Pallas Yao, William B. Mair, Ruedi Aebersold, Alyson W. MacInnes, Riekelt H. Houtkooper
Published in: Journal of Cell Biology, Issue 219/6, 2020, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201907067

Mitochondrial cross-compartmental signalling to maintain proteostasis and longevity

Author(s): Marte Molenaars, Eileen G. Daniels, Amber Meurs, Georges E. Janssens, Riekelt H. Houtkooper
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, Issue 375/1801, 2020, Page(s) 20190414, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2019.0414

Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease

Author(s): Yasmine J. Liu, Rebecca L. McIntyre, Georges E. Janssens, Riekelt H. Houtkooper
Published in: Mechanisms of Ageing and Development, Issue 186, 2020, Page(s) 111212, ISSN 0047-6374
Publisher: Elsevier BV
DOI: 10.1016/j.mad.2020.111212