Objective
This project aims at changing the impact of optimal control methodology on solid state nuclear magnetic resonance (NMR). This way, routine structure determination of biological solids like amyloid fibrils and membrane proteins will be facilitated. Multi-dimensional experiments of these samples often suffer from low resolution and sensitivity. Optimal control theory provides efficient means for automated design of pulse experiments with improved efficiency, lower deposited radiofrequency power, and robustness with respect to experimental imperfections. The methodology has already been successfully applied to liquid state as well as solid state NMR. However, and especially for solids, the optimized pulse sequences are not used within the NMR community, probably due to barriers imposed by individual RF hardware characteristics of the employed probes and consoles. In order to change this we propose, in cooperation with the market leading manufacturer of NMR spectrometers, to study the interplay of the hardware with numerically predicted “optimal” experiments, including relaxation and reformulation of the optimization problem in a new theoretical framework. Such comprehensive optimizations should provide us with easy-to-use building blocks of multidimensional solid state NMR experiments with superior performance, boosting thus the sensitivity and the accessibility of structural information from the acquired spectra. To promote dissemination of the developed protocols a workshop on implementation of optimal control methods in magnetic resonance will be organized. The potential impact of the project is enormous, revolutionizing hardware development with new quality measures that combine its properties with fundamental laws of spin dynamics.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology electrical engineering, electronic engineering, information engineering information engineering telecommunications radio technology radio frequency
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences electromagnetism and electronics spintronics
- natural sciences physical sciences optics spectroscopy absorption spectroscopy
- natural sciences biological sciences molecular biology structural biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80333 Muenchen
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.