Objetivo All metazoans harbour considerable numbers of commensal microorganisms in the gut, named microbiota, that contribute to many aspects of normal host physiology. Scientific research has provided invaluable contributions to our understanding of the relationship between host and its microbiota; however, the molecular mechanisms through which the microbiota exerts its beneficial influence are still largely undefined. The meta’omics revolution is promoting an explosion of interest in how the gut bacterial community impacts physiology and propensity to disease. In addition, gnotobiotic model organisms provide unique opportunities to study host-microbiota interplay with a level of experimental control that is not achievable in human studies. The coupling of those two approaches should allow to pinpoint key mechanisms underlying this mutually beneficial relationship. This research proposal aims to use those approaches to understand the bacterial genetic pathways mediating host benefits. To this end, we will apply in vivo experimental evolution to mutualistic bacteria, using gnotobiotic animal models. The work will investigate the association between the host model Drosophila melanogaster and one of its most abundant commensal bacteria, Lactobacillus plantarum, which was demonstrated to be beneficial to its host physiology by promoting juvenile growth and maturation. Ámbito científico natural sciencesbiological sciencesmicrobiologybacteriologymedical and health scienceshealth sciencesnutritionmedical and health sciencesbasic medicinepathologymedical and health sciencesbasic medicinephysiologymedical and health sciencesclinical medicineembryology Programa(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Tema(s) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Convocatoria de propuestas H2020-MSCA-IF-2014 Consulte otros proyectos de esta convocatoria Régimen de financiación MSCA-IF-EF-ST - Standard EF Coordinador CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Aportación neta de la UEn € 173 076,00 Dirección RUE MICHEL ANGE 3 75794 Paris Francia Ver en el mapa Región Ile-de-France Ile-de-France Paris Tipo de actividad Research Organisations Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 173 076,00
