Objective Neurological disorders, such as multiple sclerosis (MS), that involves degeneration of the myelin sheath exact a social and economic toll on the EU estimated at 14.6 billion Euros per year. Consequently therapies capable of regenerating damaged myelin are an important clinical goal. The aim of this fellowship is to develop new strategies for the replacement of myelin through the use of embryonic stem (ES) cells. We propose to achieve this aim by identifying novel signalling molecules capable of enhancing the generation of myelin-forming oligodendrocytes from ES cells. Membrane depolarisation enhances myelination during postnatal development, and can promote the differentiation of ES-OL cells. However, the impact of depolarisation on the generation of oligodendrocytes from ES cells (ES-OL) is unknown, as are the signalling molecules driving depolarisation-induced ES cell differentiation. Filling these gaps has the potential to deliver new methods for increasing the supply of pro-myelinating ES-OL capable of regenerating damaged myelin. This fellowship will unite supervisor Dr Fulton’s expertise in oligodendrocyte biology and optogenetics with Dr Otsu’s knowledge and skills in novel methods for the efficient production of ES-OL. In addition, partner organisations from the commercial and clinical sectors will add additional expertise that will enhance the project’s research capacity, and ensure success in its goal of developing novel pathways towards myelin regeneration. Fields of science natural sciencesbiological sciencesneurobiologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesphysical sciencesopticsmicroscopymedical and health sciencesbasic medicineneurologymultiple sclerosismedical and health sciencesmedical biotechnologycells technologiesstem cells Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Call for proposal H2020-MSCA-IF-2014 See other projects for this call Funding Scheme MSCA-IF-EF-ST - Standard EF Coordinator THE UNIVERSITY OF BIRMINGHAM Net EU contribution € 195 454,80 Address Edgbaston B15 2TT Birmingham United Kingdom See on map Region West Midlands (England) West Midlands Birmingham Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 195 454,80