Objectif Abiotic stresses, such as drought or salt stress, affect plant growth and threaten the capacity to feed a growing world population. Understanding and altering how plants deal with stress will be critical for society’s adaptation to a changed climate. I propose a novel systems-biology based approach to identify biotechnological targets based on comparison of interaction and signalling networks of evolutionary related species that show differential abiotic stress tolerance. Similar to most crops, Arabidopsis thaliana is an abiotic-stress sensitive glycophyte whereas several close relatives are stress tolerant. This constitutes an opportunity to understand how plant stress-signalling networks are modified by evolutionary processes to adapt to novel environmental conditions.Biological processes are mediated by physically and functionally interacting proteins. Especially stress response networks are rewired when plants adapt to new environmental conditions. I aim to experimentally map the abiotic stress networks of four closely related brassicaceae: A. thaliana, A. lyrata, A. halleri and E. salsugineum. Novel conceptual advances in interactome mapping and a state-of-the art interactome mapping pipeline will be exploited to ensure direct alignability of the resulting reference networks. In addition the dynamic signalling events under drought stress will be analysed. Using a combination of network alignment, graph theoretical and statistical analyses, data integration, and literature-informed criteria a ranked candidate list of stress response regulators will be assembled. These will be genetically and biotechnologically validated. First level candidates will be tested in Arabidopsis thaliana and evaluated with respect to stress tolerance and overall biomass production. The most promising targets will then be transferred to Brassica napus to evaluate the performance in a commercially relevant crop. Champ scientifique natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesevolutionary biologymedical and health scienceshealth sciencesnutritionagricultural sciencesagriculture, forestry, and fisheriesagriculturenatural sciencesearth and related environmental sciencesatmospheric sciencesclimatologyclimatic changes Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Thème(s) ERC-CoG-2014 - ERC Consolidator Grant Appel à propositions ERC-2014-CoG Voir d’autres projets de cet appel Régime de financement ERC-COG - Consolidator Grant Institution d’accueil HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Contribution nette de l'UE € 1 437 046,26 Adresse INGOLSTADTER LANDSTRASSE 1 85764 Neuherberg Allemagne Voir sur la carte Région Bayern Oberbayern München, Landkreis Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 437 046,26 Bénéficiaires (2) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Allemagne Contribution nette de l'UE € 1 437 046,26 Adresse INGOLSTADTER LANDSTRASSE 1 85764 Neuherberg Voir sur la carte Région Bayern Oberbayern München, Landkreis Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 437 046,26 TECHNISCHE UNIVERSITAET MUENCHEN Allemagne Contribution nette de l'UE € 559 703,74 Adresse Arcisstrasse 21 80333 Muenchen Voir sur la carte Région Bayern Oberbayern München, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 559 703,74