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Protein-excipient Interactions and Protein-Protein Interactions in formulation

Objective

The revolution of biotechnology has led to the creation of various types of therapeutic biologics with the potential to provide treatment for new chronic and malignant diseases. Though the potential advantages of biologics lay in their high specificity and potency combined with few side effects, their formulation still remains a large challenge to pharmaceutical scientists. This is in part due to the complex, not-well understood relationship between the physicochemical properties of proteins and formulation conditions required for protein stability. A comprehensive understanding of the molecular mechanisms behind protein stabilization and solubility would provide the formulation scientists with knowledge of the interplay between formulation and stability that in turn could potentially make formulation development faster, cheaper and less labour intensive than the currently used broad screening approach. Understanding the susceptibilities of formulations to protein aggregation and denaturation can reduce the response time to for instance product failure. Few universities in Europe have formulation of biologics as a scientific subject. Consequently, the pharmaceutical industry is forced to train scientists - a challenge for larger companies, and an insurmountable task for smaller companies. Scientists in the field of structural biology, biophysics, protein formulation and stability have formed a consortium to systematically map physicochemical properties of biologics, formulation conditions and protein stability. The main objective of the consortium is to provide a new generation of innovative and entrepreneurial early-stage researchers that will develop methodologies, tools and databases to guide the formulation of robust biologics. The consortium will not only provide an excellent platform to train a new generation of formulation scientists, but also establish avenues for designing new formulation strategies and thereby securing the leading edge of EU expertise.

Field of science

  • /natural sciences/computer and information sciences/databases
  • /natural sciences/biological sciences/biophysics
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/biological sciences/molecular biology/structural biology

Call for proposal

H2020-MSCA-ITN-2015
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

DANMARKS TEKNISKE UNIVERSITET
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Denmark
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 580 163,76

Participants (7)

THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 546 575,76
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 747 649,44
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
LUNDS UNIVERSITET
Sweden
EU contribution
€ 527 318,64
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
NOVOZYMES A/S
Denmark
EU contribution
€ 580 163,76
Address
Krogshoejvej 36
2880 Bagsvaerd
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
WYATT TECHNOLOGY EUROPE GMBH
Germany
EU contribution
€ 249 216,48
Address
Hochstrasse 12A
56307 Dernbach
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MEDIMMUNE LIMITED
United Kingdom
EU contribution
€ 546 575,76
Address
Milstein Building Granta Park
CB21 6GH Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 290 081,88
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments

Partners (2)

MAX IV Laboratory, Lund University
Sweden
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
NANOTEMPER TECHNOLOGIES GMBH
Germany
Address
Flossergasse 4
81369 Munchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)