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Protein-excipient Interactions and Protein-Protein Interactions in formulation

Objective

The revolution of biotechnology has led to the creation of various types of therapeutic biologics with the potential to provide treatment for new chronic and malignant diseases. Though the potential advantages of biologics lay in their high specificity and potency combined with few side effects, their formulation still remains a large challenge to pharmaceutical scientists. This is in part due to the complex, not-well understood relationship between the physicochemical properties of proteins and formulation conditions required for protein stability. A comprehensive understanding of the molecular mechanisms behind protein stabilization and solubility would provide the formulation scientists with knowledge of the interplay between formulation and stability that in turn could potentially make formulation development faster, cheaper and less labour intensive than the currently used broad screening approach. Understanding the susceptibilities of formulations to protein aggregation and denaturation can reduce the response time to for instance product failure. Few universities in Europe have formulation of biologics as a scientific subject. Consequently, the pharmaceutical industry is forced to train scientists - a challenge for larger companies, and an insurmountable task for smaller companies. Scientists in the field of structural biology, biophysics, protein formulation and stability have formed a consortium to systematically map physicochemical properties of biologics, formulation conditions and protein stability. The main objective of the consortium is to provide a new generation of innovative and entrepreneurial early-stage researchers that will develop methodologies, tools and databases to guide the formulation of robust biologics. The consortium will not only provide an excellent platform to train a new generation of formulation scientists, but also establish avenues for designing new formulation strategies and thereby securing the leading edge of EU expertise.

Coordinator

DANMARKS TEKNISKE UNIVERSITET
Net EU contribution
€ 580 163,76
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Denmark

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Region
Danmark Hovedstaden Københavns omegn
Activity type
Higher or Secondary Education Establishments
Other funding
€ 580 163,76

Participants (7)

THE UNIVERSITY OF MANCHESTER
United Kingdom
Net EU contribution
€ 546 575,76
Address
Oxford Road
M13 9PL Manchester

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Region
North West (England) Greater Manchester Manchester
Activity type
Higher or Secondary Education Establishments
Other funding
€ 546 575,76
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
Net EU contribution
€ 747 649,44
Address
Geschwister Scholl Platz 1
80539 Muenchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 747 649,44
LUNDS UNIVERSITET
Sweden
Net EU contribution
€ 527 318,64
Address
Paradisgatan 5c
22100 Lund

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Region
Södra Sverige Sydsverige Skåne län
Activity type
Higher or Secondary Education Establishments
Other funding
€ 527 318,64
NOVOZYMES A/S
Denmark
Net EU contribution
€ 580 163,76
Address
Krogshoejvej 36
2880 Bagsvaerd

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Region
Danmark Hovedstaden Københavns omegn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 580 163,76
WYATT TECHNOLOGY EUROPE GMBH
Germany
Net EU contribution
€ 249 216,48
Address
Hochstrasse 12a
56307 Dernbach

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Rheinland-Pfalz Koblenz Neuwied
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 249 216,48
MEDIMMUNE LIMITED
United Kingdom
Net EU contribution
€ 546 575,76
Address
Milstein Building Granta Park
CB21 6GH Cambridge

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Region
East of England East Anglia Cambridgeshire CC
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 546 575,76
KOBENHAVNS UNIVERSITET
Denmark
Net EU contribution
€ 290 081,88
Address
Norregade 10
1165 Kobenhavn

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Region
Danmark Hovedstaden Byen København
Activity type
Higher or Secondary Education Establishments
Other funding
€ 290 081,88

Partners (2)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

MAX IV Laboratory, Lund University
Sweden
Net EU contribution
€ 0,00
Address
Paradisgatan 5c
22100 Lund

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Region
Södra Sverige Sydsverige Skåne län
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

NANOTEMPER TECHNOLOGIES GMBH
Germany
Net EU contribution
€ 0,00
Address
Flossergasse 4
81369 Munchen

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00