Deliverables
Publication results in Scientific journals and at international conferences and workshops. Easy-to-read information material for the society at large.
Aggregation propensity assessed for all proteinsAggregation propensity - including surface induced aggregation propensity - assessed for all proteins.
Weak and strong protein-protein and protein-excipient interactions are identified.For all proteins in the library the relevant weak and strong protein-protein and protein-excipient interactions are identified.
Structures based on measurements and modelingFor all soluble proteins, there will be at least 1 but preferable 2 or more solution structures based on SAXS measurements and in-silico modeling
Tagg and Tgel are determined for each proteinFor each protein the determination of the temperature of aggregation, Tagg, and gelation, Tgel, using light scattering experiments, differential scanning calorimetry and temperature ramp rheology Measurements.
Protocols for the making of screens 1 and 2 establishedA general protocol for the making of the screens 1 and 2 that are used for all proteins should be ready
International conferenceInternational conferences with contribution from all ESRs as well as external contributions.
Model for the prediction of protein aggregation and stabilityA general model for the prediction of protein aggregation and stability of all proteins
Database with web-based graphical interface will be made public accessible
Project websiteEstablishment of a PIPPI website with a password protected area and a publically accessible area.
For all ESRs a personal carrier Development plan will be ready.
Periodic, financial and final reports to the ECReports will be delivered to the EC periodically. This covers also the Financial reports. A report will be given in when the project finishes.
Evaluation report on training activitiesFor all training activities an evaluation report will be ready
Publications
Author(s):
Matja Zalar, Hristo Svilenov, Alexander Golovanov
Published in:
European Journal of Pharmaceutics and Biopharmaceutics, 2020, Page(s) 127-136, ISSN 0939-6411
Publisher:
Elsevier BV
DOI:
10.1016/j.ejpb.2020.04.002
Author(s):
Christin Pohl, Matja Zalar, Inas El Bialy, Sowmya Indrakumar, Günther H. J. Peters, Wolfgang Friess, Alexander P. Golovanov, Werner W. Streicher, Allan Noergaard, and Pernille Harris
Published in:
Molecular Pharmaceutics, 2020, ISSN 1543-8384
Publisher:
American Chemical Society
DOI:
10.1021/acs.molpharmaceut.0c00406
Author(s):
Sujata Mahapatra, Marco Polimeni, Lorenzo Gentiluomo , Dierk Roessner , Wolfgang Frieß , Günther H J Peters , Werner W Streicher , Mikael Lund , Pernille Harris
Published in:
Molecular Pharmaceutics, 2022, ISSN 1543-8384
Publisher:
American Chemical Society
DOI:
10.1021/acs.molpharmaceut.1c00627
Author(s):
Lorenzo Gentiluomo; Dierk Roessner, Wolfgan Frieß
Published in:
International Journal of Pharmaceutics, 2020, ISSN 0378-5173
Publisher:
Elsevier BV
DOI:
10.1016/j.ijpharm.2020.119039
Author(s):
Roche, A., Gentiluomo, L., Sibanda, N., Roessner, D., Friess, W., Trainoff, S. P., & Curtis, R.
Published in:
Journal of Colloid and Interface Science, 2022, ISSN 0021-9797
Publisher:
Academic Press
DOI:
10.1016/j.jcis.2021.08.191
Author(s):
Hristo Svilenov, Uroš Markoja, Gerhard Winter
Published in:
European Journal of Pharmaceutics and Biopharmaceutics, Issue 125, 2018, Page(s) 106-113, ISSN 0939-6411
Publisher:
Elsevier BV
DOI:
10.1016/j.ejpb.2018.01.004
Author(s):
Hristo Svilenov, Lorenzo Gentiluomo, Wolfgang Friess, Dierk Roessner, Gerhard Winter
Published in:
Journal of Pharmaceutical Sciences, Issue 107/12, 2018, Page(s) 3007-3013, ISSN 0022-3549
Publisher:
John Wiley & Sons Inc.
DOI:
10.1016/j.xphs.2018.08.004
Author(s):
Matja Zalar, Alexander P. Golovanov
Published in:
ACS Omega, Issue 4/19, 2019, Page(s) 18248-18256, ISSN 2470-1343
Publisher:
Americal Chemical Society
DOI:
10.1021/acsomega.9b02269
Author(s):
Roberto Fernandez-Alvarez, Žiga Medoš, Zdeněk Tošner, Alexander Zhigunov, Mariusz Uchman, Stefan Hervø-Hansen, Mikael Lund, Marija Bešter-Rogač, Pavel Matějíček
Published in:
Langmuir, Issue 34/47, 2018, Page(s) 14448-14457, ISSN 0743-7463
Publisher:
American Chemical Society
DOI:
10.1021/acs.langmuir.8b03462
Author(s):
Sowmya Indrakumar, Matja Zalar, Christin Pohl, Allan Nørgaard, Werner Streicher, Pernille Harris, Alexander P. Golovanov, Günther H.J. Peters
Published in:
The Journal of Physical Chemistry B, Issue 123/23, 2019, Page(s) 4867-4877, ISSN 1520-6106
Publisher:
American Chemical Society
DOI:
10.1021/acs.jpcb.9b02370
Author(s):
Matja Zalar, Sowmya Indrakumar, Colin W. Levy, Richard B. Tunnicliffe, Günther H. J. Peters, Alexander P. Golovanov
Published in:
Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/s41598-019-45565-6
Author(s):
Dillen Augustijn, Sujata Mahapatra, Werner Streicher, Hristo Svilenov, Alina Kulakova, Christin Pohl, Åsmund Rinnan
Published in:
European Journal of Pharmaceutics and Biopharmaceutics, Issue 142, 2019, Page(s) 506-517, ISSN 0939-6411
Publisher:
Elsevier BV
DOI:
10.1016/j.ejpb.2019.06.001
Author(s):
Marcello Martinez Morales, Matja Zalar, Silvia Sonzini, Alexander P. Golovanov, Christopher F. van der Walle, Jeremy P. Derrick
Published in:
Molecular Pharmaceutics, Issue 16/7, 2019, Page(s) 3100-3108, ISSN 1543-8384
Publisher:
American Chemical Society
DOI:
10.1021/acs.molpharmaceut.9b00338
Author(s):
Hristo Svilenov, Gerhard Winter
Published in:
European Journal of Pharmaceutics and Biopharmaceutics, Issue 137, 2019, Page(s) 131-139, ISSN 0939-6411
Publisher:
Elsevier BV
DOI:
10.1016/j.ejpb.2019.02.018
Author(s):
Silvia Sonzini, Maria Laura Greco, Thais Cailleau, Lauren Adams, Luke Masterson, Balakumar Vijayakrishnan, Conor Barry, Phillip Howard, Peter Ravn, Christopher F. van der Walle
Published in:
Bioconjugate Chemistry, 2019, ISSN 1043-1802
Publisher:
American Chemical Society
DOI:
10.1021/acs.bioconjchem.9b00809
Author(s):
Hristo Svilenov, Gerhard Winter
Published in:
International Journal of Pharmaceutics, Issue 562, 2019, Page(s) 42-50, ISSN 0378-5173
Publisher:
Elsevier BV
DOI:
10.1016/j.ijpharm.2019.03.025
Author(s):
Lorenzo Gentiluomo, Vanessa Schneider, Dierk Roessner, Wolfgang Frieß
Published in:
Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/s41598-019-51233-6
Author(s):
Andreas Tosstorff, Tim Menzen, Gerhard Winter
Published in:
Journal of Pharmaceutical Sciences, Issue 109/1, 2020, Page(s) 301-307, ISSN 0022-3549
Publisher:
John Wiley & Sons Inc.
DOI:
10.1016/j.xphs.2019.10.057
Author(s):
Alina Kulakova, Sowmya Indrakumar, Pernille Sønderby, Lorenzo Gentiluomo, Werner Streicher, Dierk Roessner, Wolfgang Frieß, Günther H.J. Peters, Pernille Harris
Published in:
Journal of Structural Biology: X, Issue 4, 2020, Page(s) 100017, ISSN 2590-1524
Publisher:
Elsevier
DOI:
10.1016/j.yjsbx.2019.100017
Author(s):
Lorenzo Gentiluomo, Hristo L. Svilenov, Dillen Augustijn, Inas El Bialy, Maria Laura Greco, Alina Kulakova, Sowmya Indrakumar, Sujata Mahapatra, Marcello Martinez Morales, Christin Pohl, Aisling Roche, Andreas Tosstorff, Robin Curtis, Jeremy P. Derrick, Allan Nørgaard, Tarik A. Khan, Günther H. J. Peters, Alain Pluen, Åsmund Rinnan, Werner W. Streicher, Christopher F. van der Walle, Shahid Uddi
Published in:
Molecular Pharmaceutics, 2020, ISSN 1543-8384
Publisher:
American Chemical Society
DOI:
10.1021/acs.molpharmaceut.9b00852
Author(s):
Max Hebditch, Aisling Roche, Robin A. Curtis, Jim Warwicker
Published in:
Journal of Pharmaceutical Sciences, Issue 108/4, 2019, Page(s) 1434-1441, ISSN 0022-3549
Publisher:
John Wiley & Sons Inc.
DOI:
10.1016/j.xphs.2018.11.035
Author(s):
Lorenzo Gentiluomo, Dierk Roessner, Werner Streicher, Sujata Mahapatra, Pernille Harris, Wolfgang Frieß
Published in:
Journal of Pharmaceutical Sciences, Issue 109/1, 2020, Page(s) 443-451, ISSN 0022-3549
Publisher:
John Wiley & Sons Inc.
DOI:
10.1016/j.xphs.2019.09.021
Author(s):
Lorenzo Gentiluomo, Dierk Roessner, Dillen Augustijn, Hristo Svilenov, Alina Kulakova, Sujata Mahapatra, Gerhard Winter, Werner Streicher, Åsmund Rinnan, Günther H.J. Peters, Pernille Harris, Wolfgang Frieß
Published in:
European Journal of Pharmaceutics and Biopharmaceutics, Issue 141, 2019, Page(s) 81-89, ISSN 0939-6411
Publisher:
Elsevier BV
DOI:
10.1016/j.ejpb.2019.05.017
Author(s):
Hristo L. Svilenov, Alina Kulakova, Matja Zalar, Alexander P. Golovanov, Pernille Harris, Gerhard Winter
Published in:
Journal of Pharmaceutical Sciences, Issue 109/1, 2020, Page(s) 584-594, ISSN 0022-3549
Publisher:
John Wiley & Sons Inc.
DOI:
10.1016/j.xphs.2019.10.065
Author(s):
Andreas Tosstorff, Hristo Svilenov, Günther H.J. Peters, Pernille Harris, Gerhard Winter
Published in:
European Journal of Pharmaceutics and Biopharmaceutics, Issue 144, 2019, Page(s) 207-216, ISSN 0939-6411
Publisher:
Elsevier BV
DOI:
10.1016/j.ejpb.2019.09.010
Author(s):
Priyanka Singh, Aisling Roche, Christopher F. van der Walle, Shahid Uddin, Jiali Du, Jim Warwicker, Alain Pluen, Robin Curtis
Published in:
Molecular Pharmaceutics, Issue 16/12, 2019, Page(s) 4775-4786, ISSN 1543-8384
Publisher:
American Chemical Society
DOI:
10.1021/acs.molpharmaceut.9b00430
Author(s):
Hristo Svilenov, Tim Menzen, Klaus Richter, Gerhard Winter
Published in:
Molecular Pharmaceutics, 2020, Page(s) 2638-2647, ISSN 1543-8392
Publisher:
American Chemical Association
DOI:
10.1021/acs.molpharmaceut.0c00330
Author(s):
Pernille Harris
Published in:
Impact, Issue 2017/8, 2017, Page(s) 75-77, ISSN 2398-7073
Publisher:
Science Impact Ltd
DOI:
10.21820/23987073.2017.8.75
Author(s):
A. Kulakova, S. Indrakumar, P. Sønderby, L. Gentiluomo, W. Streicher, D. Roessner, W. Frieß, G. H.J.
Peters, P. Harris
Published in:
bioRxiv, 2019
Publisher:
Cold Spring Harbor Laborator
DOI:
10.1101/742957
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