Protein-excipient Interactions and Protein-Protein Interactions in formulation

Publication results in Scientific journals and at international conferences and workshops. Easy-to-read information material for the society at large.

Aggregation propensity - including surface induced aggregation propensity - assessed for all proteins.

For all proteins in the library the relevant weak and strong protein-protein and protein-excipient interactions are identified.

For all soluble proteins, there will be at least 1 but preferable 2 or more solution structures based on SAXS measurements and in-silico modeling

For each protein the determination of the temperature of aggregation, Tagg, and gelation, Tgel, using light scattering experiments, differential scanning calorimetry and temperature ramp rheology Measurements.

A general protocol for the making of the screens 1 and 2 that are used for all proteins should be ready

International conferences with contribution from all ESRs as well as external contributions.

A general model for the prediction of protein aggregation and stability of all proteins

Database with web-based graphical interface will be made public accessible

Establishment of a PIPPI website with a password protected area and a publically accessible area.

For all ESRs a personal carrier Development plan will be ready.

Reports will be delivered to the EC periodically. This covers also the Financial reports. A report will be given in when the project finishes.

For all training activities an evaluation report will be ready

Author(s): Hristo Svilenov, Uroš Markoja, Gerhard Winter
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 125, 2018, Page(s) 106-113, ISSN 0939-6411
DOI: 10.1016/j.ejpb.2018.01.004

Published in: ISSN 0022-3549
DOI: 10.1016/j.xphs.2018.08.004

Author(s): Matja Zalar, Alexander P. Golovanov
Published in: ACS Omega, Issue 4/19, 2019, Page(s) 18248-18256, ISSN 2470-1343
DOI: 10.1021/acsomega.9b02269

Author(s): Roberto Fernandez-Alvarez, Žiga Medoš, Zdeněk Tošner, Alexander Zhigunov, Mariusz Uchman, Stefan Hervø-Hansen, Mikael Lund, Marija Bešter-Rogač, Pavel Matějíček
Published in: Langmuir, Issue 34/47, 2018, Page(s) 14448-14457, ISSN 0743-7463
DOI: 10.1021/acs.langmuir.8b03462

Author(s): Sowmya Indrakumar, Matja Zalar, Christin Pohl, Allan Nørgaard, Werner Streicher, Pernille Harris, Alexander P. Golovanov, Günther H.J. Peters
Published in: The Journal of Physical Chemistry B, Issue 123/23, 2019, Page(s) 4867-4877, ISSN 1520-6106
DOI: 10.1021/acs.jpcb.9b02370

Author(s): Matja Zalar, Sowmya Indrakumar, Colin W. Levy, Richard B. Tunnicliffe, Günther H. J. Peters, Alexander P. Golovanov
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-45565-6

Author(s): Dillen Augustijn, Sujata Mahapatra, Werner Streicher, Hristo Svilenov, Alina Kulakova, Christin Pohl, Åsmund Rinnan
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 142, 2019, Page(s) 506-517, ISSN 0939-6411
DOI: 10.1016/j.ejpb.2019.06.001

Author(s): Marcello Martinez Morales, Matja Zalar, Silvia Sonzini, Alexander P. Golovanov, Christopher F. van der Walle, Jeremy P. Derrick
Published in: Molecular Pharmaceutics, Issue 16/7, 2019, Page(s) 3100-3108, ISSN 1543-8384
DOI: 10.1021/acs.molpharmaceut.9b00338

Author(s): Hristo Svilenov, Gerhard Winter
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 137, 2019, Page(s) 131-139, ISSN 0939-6411
DOI: 10.1016/j.ejpb.2019.02.018

Author(s): Silvia Sonzini, Maria Laura Greco, Thais Cailleau, Lauren Adams, Luke Masterson, Balakumar Vijayakrishnan, Conor Barry, Phillip Howard, Peter Ravn, Christopher F. van der Walle
Published in: Bioconjugate Chemistry, 2019, ISSN 1043-1802
DOI: 10.1021/acs.bioconjchem.9b00809

Author(s): Hristo Svilenov, Gerhard Winter
Published in: International Journal of Pharmaceutics, Issue 562, 2019, Page(s) 42-50, ISSN 0378-5173
DOI: 10.1016/j.ijpharm.2019.03.025

Author(s): Lorenzo Gentiluomo, Vanessa Schneider, Dierk Roessner, Wolfgang Frieß
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-51233-6

Published in: ISSN 0022-3549
DOI: 10.1016/j.xphs.2019.10.057

Author(s): Alina Kulakova, Sowmya Indrakumar, Pernille Sønderby, Lorenzo Gentiluomo, Werner Streicher, Dierk Roessner, Wolfgang Frieß, Günther H.J. Peters, Pernille Harris
Published in: Journal of Structural Biology: X, Issue 4, 2020, Page(s) 100017, ISSN 2590-1524
DOI: 10.1016/j.yjsbx.2019.100017

Author(s): Lorenzo Gentiluomo, Hristo L. Svilenov, Dillen Augustijn, Inas El Bialy, Maria Laura Greco, Alina Kulakova, Sowmya Indrakumar, Sujata Mahapatra, Marcello Martinez Morales, Christin Pohl, Aisling Roche, Andreas Tosstorff, Robin Curtis, Jeremy P. Derrick, Allan Nørgaard, Tarik A. Khan, Günther H. J. Peters, Alain Pluen, Åsmund Rinnan, Werner W. Streicher, Christopher F. van der Walle, Shahid Uddi
Published in: Molecular Pharmaceutics, 2020, ISSN 1543-8384
DOI: 10.1021/acs.molpharmaceut.9b00852

Published in: ISSN 0022-3549
DOI: 10.1016/j.xphs.2018.11.035

Published in: ISSN 0022-3549
DOI: 10.1016/j.xphs.2019.09.021

Author(s): Lorenzo Gentiluomo, Dierk Roessner, Dillen Augustijn, Hristo Svilenov, Alina Kulakova, Sujata Mahapatra, Gerhard Winter, Werner Streicher, Åsmund Rinnan, Günther H.J. Peters, Pernille Harris, Wolfgang Frieß
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 141, 2019, Page(s) 81-89, ISSN 0939-6411
DOI: 10.1016/j.ejpb.2019.05.017

Published in: ISSN 0022-3549
DOI: 10.1016/j.xphs.2019.10.065

Author(s): Andreas Tosstorff, Hristo Svilenov, Günther H.J. Peters, Pernille Harris, Gerhard Winter
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 144, 2019, Page(s) 207-216, ISSN 0939-6411
DOI: 10.1016/j.ejpb.2019.09.010

Author(s): Priyanka Singh, Aisling Roche, Christopher F. van der Walle, Shahid Uddin, Jiali Du, Jim Warwicker, Alain Pluen, Robin Curtis
Published in: Molecular Pharmaceutics, Issue 16/12, 2019, Page(s) 4775-4786, ISSN 1543-8384
DOI: 10.1021/acs.molpharmaceut.9b00430

Author(s): Pernille Harris
Published in: Impact, Issue 2017/8, 2017, Page(s) 75-77, ISSN 2398-7073
DOI: 10.21820/23987073.2017.8.75

Author(s): A. Kulakova, S. Indrakumar, P. Sønderby, L. Gentiluomo, W. Streicher, D. Roessner, W. Frieß, G. H.J. Peters, P. Harris
Published in: bioRxiv, 2019
DOI: 10.1101/742957