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Imaging the Force of Cancer

Objective

Cancer is the second leading cause of mortality in EU member states with ~90% of all cancer deaths caused by metastatic spread. Despite its significance, measuring metastatic potential as well as potential indicators of therapy efficacy remain unmet clinical challenges. Recently, it has been demonstrated in vitro, that aggressive metastatic cells pull on their surroundings suggesting that metastatic potential could be gauged by measuring the forces exert by tumours. Furthermore, many solid tumours show a significantly increased interstitial fluid pressure (IFP) which prevents the efficient uptake of therapeutic agents. As a result, a reduction in IFP is recognized as a hallmark of therapeutic efficacy. Currently, there is no non-invasive modality that can directly image these forces in vivo.
Our objective is the non-invasive measurement of both IFP within tumours as well as the forces they exert on their surrounding environment. This will be used to predict a tumour’s metastatic potential and importantly, changes in these forces will be used to predict the therapeutic efficacy of drug therapy. To attain this goal, the biomechanical properties of the tumour and its neighbouring tissue will be measured via MR-elastography at various measured deformation states. Resultant images will be used to reconstruct images of the internal and external forces acting on the tumour. We call this novel imaging modality Magnetic Resonance Force (MRF) imaging .
We will calibrate MRF via cell cultures and pre-clinical models, and then test the method in breast, liver, and brain cancer patients. Thereby, we will investigate whether MRF data can predict metastatic spread and measure IFP in patients. We will also investigate the potential to non-invasively modulate the force environment of cancer cells via externally applied shear forces with the aim of impacting cell motility and proliferation. This can provide novel mechanism for anticancer therapeutic agents via mechanotransduction.

Call for proposal

H2020-PHC-2014-2015

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Sub call

H2020-PHC-2015-two-stage

Coordinator

KING'S COLLEGE LONDON
Net EU contribution
€ 2 196 560,00
Address
Strand
WC2R 2LS London
United Kingdom

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (19)

THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
United Kingdom
Net EU contribution
€ 631 701,25
Address
Old Brompton Road 123
SW7 3RP London

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
Net EU contribution
€ 0,00
Address
Raemistrasse 101
8092 Zuerich

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 805 697,50
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
Net EU contribution
€ 515 000,00
Address
Chariteplatz 1
10117 Berlin

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Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 328 270,00
Address
Rue De Tolbiac 101
75654 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITE PARIS CITE
France
Net EU contribution
€ 14 830,00
Address
85 Bd Saint Germain
75006 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
Net EU contribution
€ 271 020,00
Address
3 Avenue Victoria
75000 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITAT BASEL
Switzerland
Net EU contribution
€ 0,00
Address
Petersplatz 1
4051 Basel

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 546 153,75
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITATSSPITAL BASEL
Switzerland
Net EU contribution
€ 0,00
Address
Hebelstrasse 32
4031 Basel

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 78 633,75
UNIVERSITETET I OSLO
Norway
Net EU contribution
€ 603 200,00
Address
Problemveien 5-7
0313 Oslo

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Region
Norge Oslo og Viken Oslo
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

OSLO UNIVERSITETSSYKEHUS HF
Norway
Net EU contribution
€ 127 800,00
Address
Kirkeveien 166 Tarnbygget
0450 Oslo

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Region
Norge Oslo og Viken Oslo
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAET LEIPZIG
Germany
Net EU contribution
€ 503 500,00
Address
Ritterstrasse 26
04109 Leipzig

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Region
Sachsen Leipzig Leipzig
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
SCREENCELL

Participation ended

France
Net EU contribution
€ 322 500,00
Address
10 Avenue Charles Peguy Centre Roger Perez
95200 Sarcelles

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ile-de-France Ile-de-France Val-d’Oise
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
CERMAKOVA IVA
Germany
Net EU contribution
€ 150 375,00
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
INTEGRATED TECHNOLOGIES LIMITED
United Kingdom
Net EU contribution
€ 98 500,00
Address
Viking House Ellingham Way
TN23 6NF Ashford

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
South East (England) Kent Mid Kent
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
PHILIPS MEDICAL SYSTEMS NEDERLAND BV
Netherlands
Net EU contribution
€ 0,00
Address
Veenpluis 6
5684 PC Best

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Region
Noord-Brabant Zuidoost-Noord-Brabant
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 25 000,00
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
France
Net EU contribution
€ 0,00
Address
Pierre Brossolette 1
91380 Chilly Mazarin

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Region
Ile-de-France Ile-de-France Essonne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 100 000,00
UNIVERSITY OF NEW SOUTH WALES
Australia
Net EU contribution
€ 0,00
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

NEUROSCIENCE RESEARCH ASUTRALIA
Australia
Net EU contribution
€ 0,00
Non-EU contribution
€ 50 000,00
THE BRIGHAM AND WOMEN'S HOSPITAL INC
United States
Net EU contribution
€ 49 375,00
Non-EU contribution
€ 0,00