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Imaging the Force of Cancer

Deliverables

Final report on liver cancer metastasis models

This report will demonstrate the degree to which MRF derived biomarkers can predict the development of metastasis in a liver cancer model

Report on results from preclinical trials

Results from in vivo tests on orthotopically implanted tumours or experimental metastasis in mice using both research scanner and commercial scanner. The aim is to verify results from the in vitro experiments.

Final report on MRF sequences development and results
Final report on clinical study and value of MRF to predict MVI.

This final report after the 6 months of allowing for final data analysis will show the value MRF provides for predicting the presenceabsence of MVI in HCC This report will also refer to the resultsobtained via ScreenCell and establish whether a combination of CTC derived information plus MRF derived biomarkers has the potential to further improve the prediction of MVI

Final report on IFP/active force reconstruction method

The Integrity of invasive IFP measurements in vitro active force data from TFM measurements on tumour spheroids and preclinical tumours as well as histopathological results from preclinical and clinical tumour cases allows to optimize and finalize the force reconstruction

Final report on clinical study

This final report after the 6 months of allowing for final data analysis will show the value MRF provides for predicting the presenceabsence of lympnode involvement It will further demonstrate the value of IFP quantified via MRF for predicting response to therapy in this cohort of patients Correlation to results obtained via ScreenCell will provide further insight into the question whether CTC data help to increase the ability of MRF derived imaging biomarkers to predict metastatic potential

Final report on clinical study and value of MRF in brain tumour delineation

This final report after the 6 months of allowing for final data analysis will show the value that MRF provides for predicting the presenceabsence and delineation of tumour cells in primary brain tumours and metastases This report will also refer to the results obtained by conventional means and histopathological correlations

Final Report on ability of MRF derived IFP for predicting response to therapy in liver cancer models
Final report on CTC analysis for HCC

ScreenCell will summarize its findings and show to which degree advanced CTC analysis in combination with MRF derived imaging biomarkers enhance the sensitivity to predict microvascular involvement for HCC It will also summarize how the TFM findings correlate to the histopathological results of the individual tumour specimen

Final report on beast and brain cancer metastasis models

This report will demonstrate the degree to which MRF derived biomarkers can predict the development of metastasis in breast and brain cancer model

Report on clinical MRF protocol for breast

After 14 month KCL has collected data about the reproducibility, stability, and precision of the current MRF protocol

Final report on TFM results

This report will demonstrate the degree to which TFM derived force measurements correlate with MRF derived values. This represents an important step in the validation of MRF for being able to actually measure the active forces of a tumour exerted onto its habitat.

Publications

Collagen is a major determinant of the viscoelasticity properties of stromal dense tumours: insights from pre-clinical MRE

Author(s): Jin Li, Konstantinos Zormpas-Petridis, Andreas Heindl, Jessica K.R. Boult, Craig Cummings, Jeffrey C. Bamber, Yinyin Yuan, Ralph Sinkus, Yann Jamin, Simon P. Robinson
Published in: Proceedings of the Annual Meeting of the International Society for Magnetic Resonance in Medicine, 2018, Page(s) "Abstr #629"
Publisher: ISMRM

Stiffness, measured by magnetic resonance elastography (MRE), correlates with collagen content in stromal dense tumours

Author(s): Emma Reeves, Jin Li, Konstantinos Zormpas-Petridis, Andreas Heindl, Jessica K.R. Boult, Craig Cummings, Jeffrey C. Bamber, Yinyin Yuan, Ralph Sinkus, Yann Jamin, Simon P. Robinson
Published in: Forces in Cancer: interdisciplinary approaches in tumour mechanobiology, 2018
Publisher: The Royal Society

Imaging biomarker roadmap for cancer studies

Author(s): James P. B. O'Connor, Eric O. Aboagye, Judith E. Adams, Hugo J. W. L. Aerts, Sally F. Barrington, Ambros J. Beer, Ronald Boellaard, Sarah E. Bohndiek, Michael Brady, Gina Brown, David L. Buckley, Thomas L. Chenevert, Laurence P. Clarke, Sandra Collette, Gary J. Cook, Nandita M. deSouza, John C. Dickson, Caroline Dive, Jeffrey L. Evelhoch, Corinne Faivre-Finn, Ferdia A. Gallagher, Fiona J. Gilbert,
Published in: Nature Reviews Clinical Oncology, Issue 14/3, 2017, Page(s) 169-186, ISSN 1759-4774
Publisher: Nature Publishing Group
DOI: 10.1038/nrclinonc.2016.162

Jamming transitions in cancer

Author(s): Linda Oswald, Steffen Grosser, David M Smith, Josef A Käs
Published in: Journal of Physics D: Applied Physics, Issue 50/48, 2017, Page(s) 483001, ISSN 0022-3727
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-6463/aa8e83

The two faces of enhanced stroma: Stroma acts as a tumor promoter and a steric obstacle

Author(s): Claudia Tanja Mierke, Frank Sauer, Steffen Grosser, Stefanie Puder, Tony Fischer, Josef Alfons Käs
Published in: NMR in Biomedicine, Issue 31/10, 2018, Page(s) e3831, ISSN 0952-3480
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/nbm.3831

Analysis and improvement of motion encoding in magnetic resonance elastography

Author(s): Guenthner, Christian; Runge, Jurgen Henk; Sinkus, Ralph; Kozerke, Sebastian
Published in: Guenthner, Christian; Runge, Jurgen Henk; Sinkus, Ralph; Kozerke, Sebastian (2018). Analysis and improvement of motion encoding in magnetic resonance elastography. NMR in Biomedicine, 31(5):e3908., Issue 1, 2018, ISSN 0952-3480
Publisher: John Wiley & Sons Inc.
DOI: 10.5167/uzh-159366

Encoding and readout strategies in magnetic resonance elastography

Author(s): Christian Guenthner, Sebastian Kozerke
Published in: NMR in Biomedicine, Issue 31/10, 2018, Page(s) e3919, ISSN 0952-3480
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/nbm.3919

Linking the fractional derivative and the Lomnitz creep law to non-Newtonian time-varying viscosity

Author(s): Vikash Pandey and Sverre Holm
Published in: Physical Review E, Issue Vol. 94, Issue 3, 2016, Page(s) 032606, ISSN 2470-0045
Publisher: American Physical Society
DOI: 10.1103/PhysRevE.94.032606

Stiffness reconstruction methods for MR elastography

Author(s): Daniel Fovargue, David Nordsletten, Ralph Sinkus
Published in: NMR in Biomedicine, Issue 31/10, 2018, Page(s) e3935, ISSN 0952-3480
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/nbm.3935

A novel magnetic resonance elastography transducer concept based on a rotational eccentric mass: preliminary experiences with the gravitational transducer

Author(s): Jurgen Henk Runge, Stefan Heinz Hoelzl, Jelizaveta Sudakova, Ayse Sila Dokumaci, Jules Laurent Nelissen, Christian Guenthner, Jack Lee, Marian Troelstra, Daniel Fovargue, Jaap Stoker, Aart Johannes Nederveen, David Nordsletten, Ralph Sinkus
Published in: Physics in Medicine & Biology, Issue 64/4, 2019, Page(s) 045007, ISSN 1361-6560
Publisher: IOP Publishing
DOI: 10.1088/1361-6560/aaf9f8

Robust MR elastography stiffness quantification using a localized divergence free finite element reconstruction

Author(s): Daniel Fovargue, Sebastian Kozerke, Ralph Sinkus, David Nordsletten
Published in: Medical Image Analysis, Issue 44, 2018, Page(s) 126-142, ISSN 1361-8415
Publisher: Elsevier BV
DOI: 10.1016/j.media.2017.12.005

Imaging localized neuronal activity at fast time scales through biomechanics

Author(s): Samuel Patz, Daniel Fovargue, Katharina Schregel, Navid Nazari, Miklos Palotai, Paul E. Barbone, Ben Fabry, Alexander Hammers, Sverre Holm, Sebastian Kozerke, David Nordsletten, Ralph Sinkus
Published in: Science Advances, Issue 5/4, 2019, Page(s) eaav3816, ISSN 2375-2548
Publisher: Science Advances
DOI: 10.1126/sciadv.aav3816

Perfusion alters stiffness of deep gray matter

Author(s): Stefan Hetzer, Patric Birr, Andreas Fehlner, Sebastian Hirsch, Florian Dittmann, Eric Barnhill, Jürgen Braun, Ingolf Sack
Published in: Journal of Cerebral Blood Flow & Metabolism, 2016, Page(s) 0271678X1769153, ISSN 0271-678X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678X17691530

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