CORDIS provides links to public deliverables and publications of HORIZON projects.
Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .
Deliverables
This report will demonstrate the degree to which MRF derived biomarkers can predict the development of metastasis in a liver cancer model
Report on results from preclinical trials (opens in new window)Results from in vivo tests on orthotopically implanted tumours or experimental metastasis in mice using both research scanner and commercial scanner. The aim is to verify results from the in vitro experiments.
Final report on MRF sequences development and results (opens in new window)Final report on clinical study and value of MRF to predict MVI. (opens in new window)
This final report after the 6 months of allowing for final data analysis will show the value MRF provides for predicting the presenceabsence of MVI in HCC This report will also refer to the resultsobtained via ScreenCell and establish whether a combination of CTC derived information plus MRF derived biomarkers has the potential to further improve the prediction of MVI
Final report on IFP/active force reconstruction method (opens in new window)The Integrity of invasive IFP measurements in vitro active force data from TFM measurements on tumour spheroids and preclinical tumours as well as histopathological results from preclinical and clinical tumour cases allows to optimize and finalize the force reconstruction
Final report on clinical study (opens in new window)This final report after the 6 months of allowing for final data analysis will show the value MRF provides for predicting the presenceabsence of lympnode involvement It will further demonstrate the value of IFP quantified via MRF for predicting response to therapy in this cohort of patients Correlation to results obtained via ScreenCell will provide further insight into the question whether CTC data help to increase the ability of MRF derived imaging biomarkers to predict metastatic potential
Final report on clinical study and value of MRF in brain tumour delineation (opens in new window)This final report after the 6 months of allowing for final data analysis will show the value that MRF provides for predicting the presenceabsence and delineation of tumour cells in primary brain tumours and metastases This report will also refer to the results obtained by conventional means and histopathological correlations
Final Report on ability of MRF derived IFP for predicting response to therapy in liver cancer models (opens in new window)Final report on CTC analysis for HCC (opens in new window)
ScreenCell will summarize its findings and show to which degree advanced CTC analysis in combination with MRF derived imaging biomarkers enhance the sensitivity to predict microvascular involvement for HCC It will also summarize how the TFM findings correlate to the histopathological results of the individual tumour specimen
Final report on beast and brain cancer metastasis models (opens in new window)This report will demonstrate the degree to which MRF derived biomarkers can predict the development of metastasis in breast and brain cancer model
Report on clinical MRF protocol for breast (opens in new window)After 14 month KCL has collected data about the reproducibility, stability, and precision of the current MRF protocol
Final report on TFM results (opens in new window)This report will demonstrate the degree to which TFM derived force measurements correlate with MRF derived values. This represents an important step in the validation of MRF for being able to actually measure the active forces of a tumour exerted onto its habitat.
Publications
Author(s):
Jin Li, Konstantinos Zormpas-Petridis, Andreas Heindl, Jessica K.R. Boult, Craig Cummings, Jeffrey C. Bamber, Yinyin Yuan, Ralph Sinkus, Yann Jamin, Simon P. Robinson
Published in:
Proceedings of the Annual Meeting of the International Society for Magnetic Resonance in Medicine, 2018, Page(s) "Abstr #629"
Publisher:
ISMRM
Author(s):
Emma Reeves, Jin Li, Konstantinos Zormpas-Petridis, Andreas Heindl, Jessica K.R. Boult, Craig Cummings, Jeffrey C. Bamber, Yinyin Yuan, Ralph Sinkus, Yann Jamin, Simon P. Robinson
Published in:
Forces in Cancer: interdisciplinary approaches in tumour mechanobiology, 2018
Publisher:
The Royal Society
Author(s):
James P. B. O'Connor, Eric O. Aboagye, Judith E. Adams, Hugo J. W. L. Aerts, Sally F. Barrington, Ambros J. Beer, Ronald Boellaard, Sarah E. Bohndiek, Michael Brady, Gina Brown, David L. Buckley, Thomas L. Chenevert, Laurence P. Clarke, Sandra Collette, Gary J. Cook, Nandita M. deSouza, John C. Dickson, Caroline Dive, Jeffrey L. Evelhoch, Corinne Faivre-Finn, Ferdia A. Gallagher, Fiona J. Gilbert,
Published in:
Nature Reviews Clinical Oncology, Issue 14/3, 2017, Page(s) 169-186, ISSN 1759-4774
Publisher:
Nature Publishing Group
DOI:
10.1038/nrclinonc.2016.162
Author(s):
Linda Oswald, Steffen Grosser, David M Smith, Josef A Käs
Published in:
Journal of Physics D: Applied Physics, Issue 50/48, 2017, Page(s) 483001, ISSN 0022-3727
Publisher:
Institute of Physics Publishing
DOI:
10.1088/1361-6463/aa8e83
Author(s):
Claudia Tanja Mierke, Frank Sauer, Steffen Grosser, Stefanie Puder, Tony Fischer, Josef Alfons Käs
Published in:
NMR in Biomedicine, Issue 31/10, 2018, Page(s) e3831, ISSN 0952-3480
Publisher:
John Wiley & Sons Inc.
DOI:
10.1002/nbm.3831
Author(s):
Guenthner, Christian; Runge, Jurgen Henk; Sinkus, Ralph; Kozerke, Sebastian
Published in:
Guenthner, Christian; Runge, Jurgen Henk; Sinkus, Ralph; Kozerke, Sebastian (2018). Analysis and improvement of motion encoding in magnetic resonance elastography. NMR in Biomedicine, 31(5):e3908., Issue 1, 2018, ISSN 0952-3480
Publisher:
John Wiley & Sons Inc.
DOI:
10.5167/uzh-159366
Author(s):
Christian Guenthner, Sebastian Kozerke
Published in:
NMR in Biomedicine, Issue 31/10, 2018, Page(s) e3919, ISSN 0952-3480
Publisher:
John Wiley & Sons Inc.
DOI:
10.1002/nbm.3919
Author(s):
Vikash Pandey and Sverre Holm
Published in:
Physical Review E, Issue Vol. 94, Issue 3, 2016, Page(s) 032606, ISSN 2470-0045
Publisher:
American Physical Society
DOI:
10.1103/PhysRevE.94.032606
Author(s):
Daniel Fovargue, David Nordsletten, Ralph Sinkus
Published in:
NMR in Biomedicine, Issue 31/10, 2018, Page(s) e3935, ISSN 0952-3480
Publisher:
John Wiley & Sons Inc.
DOI:
10.1002/nbm.3935
Author(s):
Jurgen Henk Runge, Stefan Heinz Hoelzl, Jelizaveta Sudakova, Ayse Sila Dokumaci, Jules Laurent Nelissen, Christian Guenthner, Jack Lee, Marian Troelstra, Daniel Fovargue, Jaap Stoker, Aart Johannes Nederveen, David Nordsletten, Ralph Sinkus
Published in:
Physics in Medicine & Biology, Issue 64/4, 2019, Page(s) 045007, ISSN 1361-6560
Publisher:
IOP Publishing
DOI:
10.1088/1361-6560/aaf9f8
Author(s):
Daniel Fovargue, Sebastian Kozerke, Ralph Sinkus, David Nordsletten
Published in:
Medical Image Analysis, Issue 44, 2018, Page(s) 126-142, ISSN 1361-8415
Publisher:
Elsevier BV
DOI:
10.1016/j.media.2017.12.005
Author(s):
Samuel Patz, Daniel Fovargue, Katharina Schregel, Navid Nazari, Miklos Palotai, Paul E. Barbone, Ben Fabry, Alexander Hammers, Sverre Holm, Sebastian Kozerke, David Nordsletten, Ralph Sinkus
Published in:
Science Advances, Issue 5/4, 2019, Page(s) eaav3816, ISSN 2375-2548
Publisher:
Science Advances
DOI:
10.1126/sciadv.aav3816
Author(s):
Stefan Hetzer, Patric Birr, Andreas Fehlner, Sebastian Hirsch, Florian Dittmann, Eric Barnhill, Jürgen Braun, Ingolf Sack
Published in:
Journal of Cerebral Blood Flow & Metabolism, 2016, Page(s) 0271678X1769153, ISSN 0271-678X
Publisher:
Lippincott Williams & Wilkins Ltd.
DOI:
10.1177/0271678X17691530
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