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Improving Diagnosis by Fast Field-Cycling MRI

Improving Diagnosis by Fast Field-Cycling MRI

Objective

Many diseases are inadequately diagnosed, or not diagnosed early enough by current imaging methods. Examples of unmet clinical needs arise in thromboembolic disease, osteoarthritis, cancer, sarcopenia, and many more areas. Our solution, Fast Field-Cycling (FFC) MRI, can measure quantitative information that is invisible to standard MRI. FFC scanners switch magnetic field while scanning the patient, obtaining new diagnostic information. FFC-MRI has been demonstrated by us, but many challenges must be solved before clinical adoption.
Objectives:
Understand the mechanisms determining FFC signals in tissues;
Create technology to measure and correct for environmental magnetic fields, enabling FFC at ultra-low fields;
Investigate contrast agents for FFC, to increase sensitivity and to allow molecular imaging;
Improve FFC technology, in order to extend its range of clinical applications;
Test FFC-MRI on tissue samples and on patients.
Achieved by:
Developing the theory of relaxation in tissue at ultra-low fields, leading to models and biomarkers;
Developing magnetometers for FFC-MRI, and environmental-field correction;
Creating and in vitro testing of new FFC contrast agents; studying existing clinical agents for FFC-MRI sensitivity;
Improving technology to monitor and stabilise magnetic fields in FFC; improving magnet power supply stability; investigating better radiofrequency coils and acquisition pulse sequences;
Testing FFC methods on tissue samples from surgery and tissue banks; proof-of-principle scans on patients.
FFC-MRI is a paradigm-shifting technology which will generate new, quantitative disease biomarkers, directly informing and improving clinical diagnosis, treatment decisions and treatment monitoring. Its lower cost contributes to healthcare sustainability. The proposal consolidates the EU lead in FFC technology and uses new concepts from world-leading teams to deliver solutions based on innovations in theory, modelling, physics, chemistry and engineering.
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Coordinator

THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN

Address

King'S College Regent Walk
Ab24 3fx Aberdeen

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 479 853,75

Participants (9)

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INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 633 625

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

EU Contribution

€ 1 173 041,25

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 367 560

UNIVERSITA DEGLI STUDI DI TORINO

Italy

EU Contribution

€ 584 750

UNIWERSYTET WARMINSKO MAZURSKI W OLSZTYNIE

Poland

EU Contribution

€ 321 000

TECHNISCHE UNIVERSITAET ILMENAU

Germany

EU Contribution

€ 442 250

STELAR SRL

Italy

EU Contribution

€ 902 750

INTERNATIONAL ELECTRIC COMPANY OY

Finland

EU Contribution

€ 255 466,25

OY INTERNATIONAL ELECTRIC COMPANY

Finland

EU Contribution

€ 437 081,25

Project information

Grant agreement ID: 668119

Status

Ongoing project

  • Start date

    1 January 2016

  • End date

    31 December 2019

Funded under:

H2020-EU.3.1.3.

  • Overall budget:

    € 6 597 377,50

  • EU contribution

    € 6 597 377,50

Coordinated by:

THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN

United Kingdom