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Improving Diagnosis by Fast Field-Cycling MRI

Objective

Many diseases are inadequately diagnosed, or not diagnosed early enough by current imaging methods. Examples of unmet clinical needs arise in thromboembolic disease, osteoarthritis, cancer, sarcopenia, and many more areas. Our solution, Fast Field-Cycling (FFC) MRI, can measure quantitative information that is invisible to standard MRI. FFC scanners switch magnetic field while scanning the patient, obtaining new diagnostic information. FFC-MRI has been demonstrated by us, but many challenges must be solved before clinical adoption.
Objectives:
Understand the mechanisms determining FFC signals in tissues;
Create technology to measure and correct for environmental magnetic fields, enabling FFC at ultra-low fields;
Investigate contrast agents for FFC, to increase sensitivity and to allow molecular imaging;
Improve FFC technology, in order to extend its range of clinical applications;
Test FFC-MRI on tissue samples and on patients.
Achieved by:
Developing the theory of relaxation in tissue at ultra-low fields, leading to models and biomarkers;
Developing magnetometers for FFC-MRI, and environmental-field correction;
Creating and in vitro testing of new FFC contrast agents; studying existing clinical agents for FFC-MRI sensitivity;
Improving technology to monitor and stabilise magnetic fields in FFC; improving magnet power supply stability; investigating better radiofrequency coils and acquisition pulse sequences;
Testing FFC methods on tissue samples from surgery and tissue banks; proof-of-principle scans on patients.
FFC-MRI is a paradigm-shifting technology which will generate new, quantitative disease biomarkers, directly informing and improving clinical diagnosis, treatment decisions and treatment monitoring. Its lower cost contributes to healthcare sustainability. The proposal consolidates the EU lead in FFC technology and uses new concepts from world-leading teams to deliver solutions based on innovations in theory, modelling, physics, chemistry and engineering.

Call for proposal

H2020-PHC-2015-two-stage
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Coordinator

THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN
Address
King's College Regent Walk
AB24 3FX Aberdeen
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 479 853,75

Participants (9)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 633 625
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 1 173 041,25
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 367 560
Address
Rue Michel Ange 3
75794 Paris
Activity type
Other
UNIVERSITA DEGLI STUDI DI TORINO
Italy
EU contribution
€ 584 750
Address
Via Giuseppe Verdi 8
10124 Torino
Activity type
Higher or Secondary Education Establishments
UNIWERSYTET WARMINSKO MAZURSKI W OLSZTYNIE
Poland
EU contribution
€ 321 000
Address
Ul. Oczapowskiego 2
10 719 Olsztyn
Activity type
Higher or Secondary Education Establishments
TECHNISCHE UNIVERSITAET ILMENAU
Germany
EU contribution
€ 442 250
Address
Ehrenbergstrasse 29
98693 Ilmenau
Activity type
Higher or Secondary Education Establishments
STELAR SRL
Italy
EU contribution
€ 902 750
Address
Via Enrico Fermi 4
27035 Mede
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INTERNATIONAL ELECTRIC COMPANY OY

Participation ended

Finland
EU contribution
€ 255 466,25
Address
Sahaajankatu 48
00880 Helsinki
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
OY INTERNATIONAL ELECTRIC COMPANY
Finland
EU contribution
€ 437 081,25
Address
Sahaajankatu 48
00880 Helsinki
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)