Deliverables
These will be prepared following each Annual Meeting, they will include the main topics of discussion during these events, specifically focusing on major progress milestones and results that can have specific interest to major stakeholders and end-users.
The Project Handbook is to be taken as a collated support document covering all deadlines and procedures related with decision-making structure, financial reporting, corrective actions, and all aspects involved with managing the project. Partners will be provided a copy and it will be periodically reviewed and updated if necessary
Results of pilot studies detecting multi transcript signatures by quantum dot technology.
Results of alternative approaches to detect multi transcript signatures using electro sensors. Evaluation of results from studies in collaboration with POC-ID.
Copies of all approvals from ethics committees and national or regional ethics boards/bodies/administrations to be submitted to the European commission. These include approvals for transfer of biological samples and data between parties and any third party. Ethics approvals must cover approval of local institutions where samples are collected as well as overall national approval
Conceptual model of impact of diagnostic on antimicrobial resistance
Summary report on RNAseq and microarray studies for Discovery group
Overview of recruitment by study site including numbers, recruiting problems and any measures made to compensate if recruitment delays occurred. (Per study)
These will be prepared following each Annual Meeting, they will include the main topics of discussion during these events, specifically focusing on major progress milestones and results that can have specific interest to major stakeholders and end-users.
Copies of consent forms and child assent forms (in each partner language) submitted to confirm compliance with Article 29 workgroup paper WP131 on processing personal data in health records, and confirming that the consent forms cover the right to withdraw from studies including withdrawal of samples and data.
Independent ethics review board submits second report on ethical issues and conduct of the study
These will be prepared following each Annual Meeting, they will include the main topics of discussion during these events, specifically focusing on major progress milestones and results that can have specific interest to major stakeholders and end-users.
Tool-server platforms: allowing computational tools and workflows to be deployed on the integrated data including custom ones developed by project
Will outline the approach PERFORM will take towards the communication of its activities and results to relevant audiences, end-users, policy-makers and stakeholders. The document will include the strategic approach the consortium has selected to maximize the effectiveness and impact of its expected outcomes. It will also include all chosen communication channels and platforms to be developed and used across the duration of the project.
Report on transcriptomic and proteomic signatures that distinguish bacterial and viral infections in the discovery cohort
Reports on provider, parent and costing studies
Initial report of independent ethics review board on the documents for patient consent and the procedures for patient data and sample collection and overall ethical procedures submitted
Report on feasibility and implementation assessment of novel diagnostic
Completion of recruitment and patient assignment for all prospective studies (BIVABI, BIVA- ED, BIVA-PIC, BIVA-INF and MOFICHE); samples and patient data sent for analysis. Includes report on updating the status of study registry.
Report on the performance of individual biomarker proteins
report on the selection of platform to develop prototype diagnostic
Report studies of transcriptomic markers to differentiate febrile patients with bacterial and viral infection in the validation cohorts
Delivery of a range of options based on models on how a novel proteomic or genomic marker would influence patient care flows
report on the outcome of molecular bacterial and viral diagnostic studies
Delivery of operational database, housing clinical and laboratory data
These will be prepared following each Annual Meeting, they will include the main topics of discussion during these events, specifically focusing on major progress milestones and results that can have specific interest to major stakeholders and end-users.
Delivery of Mass spectrometry proteomic analysis on discovery cohort
Clinical recruitment and data collection documents for all prospective studies (BIVABI, BIVA- ED, BIVA-PIC, BIVA-INF and MOFICHE) finalised and agreed by PERFORM consortium. These documents to include the first study subject approvals package – with the final version of study protocol, registration number in an approved registry, ethics approval for main study site.
The project will develop and use a dedicated website to improve engagement with its end-users and stakeholders. It is the aim of the project to keep its website up to date with the latest activities and outcomes, so as to maximize it's impact with regards to the main interested parties.
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Publications
Author(s): Simon Leigh, Alison Grant, Nicola Murray, Brian Faragher, Henal Desai, Samantha Dolan, Naeema Cabdi, James B. Murray, Yasmin Rejaei, Stephanie Stewart, Karl Edwardson, Jason Dean, Bimal Mehta, Shunmay Yeung, Frans Coenen, Louis W. Niessen, Enitan D. Carrol
Published in: BMC Medicine, Issue 17/1, 2019, ISSN 1741-7015
DOI: 10.1186/s12916-019-1275-z
Author(s): Anouk Suppers, Alain van Gool, Hans Wessels
Published in: Proteomes, Issue 6/2, 2018, Page(s) 20, ISSN 2227-7382
DOI: 10.3390/proteomes6020020
Author(s): Hijiri G Suzuki, Juan Emmanuel Dewez, Ruud G Nijman, Shunmay Yeung
Published in: BMJ Open, Issue 10/5, 2020, Page(s) e035343, ISSN 2044-6055
DOI: 10.1136/bmjopen-2019-035343
Author(s): Esther Willems, Wynand Alkema, Jenneke Keizer-Garritsen, Anouk Suppers, Michiel van der Flier, Ria H.L.A. Philipsen, Lambert P. van den Heuvel, Elena Volokhina, Renate G. van der Molen, Jethro A. Herberg, Michael Levin, Victoria J. Wright, Inge M.L. Ahout, Gerben Ferwerda, Marieke Emonts, Navin P. Boeddha, Irene Rivero-Calle, Federico Martinon Torres, Hans J.C.T. Wessels, Ronald de Groot, Alain J.
Published in: EBioMedicine, Issue 45, 2019, Page(s) 303-313, ISSN 2352-3964
DOI: 10.1016/j.ebiom.2019.06.008
Author(s): Juan Emmanuel Dewez, Ruud Gerard Nijman, Shunmay Yeung
Published in: Archives of Disease in Childhood, Issue 104/12, 2019, Page(s) 1236-1236, ISSN 0003-9888
DOI: 10.1136/archdischild-2019-317595
Author(s): Elizabeth Whittaker, Alasdair Bamford, Julia Kenny, Myrsini Kaforou, Christine E. Jones, Priyen Shah, Padmanabhan Ramnarayan, Alain Fraisse, Owen Miller, Patrick Davies, Filip Kucera, Joe Brierley, Marilyn McDougall, Michael Carter, Adriana Tremoulet, Chisato Shimizu, Jethro Herberg, Jane C. Burns, Hermione Lyall, Michael Levin
Published in: JAMA, 2020, ISSN 0098-7484
DOI: 10.1001/jama.2020.10369
Author(s): Dorine Borensztajn, Shunmay Yeung, Nienke N Hagedoorn, Anda Balode, Ulrich von Both, Enitan D Carrol, Juan Emmanuel Dewez, Irini Eleftheriou, Marieke Emonts, Michiel van der Flier, Ronald de Groot, Jethro Adam Herberg, Benno Kohlmaier, Emma Lim, Ian Maconochie, Federico Martinón-Torres, Ruud Nijman, Marko Pokorn, Franc Strle, Maria Tsolia, Gerald Wendelin, Dace Zavadska, Werner Zenz, Michael Levi
Published in: BMJ Paediatrics Open, Issue 3/1, 2019, Page(s) e000456, ISSN 2399-9772
DOI: 10.1136/bmjpo-2019-000456
Author(s): Nienke N. Hagedoorn, Joany M. Zachariasse, Henriette A. Moll
Published in: Critical Care, Issue 23/1, 2019, ISSN 1364-8535
DOI: 10.1186/s13054-019-2653-9
Author(s): Dorine Borensztajn, Nienke Hagedoorn, Ulrich von Both, Enitan D. Carrol, Manuel Dewez, Marieke Emonts, Michiel van der Flier, Ronald de Groot, Jethro Herberg, Benno Kohlmaier, Emma Lim, Ian Maconochie, Federico Martinon-Torres, Ruud Nijman, Marko Pokorn, Franc Strle, Maria Tsolia, Clementien Vermont, Shunmay Yeung, Dace Zavadska, Werner Zenz, Michael Levin, Henriëtte A Moll
Published in: European Society for Emergency Medicine abstract book, 2019
Author(s): Nienke Hagedoorn, Dorine Borensztajn, Ian Maconochie, Ruud Nijman, Federico Martinon-Torres, Jethro Herberg, Enitan Carrol, Emma Lim, Maria Tsolia, Marieke Emonts, Ronald de Groot, Michiel van der Flier, Werner Zenz, Benno Kohlmaier, Franc Strle, Marko Pokorn, Dace Zavadska, Ulrich von Both, Clementien Vermont, Shunmay Yeung, Michael Levin,
Henriëtte Moll
Published in: European Society for Emergency Medicine abstract book, 2019
