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Personalised Risk assessment in febrile illness to Optimise Real-life Management across the European Union

Deliverables

3rd Annual Meeting Report

These will be prepared following each Annual Meeting, they will include the main topics of discussion during these events, specifically focusing on major progress milestones and results that can have specific interest to major stakeholders and end-users.

Project Handbook

The Project Handbook is to be taken as a collated support document covering all deadlines and procedures related with decision-making structure, financial reporting, corrective actions, and all aspects involved with managing the project. Partners will be provided a copy and it will be periodically reviewed and updated if necessary

Report on Pilot Studies with Quantum Dot Technology

Results of pilot studies detecting multi transcript signatures by quantum dot technology.

Report on results from multi transcript signature detection via electronic sensors

Results of alternative approaches to detect multi transcript signatures using electro sensors. Evaluation of results from studies in collaboration with POC-ID.

All Approvals Package

Copies of all approvals from ethics committees and national or regional ethics boards/bodies/administrations to be submitted to the European commission. These include approvals for transfer of biological samples and data between parties and any third party. Ethics approvals must cover approval of local institutions where samples are collected as well as overall national approval

Impact Model of Diagnostic on Antimicrobial resistance

Conceptual model of impact of diagnostic on antimicrobial resistance

Report on Rna-Seq and Microarray Studies

Summary report on RNAseq and microarray studies for Discovery group

Mid-Term Recruitment Report

Overview of recruitment by study site including numbers, recruiting problems and any measures made to compensate if recruitment delays occurred. (Per study)

2nd Annual Meeting Report

These will be prepared following each Annual Meeting, they will include the main topics of discussion during these events, specifically focusing on major progress milestones and results that can have specific interest to major stakeholders and end-users.

Consent and Child Assent Forms

Copies of consent forms and child assent forms (in each partner language) submitted to confirm compliance with Article 29 workgroup paper WP131 on processing personal data in health records, and confirming that the consent forms cover the right to withdraw from studies including withdrawal of samples and data.

Ethics Review Report

Independent ethics review board submits second report on ethical issues and conduct of the study

4th Final Meeting Report

These will be prepared following each Annual Meeting, they will include the main topics of discussion during these events, specifically focusing on major progress milestones and results that can have specific interest to major stakeholders and end-users.

Tool-server Platforms

Tool-server platforms: allowing computational tools and workflows to be deployed on the integrated data including custom ones developed by project

PERFORM Dissemination & Communnication Strategy

Will outline the approach PERFORM will take towards the communication of its activities and results to relevant audiences, end-users, policy-makers and stakeholders. The document will include the strategic approach the consortium has selected to maximize the effectiveness and impact of its expected outcomes. It will also include all chosen communication channels and platforms to be developed and used across the duration of the project.

Transcriptomic and proteomic signatures of bacterial and viral infections

Report on transcriptomic and proteomic signatures that distinguish bacterial and viral infections in the discovery cohort

Provider, Parent and Costing Studies

Reports on provider, parent and costing studies

Ethics Board Report (Preliminary)

Initial report of independent ethics review board on the documents for patient consent and the procedures for patient data and sample collection and overall ethical procedures submitted

Report on Feasibility and Implementation of Novel Diagnostics

Report on feasibility and implementation assessment of novel diagnostic

Recruitment Completion Review

Completion of recruitment and patient assignment for all prospective studies (BIVABI, BIVA- ED, BIVA-PIC, BIVA-INF and MOFICHE); samples and patient data sent for analysis. Includes report on updating the status of study registry.

report on protein biomarkers

Report on the performance of individual biomarker proteins

selection of platform

report on the selection of platform to develop prototype diagnostic

Transcriptomic Markers for bacterial and viral infections

Report studies of transcriptomic markers to differentiate febrile patients with bacterial and viral infection in the validation cohorts

Models of novel proteomic and genomic markers

Delivery of a range of options based on models on how a novel proteomic or genomic marker would influence patient care flows

report on molecular diagnostics

report on the outcome of molecular bacterial and viral diagnostic studies

Operational Database

Delivery of operational database, housing clinical and laboratory data

1st Annual Meeting Report

These will be prepared following each Annual Meeting, they will include the main topics of discussion during these events, specifically focusing on major progress milestones and results that can have specific interest to major stakeholders and end-users.

Mass Spectrometry Proteomic Analysis

Delivery of Mass spectrometry proteomic analysis on discovery cohort

Clinical Recruitment & Data Collection Documents

Clinical recruitment and data collection documents for all prospective studies (BIVABI, BIVA- ED, BIVA-PIC, BIVA-INF and MOFICHE) finalised and agreed by PERFORM consortium. These documents to include the first study subject approvals package – with the final version of study protocol, registration number in an approved registry, ethics approval for main study site.

PERFORM Website

The project will develop and use a dedicated website to improve engagement with its end-users and stakeholders. It is the aim of the project to keep its website up to date with the latest activities and outcomes, so as to maximize it's impact with regards to the main interested parties.

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Publications

The cost of diagnostic uncertainty: a prospective economic analysis of febrile children attending an NHS emergency department

Author(s): Simon Leigh, Alison Grant, Nicola Murray, Brian Faragher, Henal Desai, Samantha Dolan, Naeema Cabdi, James B. Murray, Yasmin Rejaei, Stephanie Stewart, Karl Edwardson, Jason Dean, Bimal Mehta, Shunmay Yeung, Frans Coenen, Louis W. Niessen, Enitan D. Carrol
Published in: BMC Medicine, Issue 17/1, 2019, ISSN 1741-7015
DOI: 10.1186/s12916-019-1275-z

Integrated Chemometrics and Statistics to Drive Successful Proteomics Biomarker Discovery

Author(s): Anouk Suppers, Alain van Gool, Hans Wessels
Published in: Proteomes, Issue 6/2, 2018, Page(s) 20, ISSN 2227-7382
DOI: 10.3390/proteomes6020020

Clinical practice guidelines for acute otitis media in children: a systematic review and appraisal of European national guidelines

Author(s): Hijiri G Suzuki, Juan Emmanuel Dewez, Ruud G Nijman, Shunmay Yeung
Published in: BMJ Open, Issue 10/5, 2020, Page(s) e035343, ISSN 2044-6055
DOI: 10.1136/bmjopen-2019-035343

Biosynthetic homeostasis and resilience of the complement system in health and infectious disease

Author(s): Esther Willems, Wynand Alkema, Jenneke Keizer-Garritsen, Anouk Suppers, Michiel van der Flier, Ria H.L.A. Philipsen, Lambert P. van den Heuvel, Elena Volokhina, Renate G. van der Molen, Jethro A. Herberg, Michael Levin, Victoria J. Wright, Inge M.L. Ahout, Gerben Ferwerda, Marieke Emonts, Navin P. Boeddha, Irene Rivero-Calle, Federico Martinon Torres, Hans J.C.T. Wessels, Ronald de Groot, Alain J.
Published in: EBioMedicine, Issue 45, 2019, Page(s) 303-313, ISSN 2352-3964
DOI: 10.1016/j.ebiom.2019.06.008

Fluids in the management of sepsis in children: a review of guidelines in the aftermath of the FEAST trial

Author(s): Juan Emmanuel Dewez, Ruud Gerard Nijman, Shunmay Yeung
Published in: Archives of Disease in Childhood, Issue 104/12, 2019, Page(s) 1236-1236, ISSN 0003-9888
DOI: 10.1136/archdischild-2019-317595

Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2

Author(s): Elizabeth Whittaker, Alasdair Bamford, Julia Kenny, Myrsini Kaforou, Christine E. Jones, Priyen Shah, Padmanabhan Ramnarayan, Alain Fraisse, Owen Miller, Patrick Davies, Filip Kucera, Joe Brierley, Marilyn McDougall, Michael Carter, Adriana Tremoulet, Chisato Shimizu, Jethro Herberg, Jane C. Burns, Hermione Lyall, Michael Levin
Published in: JAMA, 2020, ISSN 0098-7484
DOI: 10.1001/jama.2020.10369

Diversity in the emergency care for febrile children in Europe: a questionnaire study

Author(s): Dorine Borensztajn, Shunmay Yeung, Nienke N Hagedoorn, Anda Balode, Ulrich von Both, Enitan D Carrol, Juan Emmanuel Dewez, Irini Eleftheriou, Marieke Emonts, Michiel van der Flier, Ronald de Groot, Jethro Adam Herberg, Benno Kohlmaier, Emma Lim, Ian Maconochie, Federico Martinón-Torres, Ruud Nijman, Marko Pokorn, Franc Strle, Maria Tsolia, Gerald Wendelin, Dace Zavadska, Werner Zenz, Michael Levi
Published in: BMJ Paediatrics Open, Issue 3/1, 2019, Page(s) e000456, ISSN 2399-9772
DOI: 10.1136/bmjpo-2019-000456

A comparison of clinical paediatric guidelines for hypotension with population-based lower centiles: a systematic review

Author(s): Nienke N. Hagedoorn, Joany M. Zachariasse, Henriette A. Moll
Published in: Critical Care, Issue 23/1, 2019, ISSN 1364-8535
DOI: 10.1186/s13054-019-2653-9

A NICE combination predicting hospitalisation at triage

Author(s): Dorine Borensztajn, Nienke Hagedoorn, Ulrich von Both, Enitan D. Carrol, Manuel Dewez, Marieke Emonts, Michiel van der Flier, Ronald de Groot, Jethro Herberg, Benno Kohlmaier, Emma Lim, Ian Maconochie, Federico Martinon-Torres, Ruud Nijman, Marko Pokorn, Franc Strle, Maria Tsolia, Clementien Vermont, Shunmay Yeung, Dace Zavadska, Werner Zenz, Michael Levin, Henriëtte A Moll
Published in: European Society for Emergency Medicine abstract book, 2019

Clinical prediction to target new biomarkers in febrile children at the ED, a European observational study

Author(s): Nienke Hagedoorn, Dorine Borensztajn, Ian Maconochie, Ruud Nijman, Federico Martinon-Torres, Jethro Herberg, Enitan Carrol, Emma Lim, Maria Tsolia, Marieke Emonts, Ronald de Groot, Michiel van der Flier, Werner Zenz, Benno Kohlmaier, Franc Strle, Marko Pokorn, Dace Zavadska, Ulrich von Both, Clementien Vermont, Shunmay Yeung, Michael Levin, Henriëtte Moll
Published in: European Society for Emergency Medicine abstract book, 2019