Skip to main content

Personalised Risk assessment in febrile illness to Optimise Real-life Management across the European Union

Objective

The management of febrile patients is one of the most common and important problems facing healthcare providers. Distinction between bacterial infections and trivial viral infection on clinical grounds is unreliable, and as a result innumerable patients worldwide undergo hospitalization, invasive investigation and are treated with antibiotics for presumed bacterial infection when, in fact, they are suffering from self-resolving viral infection.
We aim to improve diagnosis and management of febrile patients, by application of sophisticated phenotypic, transcriptomic (genomic, proteomic) and bioinformatic approaches to well characterised large-scale, multi-national patient cohorts already recruited with EU funding. We will identify, and validate promising new discriminators of bacterial and viral infection including transcriptomic and clinical phenotypic markers. The most accurate markers distinguishing bacterial and viral infection will be evaluated in prospective cohorts of patients reflecting the different health care settings across European countries. By linking sophisticated new genomic and proteomic approaches to careful clinical phenotyping, and building on pilot data from our previous studies we will develop a comprehensive management plan for febrile patients which can be rolled out in healthcare systems across Europe.

Field of science

  • /natural sciences/biological sciences/microbiology/bacteriology

Call for proposal

H2020-PHC-2015-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 6 373 692

Participants (17)

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
United Kingdom
EU contribution
€ 1 385 703,75
Address
Keppel Street
WC1E 7HT London
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF LIVERPOOL
United Kingdom
EU contribution
€ 989 471
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 799 937,50
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
EU contribution
€ 700 743,75
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne
Activity type
Higher or Secondary Education Establishments
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 970 386,25
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 746 450
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece
EU contribution
€ 350 000
Address
6 Christou Lada Str
10561 Athina
Activity type
Higher or Secondary Education Establishments
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 1 500 000
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
SERVIZO GALEGO DE SAUDE
Spain
EU contribution
€ 1 004 250
Address
Edificio Administrativo San Lázaro
15703 Santiago De Compostela
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
MEDIZINISCHE UNIVERSITAT GRAZ
Austria
EU contribution
€ 899 500
Address
Auenbruggerplatz 2
8036 Graz
Activity type
Higher or Secondary Education Establishments
UNIVERZITETNI KLINICNI CENTER LJUBLJANA
Slovenia
EU contribution
€ 299 375
Address
Zaloska Cesta 002
1000 Ljubljana
Activity type
Higher or Secondary Education Establishments
RIGAS STRADINA UNIVERSITATE
Latvia
EU contribution
€ 299 375
Address
Dzirciema Street 16
1007 Riga
Activity type
Higher or Secondary Education Establishments
UNITED KINGDOM RESEARCH AND INNOVATION
United Kingdom
EU contribution
€ 570 000
Address
Polaris House North Star Avenue
SN2 1FL Swindon
Activity type
Research Organisations
MICROPATHOLOGY LIMITED
United Kingdom
EU contribution
€ 358 681,25
Address
Sir William Lyons Road
CV4 7EZ Coventry
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIOMERIEUX SA
France
EU contribution
€ 400 100
Address
Chemin De L'orme
69280 Marcy L'etoile
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 350 000
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET BERN
Switzerland
EU contribution
€ 0
Address
Hochschulstrasse 6
3012 Bern
Activity type
Higher or Secondary Education Establishments