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Exploiting Protein Complexes that Induce Cell-death

Objective

The formation of specific protein complexes are key events in life-and-death decisions made by cells. Inappropriate decisions underpin a plethora of disease conditions from degenerative diseases to cancer while the role of the complexes in these processes make them important therapeutic targets. Our ability to develop small molecules to target death-inducing protein complexes has been hampered by an inability to measure complex formation in cells in real-time and by the absence of robust high-throughput assays for the discovery of new lead molecules that target these complexes.
The proposed network (EPIC) will address both of these problems by developing new approaches to measure necrosome and apoptosome formation in real-time as well as new high-throughput and high-content screening assays using Fluorescence resonance transfer and split-luciferase technologies.
EPIC will conform with the H2020 work programme by integrating research activity, novel reagents and expertise across Europe and world through the mobility, knowledge transfer and training of experienced and early stage researchers from within and without the EU. EPIC will realise the potential of researchers through the development of new skill-sets, the transfer new skills between academia and industry, and the development of career opportunities for EU ESRs and ERs. A key part of this activity is the mobility of non-EU researchers and the inward transfer of essential knowledge from outside the EU to benefit EU-based research.
Establishment of EPIC through RISE will generate lead molecules with demonstrable utility and knowledge that will underpin applications to national funding agencies to sustain the communal effort beyond the life of the RISE award. It will also generate intellectual property that will enable the network to approach biotech and pharma to form academia-industry partnerships that will further develop small molecule leads as therapeutics.

Field of science

  • /medical and health sciences/clinical medicine/oncology/cancer

Call for proposal

H2020-MSCA-RISE-2015
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

NATIONAL UNIVERSITY OF IRELAND GALWAY
Address
University Road
H91 Galway
Ireland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 405 000

Participants (4)

GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 27 000
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPEFELIPE
Spain
EU contribution
€ 27 000
Address
Calle Eduardo Primo Yufera 3
46012 Valencia
Activity type
Research Organisations
VIB VZW
Belgium
EU contribution
€ 67 500
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
PROTOQSAR 2000 SL
Spain
EU contribution
€ 81 000
Address
C Salvador Ferrandis Luna 45 Pta 23
46018 Valencia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (1)

TARBIAT MODARES UNIVERSITY (INSTRUCTOR'S TRAINING UNIVERSITY)
Iran
Address
Intersection Of Shahid Chamran And Jalal Al Ahmad Highway
14115 175 Tehran
Activity type
Higher or Secondary Education Establishments