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High level Integrated SEnsor for NanoToxicity Screening

High level Integrated SEnsor for NanoToxicity Screening

Objective

The HISENTS vision is to address the problem of the dearth of high-quality tools for nano-safety assessment by introducing an innovative multimodular high throughput screening (HTP) platform including a set of individual modules each representing a critical physiological function connected and integrated in a hierarchical vectorial manner by a microfluidic network. The increase of the capacity to perform nano-safety assessment will be realised by innovative instrumentation developments for HTP and high content analysis (HCA) approaches. Toxicogenomics on chip is also one embedded objective. Our interdisciplinary approach focuses on tools to maximise the read-across and to assess applicable endpoints for advanced risk assessment of nanomaterials (NM). The main goal is thus to establish individual chip-based microfluidic tools as devices for (nano)toxicity screening which can be combined as an on-line HTP platform. Seven different chip-based sensor elements will be developed and hierarchically combined via a flow system to characterise toxicity pathways of NM. The HISENTS platform allows the grouping and identifying of NM. Parallel to the screening, the pathway and interaction of NM in biological organisms will be simulated using the physiologically based pharmacokinetic (PBPK) model. Using the different sensor modules from the molecular to cell to organ level, HISENTS can input quantitative parameters into the PBPK model resulting in an effective pathway analysis for NM and other critical compounds. The developed platform is crucial for realistic nano-safety assessment and will also find extensive application in pharmaceutical screening due to the flexible modifications of the HTP platform. The specific objective is the development of a multimodular HTP platform as new a screening tool for enhancing the efficiency of hazard profiling. Currently, no such flexible, easy-to-use screening platform with flexibly combinable chip-based sensors is available on the market.

Coordinator

UNIVERSITY OF LEEDS

Address

Woodhouse Lane
Ls2 9jt Leeds

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 411 205

Participants (11)

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FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Germany

EU Contribution

€ 899 990

TEL AVIV UNIVERSITY

Israel

EU Contribution

€ 631 875

Blueprint Product Design Ltd

United Kingdom

EU Contribution

€ 500 050

SLOVENSKA TECHNICKA UNIVERZITA V BRATISLAVE

Slovakia

EU Contribution

€ 508 745

TECHNISCHE UNIVERSITAET WIEN

Austria

EU Contribution

€ 368 750

BIOMEDICINSKE CENTRUM SLOVENSKEJ AKADEMIE VIED

Slovakia

EU Contribution

€ 300 000

USTAV EXPERIMENTALNEJ ONKOLOGIE SLOVENSKEJ AKADEMIE VIED

Slovakia

FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA

Spain

EU Contribution

€ 341 250

UNIVERSITAT DES SAARLANDES

Germany

EU Contribution

€ 270 000

UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK

Ireland

EU Contribution

€ 800 960

NORSK INSTITUTT FOR LUFTFORSKNING STIFTELSE

Norway

EU Contribution

€ 300 000

Project information

Grant agreement ID: 685817

Status

Closed project

  • Start date

    1 April 2016

  • End date

    31 March 2019

Funded under:

H2020-EU.2.1.2.2.

  • Overall budget:

    € 6 332 825

  • EU contribution

    € 6 332 825

Coordinated by:

UNIVERSITY OF LEEDS

United Kingdom