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PROMOTING ACTIVE AGEING: FUNCTIONAL NANOSTRUCTURES FOR ALZHEIMER’S DISEASE AT ULTRA-EARLY STAGES.

Deliverables

Dissemination material (version 2)

Transformatio of public deliverables and results into publishable reports to be disseminated through the website conferences and events Project outputs to be disseminated through publications in peerreviewed journals congresses workshops seminars etc Some articles and public deliverables to be disseminated through the CORDIS serviceBesides flyers or brochures or posters to be delivered during events

Handbook on management

Being a long project with 11 partners, it is necessary to elaborate a handbook of management in order every partner to know perfectly the play rules and the way of working.

Regulatory pathway report v1

A regulatory plan for the project will be prepared in order to define the next steps to be followed for the approval of the nanostructures as a diagnostic agent.

Dissemination material (version 1)

Herein it will be transformed public deliverables and results into publishable reports that will be disseminated though the web site, conferences and events. Project outputs will be disseminated through publications in peer-reviewed journals, congresses, workshops, seminars, etc. Some articles and public deliverables will also be disseminated through the CORDIS service. To sum up, it will consist of compilation of articles, flyers, brochures, posters, etc, for project diffusion

Dissemination and communication plan

The dissemination and communication plan will be set up at month 6 of the project and updated at month 18, 36, 54.

Project web site

Design, develop and continuous update of a project website. The web site will have two different sections Public section: which will contain a description of the project (objectives, structure, consortium, agenda, pictures, templates etc) and Private section: only accessible to the project consortium and authorised partners. This private section will serve also as internal communication tool between partners and depositary of documents

Regulatory pathway report v2 (updated from version 1).

The regulatory plan for the project will be updated with the advices obteined from regulatory bodies during the implementation of the project, especially regarding the design of the in-vitro and in-vivo studies

Report of the structural and morphological characterization of theragnostic nanostructures (both non- and GMP-like).

Report where it is explained in detail knowledge of the structural and morphological properties of designed nanostructures and its characterization techniques relevant at the nanoscale level. It is necessary to give the appropriate feedback to the Partners involved in the design and synthesis of these theragnostic nanostructures.

Report on the chemical, morphological, structural and magnetic characterization of theragnostic nanostructures (GMP-like )

Report where it is explained in detail knowledge of the chemical properties of designed nanostructures and its characterization techniques relevant at the nanoscale level It is necessary to give the appropriate feedback to the Partners involved in the design and synthesis of these theragnostic nanostructures

Report on the magnetic characterization of theragnostic nanostructures (both non- and GMP-like).

Report where it is explained in detail knowledge of the physical properties of designed nanostructures and its characterization techniques relevant at the nanoscale level. It is necessary to give the appropriate feedback to the Partners involved in the design and synthesis of these theragnostic nanostructures.

Publications

Astrocytic mitochondrial ROS modulate brain metabolism and mouse behaviour

Author(s): Carlos Vicente-Gutierrez, Nicoló Bonora, Veronica Bobo-Jimenez, Daniel Jimenez-Blasco, Irene Lopez-Fabuel, Emilio Fernandez, Charlene Josephine, Gilles Bonvento, Jose A. Enriquez, Angeles Almeida, Juan P. Bolaños
Published in: Nature Metabolism, 1/2, 2019, Page(s) 201-211, ISSN 2522-5812
Publisher: Nature
DOI: 10.1038/s42255-018-0031-6

Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in mice

Author(s): Olga Burmistrova, Ana Olias-Arjona, Rebeca Lapresa, Daniel Jimenez-Blasco, Tatiana Eremeeva, Dmitry Shishov, Sergei Romanov, Kristina Zakurdaeva, Angeles Almeida, Peter O. Fedichev, Juan P. Bolaños
Published in: Scientific Reports, 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-48196-z

Quantitative Assessment of Age-Associated Alterations in Brain Vasculature in Wild-Type Mice and in Bigenic Mice that Model Alzheimer’s Disease

Author(s): Kristof Govaerts, Tom Dresselaers, Fred Van Leuven, Uwe Himmelreich
Published in: Molecular Imaging and Biology, 22/3, 2020, Page(s) 578-586, ISSN 1536-1632
Publisher: Elsevier BV
DOI: 10.1007/s11307-019-01402-w

The Neuronal Ischemic Tolerance Is Conditioned by the Tp53 Arg72Pro Polymorphism

Author(s): Maria E. Ramos-Araque, Cristina Rodriguez, Rebeca Vecino, Elisa Cortijo Garcia, Mercedes de Lera Alfonso, Mercedes Sanchez Barba, Laura Colàs-Campàs, Francisco Purroy, Juan F. Arenillas, Angeles Almeida, Maria Delgado-Esteban
Published in: Translational Stroke Research, 10/2, 2019, Page(s) 204-215, ISSN 1868-4483
Publisher: Springer Pub. Co.,
DOI: 10.1007/s12975-018-0631-1

Synthesis, characterization and in vitro validation of a magnetic zeolite nanocomposite with T 2 -MRI properties towards theranostic applications

Author(s): Natália Vilaça, Juan Gallo, Rui Fernandes, Francisco Figueiredo, António M. Fonseca, Fátima Baltazar, Isabel C. Neves, Manuel Bañobre-López
Published in: Journal of Materials Chemistry B, 7/21, 2019, Page(s) 3351-3361, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9tb00078j

Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model

Author(s): Lynn van Olst, Daan Verhaege, Marc Franssen, Alwin Kamermans, Bart Roucourt, Sofie Carmans, Ellen Ytebrouck, Susanne M.A. van der Pol, Dennis Wever, Marko Popovic, Roosmarijn E. Vandenbroucke, Tomás Sobrino, Marijn Schouten, Helga E. de Vries
Published in: Neurobiology of Aging, 89, 2020, Page(s) 89-98, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2020.01.003

Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice

Author(s): Sami Gabbouj, Teemu Natunen, Hennariikka Koivisto, Kimmo Jokivarsi, Mari Takalo, Mikael Marttinen, Rebekka Wittrahm, Susanna Kemppainen, Reyhaneh Naderi, Adrián Posado-Fernández, Simo Ryhänen, Petra Mäkinen, Kaisa M.A. Paldanius, Gonçalo Doria, Pekka Poutiainen, Orfeu Flores, Annakaisa Haapasalo, Heikki Tanila, Mikko Hiltunen
Published in: Neurobiology of Aging, 75, 2019, Page(s) 98-108, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2018.11.008

Magnetoliposomes as Contrast Agents for Longitudinal in vivo Assessment of Transplanted Pancreatic Islets in a Diabetic Rat Model

Author(s): Rita Sofia Garcia Ribeiro, Conny Gysemans, João Paulo Monteiro Carvalho Mori da Cunha, Bella B. Manshian, Daniel Jirak, Jan Kriz, Juan Gallo, Manuel Bañobre-López, Tom Struys, Marcel De Cuyper, Chantal Mathieu, Stefaan J. Soenen, Willy Gsell, Uwe Himmelreich
Published in: Scientific Reports, 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-29136-9

Glucocorticoid-mediated modulation of morphological changes associated with aging in microglia

Author(s): Lynn van Olst, Pascal Bielefeld, Carlos P. Fitzsimons, Helga E. de Vries, Marijn Schouten
Published in: Aging Cell, 17/4, 2018, Page(s) e12790, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.12790

Longitudinal assessment of cerebral perfusion and vascular response to hypoventilation in a bigenic mouse model of Alzheimer's disease with amyloid and tau pathology

Author(s): Kristof Govaerts, Benoit Lechat, Tom Struys, Anna Kremer, Peter Borghgraef, Fred Van Leuven, Uwe Himmelreich, Tom Dresselaers
Published in: NMR in Biomedicine, 32/2, 2019, Page(s) e4037, ISSN 0952-3480
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4037

Three-Dimensional Hybrid Mesoporous Scaffolds for Simvastatin Sustained Delivery with in Vitro Cell Compatibility

Author(s): Zulema Vargas-Osorio, Asteria Luzardo-Álvarez, Yolanda Piñeiro, Carlos Vázquez-Vázquez, J. Luis Gómez-Amoza, José Blanco-Méndez, Francisco J. Otero Espinar, José Rivas
Published in: ACS Omega, 4/3, 2019, Page(s) 5496-5508, ISSN 2470-1343
Publisher: ACS publications
DOI: 10.1021/acsomega.8b03676

Multifunctional Superparamagnetic Stiff Nanoreservoirs for Blood Brain Barrier Applications

Author(s): Zulema Vargas-Osorio, Andrés Da Silva-Candal, Yolanda Piñeiro, Ramón Iglesias-Rey, Tomas Sobrino, Francisco Campos, José Castillo, José Rivas
Published in: Nanomaterials, 9/3, 2019, Page(s) 449, ISSN 2079-4991
Publisher: Nanomaterials (Basel)
DOI: 10.3390/nano9030449

Intraarterial route increases the risk of cerebral lesions after mesenchymal cell administration in animal model of ischemia

Author(s): Bárbara Argibay, Jesse Trekker, Uwe Himmelreich, Andrés Beiras, Antonio Topete, Pablo Taboada, María Pérez-Mato, Alba Vieites-Prado, Ramón Iglesias-Rey, José Rivas, Anna M. Planas, Tomás Sobrino, José Castillo, Francisco Campos
Published in: Scientific Reports, 7, 2017, Page(s) 40758, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep40758

Magnetite Nanoparticles for Stem Cell Labeling with High Efficiency and Long-Term in Vivo Tracking

Author(s): Noelia Guldris, Bárbara Argibay, Juan Gallo, Ramón Iglesias-Rey, Enrique Carbó-Argibay, Yury V. Kolen’ko, Francisco Campos, Tomás Sobrino, Laura M. Salonen, Manuel Bañobre-López, José Castillo, José Rivas
Published in: Bioconjugate Chemistry, 28/2, 2016, Page(s) 362-370, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.6b00522

APC/C Cdh1 -Rock2 pathway controls dendritic integrity and memory

Author(s): Verónica Bobo-Jiménez, María Delgado-Esteban, Julie Angibaud, Irene Sánchez-Morán, Antonio de la Fuente, Javier Yajeya, U. Valentin Nägerl, José Castillo, Juan P. Bolaños, Angeles Almeida
Published in: Proceedings of the National Academy of Sciences, 114/17, 2017, Page(s) 4513-4518, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1616024114

Hybrid Nanostructured Magnetite Nanoparticles: From Bio-Detection and Theragnostics to Regenerative Medicine

Author(s): Yolanda Piñeiro, Manuel González Gómez, Lisandra de Castro Alves, Angela Arnosa Prieto, Pelayo García Acevedo, Román Seco Gudiña, Julieta Puig, Carmen Teijeiro, Susana Yáñez Vilar, José Rivas
Published in: Magnetochemistry, 6/1, 2020, Page(s) 4, ISSN 2312-7481
Publisher: Magnetic Nanoparticles
DOI: 10.3390/magnetochemistry6010004

Simultaneous in vivo PET/MRI using fluorine-18 labeled Fe3O4@Al(OH)3 nanoparticles: comparison of nanoparticle and nanoparticle-labeled stem cell distribution

Author(s): Sarah Belderbos, Manuel Antonio González-Gómez, Frederik Cleeren, Jens Wouters, Yolanda Piñeiro, Christophe M. Deroose, An Coosemans, Willy Gsell, Guy Bormans, Jose Rivas, Uwe Himmelreich
Published in: EJNMMI Research, 10/1, 2020, ISSN 2191-219X
Publisher: Springer Berlin
DOI: 10.1186/s13550-020-00655-9

Development of Superparamagnetic Nanoparticles Coated with Polyacrylic Acid and Aluminum Hydroxide as an Efficient Contrast Agent for Multimodal Imaging

Author(s): Manuel Antonio González-Gómez, Sarah Belderbos, Susana Yañez-Vilar, Yolanda Piñeiro, Frederik Cleeren, Guy Bormans, Christophe M. Deroose, Willy Gsell, Uwe Himmelreich, José Rivas
Published in: Nanomaterials, 9/11, 2019, Page(s) 1626, ISSN 2079-4991
Publisher: Frontiers in Nanomaterials for Clinical Imaging and Selective Therapy
DOI: 10.3390/nano9111626

<p>Targeting tumor cells and neovascularization using RGD-functionalized magnetoliposomes</p>

Author(s): Rita Sofia Garcia Ribeiro, Sarah Belderbos, Pierre Danhier, Juan Gallo, Bella Manshian, Bernard Gallez, Manuel Bañobre, Marcel de Cuyper, Stefaan Soenen, Willy Gsell, Uwe Himmelreich
Published in: International Journal of Nanomedicine, Volume 14, 2019, Page(s) 5911-5924, ISSN 1178-2013
Publisher: Int J Nanomedicine
DOI: 10.2147/ijn.s214041

Glucose metabolism links astroglial mitochondria to cannabinoid effects

Author(s): Daniel Jimenez-Blasco, Arnau Busquets-Garcia, Etienne Hebert-Chatelain, Roman Serrat, Carlos Vicente-Gutierrez, Christina Ioannidou, Paula Gómez-Sotres, Irene Lopez-Fabuel, Monica Resch-Beusher, Eva Resel, Dorian Arnouil, Dave Saraswat, Marjorie Varilh, Astrid Cannich, Francisca Julio-Kalajzic, Itziar Bonilla-Del Río, Angeles Almeida, Nagore Puente, Svein Achicallende, Maria-Luz Lopez-Rodriguez,
Published in: Nature, 583/7817, 2020, Page(s) 603-608, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2470-y

Progressive age-dependent motor impairment in human tau P301S overexpressing mice

Author(s): Hennariikka Koivisto, Ellen Ytebrouck, Sofie Carmans, Reyhaneh Naderi, Pasi O. Miettinen, Bart Roucourt, Heikki Tanila
Published in: Behavioural Brain Research, 376, 2019, Page(s) 112158, ISSN 0166-4328
Publisher: Elsevier BV
DOI: 10.1016/j.bbr.2019.112158

In the Siege of Alzheimer´s Castle: Contribution to Immunotherapy

Author(s): Adrián Posado Fernández
Published in: 2018
Publisher: FCT/UNL