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PROMOTING ACTIVE AGEING: FUNCTIONAL NANOSTRUCTURES FOR ALZHEIMER’S DISEASE AT ULTRA-EARLY STAGES.

Deliverables

Handbook on management

Being a long project with 11 partners, it is necessary to elaborate a handbook of management in order every partner to know perfectly the play rules and the way of working.

Regulatory pathway report v1

A regulatory plan for the project will be prepared in order to define the next steps to be followed for the approval of the nanostructures as a diagnostic agent.

Dissemination material (version 1)

Herein it will be transformed public deliverables and results into publishable reports that will be disseminated though the web site, conferences and events. Project outputs will be disseminated through publications in peer-reviewed journals, congresses, workshops, seminars, etc. Some articles and public deliverables will also be disseminated through the CORDIS service. To sum up, it will consist of compilation of articles, flyers, brochures, posters, etc, for project diffusion

Dissemination and communication plan

The dissemination and communication plan will be set up at month 6 of the project and updated at month 18, 36, 54.

Project web site

Design, develop and continuous update of a project website. The web site will have two different sections Public section: which will contain a description of the project (objectives, structure, consortium, agenda, pictures, templates etc) and Private section: only accessible to the project consortium and authorised partners. This private section will serve also as internal communication tool between partners and depositary of documents

Regulatory pathway report v2 (updated from version 1).

The regulatory plan for the project will be updated with the advices obteined from regulatory bodies during the implementation of the project, especially regarding the design of the in-vitro and in-vivo studies

Report of the structural and morphological characterization of theragnostic nanostructures (both non- and GMP-like).

Report where it is explained in detail knowledge of the structural and morphological properties of designed nanostructures and its characterization techniques relevant at the nanoscale level. It is necessary to give the appropriate feedback to the Partners involved in the design and synthesis of these theragnostic nanostructures.

Report on the magnetic characterization of theragnostic nanostructures (both non- and GMP-like).

Report where it is explained in detail knowledge of the physical properties of designed nanostructures and its characterization techniques relevant at the nanoscale level. It is necessary to give the appropriate feedback to the Partners involved in the design and synthesis of these theragnostic nanostructures.

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Publications

In the Siege of Alzheimer´s Castle: Contribution to Immunotherapy

Author(s): Adrián Posado Fernández
Published in: 2018

Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice

Author(s): Sami Gabbouj, Teemu Natunen, Hennariikka Koivisto, Kimmo Jokivarsi, Mari Takalo, Mikael Marttinen, Rebekka Wittrahm, Susanna Kemppainen, Reyhaneh Naderi, Adrián Posado-Fernández, Simo Ryhänen, Petra Mäkinen, Kaisa M.A. Paldanius, Gonçalo Doria, Pekka Poutiainen, Orfeu Flores, Annakaisa Haapasalo, Heikki Tanila, Mikko Hiltunen
Published in: Neurobiology of Aging, Issue 75, 2019, Page(s) 98-108, ISSN 0197-4580
DOI: 10.1016/j.neurobiolaging.2018.11.008

Magnetoliposomes as Contrast Agents for Longitudinal in vivo Assessment of Transplanted Pancreatic Islets in a Diabetic Rat Model

Author(s): Rita Sofia Garcia Ribeiro, Conny Gysemans, João Paulo Monteiro Carvalho Mori da Cunha, Bella B. Manshian, Daniel Jirak, Jan Kriz, Juan Gallo, Manuel Bañobre-López, Tom Struys, Marcel De Cuyper, Chantal Mathieu, Stefaan J. Soenen, Willy Gsell, Uwe Himmelreich
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
DOI: 10.1038/s41598-018-29136-9

Glucocorticoid-mediated modulation of morphological changes associated with aging in microglia

Author(s): Lynn van Olst, Pascal Bielefeld, Carlos P. Fitzsimons, Helga E. de Vries, Marijn Schouten
Published in: Aging Cell, Issue 17/4, 2018, Page(s) e12790, ISSN 1474-9718
DOI: 10.1111/acel.12790

Longitudinal assessment of cerebral perfusion and vascular response to hypoventilation in a bigenic mouse model of Alzheimer's disease with amyloid and tau pathology

Author(s): Kristof Govaerts, Benoit Lechat, Tom Struys, Anna Kremer, Peter Borghgraef, Fred Van Leuven, Uwe Himmelreich, Tom Dresselaers
Published in: NMR in Biomedicine, Issue 32/2, 2019, Page(s) e4037, ISSN 0952-3480
DOI: 10.1002/nbm.4037

Three-Dimensional Hybrid Mesoporous Scaffolds for Simvastatin Sustained Delivery with in Vitro Cell Compatibility

Author(s): Zulema Vargas-Osorio, Asteria Luzardo-Álvarez, Yolanda Piñeiro, Carlos Vázquez-Vázquez, J. Luis Gómez-Amoza, José Blanco-Méndez, Francisco J. Otero Espinar, José Rivas
Published in: ACS Omega, Issue 4/3, 2019, Page(s) 5496-5508, ISSN 2470-1343
DOI: 10.1021/acsomega.8b03676

Multifunctional Superparamagnetic Stiff Nanoreservoirs for Blood Brain Barrier Applications

Author(s): Zulema Vargas-Osorio, Andrés Da Silva-Candal, Yolanda Piñeiro, Ramón Iglesias-Rey, Tomas Sobrino, Francisco Campos, José Castillo, José Rivas
Published in: Nanomaterials, Issue 9/3, 2019, Page(s) 449, ISSN 2079-4991
DOI: 10.3390/nano9030449

Intraarterial route increases the risk of cerebral lesions after mesenchymal cell administration in animal model of ischemia

Author(s): Bárbara Argibay, Jesse Trekker, Uwe Himmelreich, Andrés Beiras, Antonio Topete, Pablo Taboada, María Pérez-Mato, Alba Vieites-Prado, Ramón Iglesias-Rey, José Rivas, Anna M. Planas, Tomás Sobrino, José Castillo, Francisco Campos
Published in: Scientific Reports, Issue 7, 2017, Page(s) 40758, ISSN 2045-2322
DOI: 10.1038/srep40758

Magnetite Nanoparticles for Stem Cell Labeling with High Efficiency and Long-Term in Vivo Tracking

Author(s): Noelia Guldris, Bárbara Argibay, Juan Gallo, Ramón Iglesias-Rey, Enrique Carbó-Argibay, Yury V. Kolen’ko, Francisco Campos, Tomás Sobrino, Laura M. Salonen, Manuel Bañobre-López, José Castillo, José Rivas
Published in: Bioconjugate Chemistry, Issue 28/2, 2016, Page(s) 362-370, ISSN 1043-1802
DOI: 10.1021/acs.bioconjchem.6b00522

APC/C Cdh1 -Rock2 pathway controls dendritic integrity and memory

Author(s): Verónica Bobo-Jiménez, María Delgado-Esteban, Julie Angibaud, Irene Sánchez-Morán, Antonio de la Fuente, Javier Yajeya, U. Valentin Nägerl, José Castillo, Juan P. Bolaños, Angeles Almeida
Published in: Proceedings of the National Academy of Sciences, Issue 114/17, 2017, Page(s) 4513-4518, ISSN 0027-8424
DOI: 10.1073/pnas.1616024114