PROMOTING ACTIVE AGEING: FUNCTIONAL NANOSTRUCTURES FOR ALZHEIMER’S DISEASE AT ULTRA-EARLY STAGES.

Informations projet

PANA

N° de convention de subvention: 686009

DOI

10.3030/686009

Projet clôturé

Date de signature de la CE 4 Mars 2016

Date de début 1 Mars 2016

Date de fin 31 Août 2021

Financé au titre de

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials

Coût total

€ 7 775 972,50

Contribution de l’UE

€ 7 775 972,50

Coordonné par

SERVIZO GALEGO DE SAUDE
Spain

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (10)

Dissemination material (version 2)

Transformatio of public deliverables and results into publishable reports to be disseminated through the website conferences and events Project outputs to be disseminated through publications in peerreviewed journals congresses workshops seminars etc Some articles and public deliverables to be disseminated through the CORDIS serviceBesides flyers or brochures or posters to be delivered during events

Handbook on management

Being a long project with 11 partners, it is necessary to elaborate a handbook of management in order every partner to know perfectly the play rules and the way of working.

Regulatory pathway report v1

A regulatory plan for the project will be prepared in order to define the next steps to be followed for the approval of the nanostructures as a diagnostic agent.

Dissemination material (version 1)

Herein it will be transformed public deliverables and results into publishable reports that will be disseminated though the web site, conferences and events. Project outputs will be disseminated through publications in peer-reviewed journals, congresses, workshops, seminars, etc. Some articles and public deliverables will also be disseminated through the CORDIS service. To sum up, it will consist of compilation of articles, flyers, brochures, posters, etc, for project diffusion

Dissemination and communication plan

The dissemination and communication plan will be set up at month 6 of the project and updated at month 18, 36, 54.

Project web site

Design, develop and continuous update of a project website. The web site will have two different sections Public section: which will contain a description of the project (objectives, structure, consortium, agenda, pictures, templates etc) and Private section: only accessible to the project consortium and authorised partners. This private section will serve also as internal communication tool between partners and depositary of documents

Regulatory pathway report v2 (updated from version 1).

The regulatory plan for the project will be updated with the advices obteined from regulatory bodies during the implementation of the project, especially regarding the design of the in-vitro and in-vivo studies

Report of the structural and morphological characterization of theragnostic nanostructures (both non- and GMP-like).

Report where it is explained in detail knowledge of the structural and morphological properties of designed nanostructures and its characterization techniques relevant at the nanoscale level. It is necessary to give the appropriate feedback to the Partners involved in the design and synthesis of these theragnostic nanostructures.

Report on the chemical, morphological, structural and magnetic characterization of theragnostic nanostructures (GMP-like )

Report where it is explained in detail knowledge of the chemical properties of designed nanostructures and its characterization techniques relevant at the nanoscale level It is necessary to give the appropriate feedback to the Partners involved in the design and synthesis of these theragnostic nanostructures

Report on the magnetic characterization of theragnostic nanostructures (both non- and GMP-like).

Report where it is explained in detail knowledge of the physical properties of designed nanostructures and its characterization techniques relevant at the nanoscale level. It is necessary to give the appropriate feedback to the Partners involved in the design and synthesis of these theragnostic nanostructures.

Publications

Peer reviewed articles (21)

Astrocytic mitochondrial ROS modulate brain metabolism and mouse behaviour

Auteurs: Carlos Vicente-Gutierrez, Nicoló Bonora, Veronica Bobo-Jimenez, Daniel Jimenez-Blasco, Irene Lopez-Fabuel, Emilio Fernandez, Charlene Josephine, Gilles Bonvento, Jose A. Enriquez, Angeles Almeida, Juan P. Bolaños
Publié dans: Nature Metabolism, Numéro 1/2, 2019, Page(s) 201-211, ISSN 2522-5812
Éditeur: Nature
DOI: 10.1038/s42255-018-0031-6

Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in mice

Auteurs: Olga Burmistrova, Ana Olias-Arjona, Rebeca Lapresa, Daniel Jimenez-Blasco, Tatiana Eremeeva, Dmitry Shishov, Sergei Romanov, Kristina Zakurdaeva, Angeles Almeida, Peter O. Fedichev, Juan P. Bolaños
Publié dans: Scientific Reports, Numéro 9/1, 2019, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-019-48196-z

Quantitative Assessment of Age-Associated Alterations in Brain Vasculature in Wild-Type Mice and in Bigenic Mice that Model Alzheimer’s Disease

Auteurs: Kristof Govaerts, Tom Dresselaers, Fred Van Leuven, Uwe Himmelreich
Publié dans: Molecular Imaging and Biology, Numéro 22/3, 2020, Page(s) 578-586, ISSN 1536-1632
Éditeur: Elsevier BV
DOI: 10.1007/s11307-019-01402-w

The Neuronal Ischemic Tolerance Is Conditioned by the Tp53 Arg72Pro Polymorphism

Auteurs: Maria E. Ramos-Araque, Cristina Rodriguez, Rebeca Vecino, Elisa Cortijo Garcia, Mercedes de Lera Alfonso, Mercedes Sanchez Barba, Laura Colàs-Campàs, Francisco Purroy, Juan F. Arenillas, Angeles Almeida, Maria Delgado-Esteban
Publié dans: Translational Stroke Research, Numéro 10/2, 2019, Page(s) 204-215, ISSN 1868-4483
Éditeur: Springer Pub. Co.,
DOI: 10.1007/s12975-018-0631-1

Synthesis, characterization and in vitro validation of a magnetic zeolite nanocomposite with T 2 -MRI properties towards theranostic applications

Auteurs: Natália Vilaça, Juan Gallo, Rui Fernandes, Francisco Figueiredo, António M. Fonseca, Fátima Baltazar, Isabel C. Neves, Manuel Bañobre-López
Publié dans: Journal of Materials Chemistry B, Numéro 7/21, 2019, Page(s) 3351-3361, ISSN 2050-7518
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c9tb00078j

Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model

Auteurs: Lynn van Olst, Daan Verhaege, Marc Franssen, Alwin Kamermans, Bart Roucourt, Sofie Carmans, Ellen Ytebrouck, Susanne M.A. van der Pol, Dennis Wever, Marko Popovic, Roosmarijn E. Vandenbroucke, Tomás Sobrino, Marijn Schouten, Helga E. de Vries
Publié dans: Neurobiology of Aging, Numéro 89, 2020, Page(s) 89-98, ISSN 0197-4580
Éditeur: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2020.01.003

Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice

Auteurs: Sami Gabbouj, Teemu Natunen, Hennariikka Koivisto, Kimmo Jokivarsi, Mari Takalo, Mikael Marttinen, Rebekka Wittrahm, Susanna Kemppainen, Reyhaneh Naderi, Adrián Posado-Fernández, Simo Ryhänen, Petra Mäkinen, Kaisa M.A. Paldanius, Gonçalo Doria, Pekka Poutiainen, Orfeu Flores, Annakaisa Haapasalo, Heikki Tanila, Mikko Hiltunen
Publié dans: Neurobiology of Aging, Numéro 75, 2019, Page(s) 98-108, ISSN 0197-4580
Éditeur: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2018.11.008

Magnetoliposomes as Contrast Agents for Longitudinal in vivo Assessment of Transplanted Pancreatic Islets in a Diabetic Rat Model

Auteurs: Rita Sofia Garcia Ribeiro, Conny Gysemans, João Paulo Monteiro Carvalho Mori da Cunha, Bella B. Manshian, Daniel Jirak, Jan Kriz, Juan Gallo, Manuel Bañobre-López, Tom Struys, Marcel De Cuyper, Chantal Mathieu, Stefaan J. Soenen, Willy Gsell, Uwe Himmelreich
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-29136-9

Glucocorticoid-mediated modulation of morphological changes associated with aging in microglia

Auteurs: Lynn van Olst, Pascal Bielefeld, Carlos P. Fitzsimons, Helga E. de Vries, Marijn Schouten
Publié dans: Aging Cell, Numéro 17/4, 2018, Page(s) e12790, ISSN 1474-9718
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/acel.12790

Longitudinal assessment of cerebral perfusion and vascular response to hypoventilation in a bigenic mouse model of Alzheimer's disease with amyloid and tau pathology

Auteurs: Kristof Govaerts, Benoit Lechat, Tom Struys, Anna Kremer, Peter Borghgraef, Fred Van Leuven, Uwe Himmelreich, Tom Dresselaers
Publié dans: NMR in Biomedicine, Numéro 32/2, 2019, Page(s) e4037, ISSN 0952-3480
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4037

Three-Dimensional Hybrid Mesoporous Scaffolds for Simvastatin Sustained Delivery with in Vitro Cell Compatibility

Auteurs: Zulema Vargas-Osorio, Asteria Luzardo-Álvarez, Yolanda Piñeiro, Carlos Vázquez-Vázquez, J. Luis Gómez-Amoza, José Blanco-Méndez, Francisco J. Otero Espinar, José Rivas
Publié dans: ACS Omega, Numéro 4/3, 2019, Page(s) 5496-5508, ISSN 2470-1343
Éditeur: ACS publications
DOI: 10.1021/acsomega.8b03676

Multifunctional Superparamagnetic Stiff Nanoreservoirs for Blood Brain Barrier Applications

Auteurs: Zulema Vargas-Osorio, Andrés Da Silva-Candal, Yolanda Piñeiro, Ramón Iglesias-Rey, Tomas Sobrino, Francisco Campos, José Castillo, José Rivas
Publié dans: Nanomaterials, Numéro 9/3, 2019, Page(s) 449, ISSN 2079-4991
Éditeur: Nanomaterials (Basel)
DOI: 10.3390/nano9030449

Intraarterial route increases the risk of cerebral lesions after mesenchymal cell administration in animal model of ischemia

Auteurs: Bárbara Argibay, Jesse Trekker, Uwe Himmelreich, Andrés Beiras, Antonio Topete, Pablo Taboada, María Pérez-Mato, Alba Vieites-Prado, Ramón Iglesias-Rey, José Rivas, Anna M. Planas, Tomás Sobrino, José Castillo, Francisco Campos
Publié dans: Scientific Reports, Numéro 7, 2017, Page(s) 40758, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/srep40758

Magnetite Nanoparticles for Stem Cell Labeling with High Efficiency and Long-Term in Vivo Tracking

Auteurs: Noelia Guldris, Bárbara Argibay, Juan Gallo, Ramón Iglesias-Rey, Enrique Carbó-Argibay, Yury V. Kolen’ko, Francisco Campos, Tomás Sobrino, Laura M. Salonen, Manuel Bañobre-López, José Castillo, José Rivas
Publié dans: Bioconjugate Chemistry, Numéro 28/2, 2016, Page(s) 362-370, ISSN 1043-1802
Éditeur: American Chemical Society
DOI: 10.1021/acs.bioconjchem.6b00522

APC/C Cdh1 -Rock2 pathway controls dendritic integrity and memory

Auteurs: Verónica Bobo-Jiménez, María Delgado-Esteban, Julie Angibaud, Irene Sánchez-Morán, Antonio de la Fuente, Javier Yajeya, U. Valentin Nägerl, José Castillo, Juan P. Bolaños, Angeles Almeida
Publié dans: Proceedings of the National Academy of Sciences, Numéro 114/17, 2017, Page(s) 4513-4518, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.1616024114

Hybrid Nanostructured Magnetite Nanoparticles: From Bio-Detection and Theragnostics to Regenerative Medicine

Auteurs: Yolanda Piñeiro, Manuel González Gómez, Lisandra de Castro Alves, Angela Arnosa Prieto, Pelayo García Acevedo, Román Seco Gudiña, Julieta Puig, Carmen Teijeiro, Susana Yáñez Vilar, José Rivas
Publié dans: Magnetochemistry, Numéro 6/1, 2020, Page(s) 4, ISSN 2312-7481
Éditeur: Magnetic Nanoparticles
DOI: 10.3390/magnetochemistry6010004

Simultaneous in vivo PET/MRI using fluorine-18 labeled Fe3O4@Al(OH)3 nanoparticles: comparison of nanoparticle and nanoparticle-labeled stem cell distribution

Auteurs: Sarah Belderbos, Manuel Antonio González-Gómez, Frederik Cleeren, Jens Wouters, Yolanda Piñeiro, Christophe M. Deroose, An Coosemans, Willy Gsell, Guy Bormans, Jose Rivas, Uwe Himmelreich
Publié dans: EJNMMI Research, Numéro 10/1, 2020, ISSN 2191-219X
Éditeur: Springer Berlin
DOI: 10.1186/s13550-020-00655-9

Development of Superparamagnetic Nanoparticles Coated with Polyacrylic Acid and Aluminum Hydroxide as an Efficient Contrast Agent for Multimodal Imaging

Auteurs: Manuel Antonio González-Gómez, Sarah Belderbos, Susana Yañez-Vilar, Yolanda Piñeiro, Frederik Cleeren, Guy Bormans, Christophe M. Deroose, Willy Gsell, Uwe Himmelreich, José Rivas
Publié dans: Nanomaterials, Numéro 9/11, 2019, Page(s) 1626, ISSN 2079-4991
Éditeur: Frontiers in Nanomaterials for Clinical Imaging and Selective Therapy
DOI: 10.3390/nano9111626

<p>Targeting tumor cells and neovascularization using RGD-functionalized magnetoliposomes</p>

Auteurs: Rita Sofia Garcia Ribeiro, Sarah Belderbos, Pierre Danhier, Juan Gallo, Bella Manshian, Bernard Gallez, Manuel Bañobre, Marcel de Cuyper, Stefaan Soenen, Willy Gsell, Uwe Himmelreich
Publié dans: International Journal of Nanomedicine, Numéro Volume 14, 2019, Page(s) 5911-5924, ISSN 1178-2013
Éditeur: Int J Nanomedicine
DOI: 10.2147/ijn.s214041

Glucose metabolism links astroglial mitochondria to cannabinoid effects

Auteurs: Daniel Jimenez-Blasco, Arnau Busquets-Garcia, Etienne Hebert-Chatelain, Roman Serrat, Carlos Vicente-Gutierrez, Christina Ioannidou, Paula Gómez-Sotres, Irene Lopez-Fabuel, Monica Resch-Beusher, Eva Resel, Dorian Arnouil, Dave Saraswat, Marjorie Varilh, Astrid Cannich, Francisca Julio-Kalajzic, Itziar Bonilla-Del Río, Angeles Almeida, Nagore Puente, Svein Achicallende, Maria-Luz Lopez-Rodriguez,
Publié dans: Nature, Numéro 583/7817, 2020, Page(s) 603-608, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-020-2470-y

Progressive age-dependent motor impairment in human tau P301S overexpressing mice

Auteurs: Hennariikka Koivisto, Ellen Ytebrouck, Sofie Carmans, Reyhaneh Naderi, Pasi O. Miettinen, Bart Roucourt, Heikki Tanila
Publié dans: Behavioural Brain Research, Numéro 376, 2019, Page(s) 112158, ISSN 0166-4328
Éditeur: Elsevier BV
DOI: 10.1016/j.bbr.2019.112158

Thesis and dissertations (1)

In the Siege of Alzheimer´s Castle: Contribution to Immunotherapy

Auteurs: Adrián Posado Fernández
Publié dans: 2018
Éditeur: FCT/UNL