Objective
Demographic analyses predict that one third of the 10 millions Belgian population in 2050 will be above 60 years of age. Since aging is the major risk factor for Alzheimer’s disease (AD), this increase in the proportion of seniors is closely linked to the increased prevalence of AD. With the advent of promising symptomatic treatment, it is critical to diagnose AD at its earliest stages, that is, before behavioral consequences of cognitive deficits. A systematic assessment of the cognitive state of older adults might be a promising strategy to uncover, as early as possible, individuals at higher risk of pathological aging.
However, this approach raises an important issue: attentional, comprehension, decisional or motivational processes are likely to affect behavioral performance in conventional neuropsychological tests used for the diagnostic, both in AD or typical elderly individuals. The aim of this project is to develop implicit measures of memory encoding for the early diagnosis of AD that are not contaminated by non-mnesic factors. We will use an entirely novel paradigm in electroencephalography: the Fast Periodic Visual Stimulation (FPVS), which relies on the exact synchronization of the human brain to a visual stimulus repeated at a periodic rate. We will apply the FPVS approach to identify early deficits in visual memory encoding/storage in aged individuals. This will be achieved by comparing electrophysiological measures of healthy elderly with and without neuropsychological deficits, and MCI/AD patients. We will perform longitudinal assessments of implicit measures of visual discrimination and memory encoding, to evaluate the test-retest reliability of implicit measures and to examine the sensibility of implicit measures to predict the risk of evolution from MCI to AD. Implicit measures of memory encoding will be correlated with neuroimaging data and biomarkers of AD.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology cognitive neuroscience
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences computer and information sciences artificial intelligence computer vision facial recognition
- social sciences sociology social issues social inequalities
- medical and health sciences basic medicine pathology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1348 LOUVAIN LA NEUVE
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.