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Regulation of DNA interstrand crosslink repair by ubiquitin.

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Publications

Allosteric mechanism for site-specific ubiquitination of FANCD2

Author(s): Viduth K. Chaugule, Connor Arkinson, Martin L. Rennie, Outi Kämäräinen, Rachel Toth, Helen Walden
Published in: Nature Chemical Biology, Issue 16/3, 2020, Page(s) 291-301, ISSN 1552-4450
DOI: 10.1038/s41589-019-0426-z

Characterization of FANCL variants observed in patient cancer cells

Author(s): Mark G. Frost, Amir Mahdi Mazloumi Aboukheili, Rachel Toth, Helen Walden
Published in: Bioscience Reports, Issue 40/6, 2020, ISSN 0144-8463
DOI: 10.1042/bsr20191304

Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements

Author(s): Francesca E. Morreale, Andrea Testa, Viduth K. Chaugule, Alessio Bortoluzzi, Alessio Ciulli, Helen Walden
Published in: Journal of Medicinal Chemistry, Issue 60/19, 2017, Page(s) 8183-8191, ISSN 0022-2623
DOI: 10.1021/acs.jmedchem.7b01071

Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening

Author(s): Francesca E. Morreale, Alessio Bortoluzzi, Viduth K. Chaugule, Connor Arkinson, Helen Walden, Alessio Ciulli
Published in: Journal of Medicinal Chemistry, Issue 60/9, 2017, Page(s) 4093-4098, ISSN 0022-2623
DOI: 10.1021/acs.jmedchem.7b00147

Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1

Author(s): Connor Arkinson, Viduth K Chaugule, Rachel Toth, Helen Walden
Published in: Life Science Alliance, Issue 1/5, 2018, Page(s) e201800162, ISSN 2575-1077
DOI: 10.26508/lsa.201800162

Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA

Author(s): Martin L Rennie, Kimon Lemonidis, Connor Arkinson, Viduth K Chaugule, Mairi Clarke, James Streetley, Laura Spagnolo, Helen Walden
Published in: EMBO reports, Issue 21/7, 2020, ISSN 1469-221X
DOI: 10.15252/embr.202050133

Enzymatic preparation of monoubiquitinated FANCD2 and FANCI proteins

Author(s): Viduth K. Chaugule, Connor Arkinson, Rachel Toth, Helen Walden
Published in: Ubiquitin and Ubiquitin-like Protein Modifiers, Issue 618, 2019, Page(s) 73-104
DOI: 10.1016/bs.mie.2018.12.021