Regulation of DNA interstrand crosslink repair by ubiquitin.

Project Information

ICLUb

Grant agreement ID: 681582

DOI

10.3030/681582

Project closed

EC signature date 10 May 2016

Start date 1 September 2016

End date 31 August 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 998,00

EU contribution

€ 1 999 998,00

Coordinated by

UNIVERSITY OF GLASGOW
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

Allosteric mechanism for site-specific ubiquitination of FANCD2

Author(s): Viduth K. Chaugule, Connor Arkinson, Martin L. Rennie, Outi Kämäräinen, Rachel Toth, Helen Walden
Published in: Nature Chemical Biology, Issue 16/3, 2020, Page(s) 291-301, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-019-0426-z

Mechanism, specificity, and function of FANCD2‐FANCI ubiquitination and deubiquitination

Author(s): Kimon Lemonidis, Connor Arkinson, Martin L. Rennie, Helen Walden
Published in: The FEBS Journal, 2021, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.16077

Characterization of FANCL variants observed in patient cancer cells

Author(s): Mark G. Frost, Amir Mahdi Mazloumi Aboukheili, Rachel Toth, Helen Walden
Published in: Bioscience Reports, Issue 40/6, 2020, ISSN 0144-8463
Publisher: Kluwer Academic Publishers
DOI: 10.1042/bsr20191304

Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements

Author(s): Francesca E. Morreale, Andrea Testa, Viduth K. Chaugule, Alessio Bortoluzzi, Alessio Ciulli, Helen Walden
Published in: Journal of Medicinal Chemistry, Issue 60/19, 2017, Page(s) 8183-8191, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.7b01071

Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening

Author(s): Francesca E. Morreale, Alessio Bortoluzzi, Viduth K. Chaugule, Connor Arkinson, Helen Walden, Alessio Ciulli
Published in: Journal of Medicinal Chemistry, Issue 60/9, 2017, Page(s) 4093-4098, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.7b00147

Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1

Author(s): Connor Arkinson, Viduth K Chaugule, Rachel Toth, Helen Walden
Published in: Life Science Alliance, Issue 1/5, 2018, Page(s) e201800162, ISSN 2575-1077
Publisher: EMBO Press
DOI: 10.26508/lsa.201800162

Structural basis of FANCD2 deubiquitination by USP1−UAF1

Author(s): Martin L. Rennie, Connor Arkinson, Viduth K. Chaugule, Rachel Toth, Helen Walden
Published in: Nature Structural & Molecular Biology, Issue 28/4, 2021, Page(s) 356-364, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-021-00576-8

Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA

Author(s): Martin L Rennie, Kimon Lemonidis, Connor Arkinson, Viduth K Chaugule, Mairi Clarke, James Streetley, Laura Spagnolo, Helen Walden
Published in: EMBO reports, Issue 21/7, 2020, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.202050133