Objective
Lignocellulose is the most abundant organic matter on Earth and important constituent of agricultural and industrial wastes. Lignocellulose-derived monomeric sugars and aromatic compounds can serve as a cheap substrates for biotechnological production of numerous value-added chemicals (VAC). However, a well-defined bacterial platform that could efficiently utilize lignocellulose for biosynthesis of VAC in a single step is still missing. The saprophytic bacterium Pseudomonas putida KT2440, a robust laboratory workhorse with versatile metabolism, has wide potential to utilize lignocellulose-derived sugars and aromatics for VAC formation. But the need for enzymatic pretreatment of the recalcitrant lignocellulose components hinders the development of a cost-effective processes. This challenge could be solved by expanding the biocatalytic functions of P. putida using cellulosomes, efficient enzymatic nanomachines displayed on the surface of certain cellulolytic microorganisms. Synthetic cellulosomes were successfully engineered in biofuel-generating yeast, but never in a Gram-negative bacterium.
The applicant will adopt state-of-the-art approaches and tools of synthetic biology, systems biology and metabolic engineering in order to construct P. putida displaying designer cellulosomes and forming valuable biopolymers directly from cellulosic waste. This task requires a rational orchestration of distinct physiological features of the host in order to achieve the desired qualities without compromising cell viability. In this context, the study will also propose a roadmap for massive refactoring and enrichment of native metabolic properties of environmental bacteria. Thus, the project will not only allow the applicant to enhance his research skills, but will also contribute to both understanding fundamentals of model biological systems and corporate effort aimed at establishing FUTURE knowledge-based bio-economy in Europe.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences synthetic biology
- natural sciences biological sciences biochemistry biomolecules lipids
- natural sciences chemical sciences organic chemistry aromatic compounds
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
28006 MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.