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CryoEM studies of the spliceosome

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Publications

Structure of a pre-catalytic spliceosome

Author(s): Clemens Plaschka, Pei-Chun Lin, Kiyoshi Nagai
Published in: Nature, 2017, ISSN 0028-0836
DOI: 10.1038/nature22799

Postcatalytic spliceosome structure reveals mechanism of 3′–splice site selection

Author(s): Max E. Wilkinson, Sebastian M. Fica, Wojciech P. Galej, Christine M. Norman, Andrew J. Newman, Kiyoshi Nagai
Published in: Science, Issue 358/6368, 2017, Page(s) 1283-1288, ISSN 0036-8075
DOI: 10.1126/science.aar3729

Structure of a spliceosome remodelled for exon ligation

Author(s): Sebastian M. Fica, Chris Oubridge, Wojciech P. Galej, Max E. Wilkinson, Xiao-Chen Bai, Andrew J. Newman, Kiyoshi Nagai
Published in: Nature, Issue 542/7641, 2017, Page(s) 377-380, ISSN 0028-0836
DOI: 10.1038/nature21078

Prespliceosome structure provides insights into spliceosome assembly and regulation

Author(s): Clemens Plaschka, Pei-Chun Lin, Clément Charenton, Kiyoshi Nagai
Published in: Nature, Issue 559/7714, 2018, Page(s) 419-422, ISSN 0028-0836
DOI: 10.1038/s41586-018-0323-8

A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation

Author(s): Sebastian M. Fica, Chris Oubridge, Max E. Wilkinson, Andrew J. Newman, Kiyoshi Nagai
Published in: Science, 2019, Page(s) eaaw5569, ISSN 0036-8075
DOI: 10.1126/science.aaw5569

Structural Basis of Nuclear pre-mRNA Splicing: Lessons from Yeast

Author(s): Clemens Plaschka, Andrew J. Newman, Kiyoshi Nagai
Published in: Cold Spring Harbor Perspectives in Biology, 2019, Page(s) a032391, ISSN 1943-0264
DOI: 10.1101/cshperspect.a032391

Mechanism of 5′ splice site transfer for human spliceosome activation

Author(s): Clément Charenton, Max E. Wilkinson, Kiyoshi Nagai
Published in: Science, 2019, Page(s) eaax3289, ISSN 0036-8075
DOI: 10.1126/science.aax3289