CryoEM studies of the spliceosome

Project Information

SPLICE3D

Grant agreement ID: 693087

DOI 10.3030/693087

Project closed

EC signature date 24 May 2016

Start date 1 June 2016

End date 30 September 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 069 584,70

EU contribution € 1 069 584,70

Coordinated by

UNITED KINGDOM RESEARCH AND INNOVATION
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Non-peer reviewed articles (5)

Cryo-EM snapshots of the human spliceosome reveal structural adaptions for splicing regulation

Author(s): Sebastian M Fica
Published in: Current Opinion in Structural Biology, Issue 65, 2020, Page(s) 139-148, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2020.06.018

CryoEM structures of spliceosomal complexes reveal the molecular mechanism of pre-mRNA splicing

Author(s): Sjors HW Scheres, Kiyoshi Nagai
Published in: Current Opinion in Structural Biology, Issue 46, 2017, Page(s) 130-139, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2017.08.001

RNA Splicing by the Spliceosome

Author(s): Max E. Wilkinson, Clément Charenton, Kiyoshi Nagai
Published in: Annual Review of Biochemistry, Issue 89/1, 2020, Page(s) 359-388, ISSN 0066-4154
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-091719-064225

Molecular Mechanism and Evolution of Nuclear Pre-mRNA and Group II Intron Splicing: Insights from Cryo-Electron Microscopy Structures.

Author(s): Wojciech P. Galej; Navtej Toor; Andrew J. Newman; Kiyoshi Nagai
Published in: Chemical Reviews, Issue 2, 2018, Page(s) 4156-4176, ISSN 0009-2665
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrev.7b00499

Cryo-electron microscopy snapshots of the spliceosome: structural insights into a dynamic ribonucleoprotein machine

Author(s): Sebastian M Fica, Kiyoshi Nagai
Published in: Nature Structural & Molecular Biology, Issue 24/10, 2017, Page(s) 791-799, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/nsmb.3463

Peer reviewed articles (7)

Structure of a pre-catalytic spliceosome

Author(s): Clemens Plaschka, Pei-Chun Lin, Kiyoshi Nagai
Published in: Nature, 2017, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature22799

Postcatalytic spliceosome structure reveals mechanism of 3′–splice site selection

Author(s): Max E. Wilkinson, Sebastian M. Fica, Wojciech P. Galej, Christine M. Norman, Andrew J. Newman, Kiyoshi Nagai
Published in: Science, Issue 358/6368, 2017, Page(s) 1283-1288, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aar3729

Structure of a spliceosome remodelled for exon ligation

Author(s): Sebastian M. Fica, Chris Oubridge, Wojciech P. Galej, Max E. Wilkinson, Xiao-Chen Bai, Andrew J. Newman, Kiyoshi Nagai
Published in: Nature, Issue 542/7641, 2017, Page(s) 377-380, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature21078

Prespliceosome structure provides insights into spliceosome assembly and regulation

Author(s): Clemens Plaschka, Pei-Chun Lin, Clément Charenton, Kiyoshi Nagai
Published in: Nature, Issue 559/7714, 2018, Page(s) 419-422, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0323-8

A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation

Author(s): Sebastian M. Fica, Chris Oubridge, Max E. Wilkinson, Andrew J. Newman, Kiyoshi Nagai
Published in: Science, 2019, Page(s) eaaw5569, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaw5569

Structural Basis of Nuclear pre-mRNA Splicing: Lessons from Yeast

Author(s): Clemens Plaschka, Andrew J. Newman, Kiyoshi Nagai
Published in: Cold Spring Harbor Perspectives in Biology, 2019, Page(s) a032391, ISSN 1943-0264
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a032391

Mechanism of 5′ splice site transfer for human spliceosome activation

Author(s): Clément Charenton, Max E. Wilkinson, Kiyoshi Nagai
Published in: Science, 2019, Page(s) eaax3289, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aax3289