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CryoEM studies of the spliceosome

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Publications

Cryo-EM snapshots of the human spliceosome reveal structural adaptions for splicing regulation

Author(s): Sebastian M Fica
Published in: Current Opinion in Structural Biology, 65, 2020, Page(s) 139-148, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2020.06.018

CryoEM structures of spliceosomal complexes reveal the molecular mechanism of pre-mRNA splicing

Author(s): Sjors HW Scheres, Kiyoshi Nagai
Published in: Current Opinion in Structural Biology, 46, 2017, Page(s) 130-139, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2017.08.001

RNA Splicing by the Spliceosome

Author(s): Max E. Wilkinson, Clément Charenton, Kiyoshi Nagai
Published in: Annual Review of Biochemistry, 89/1, 2020, Page(s) 359-388, ISSN 0066-4154
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-biochem-091719-064225

Molecular Mechanism and Evolution of Nuclear Pre-mRNA and Group II Intron Splicing: Insights from Cryo-Electron Microscopy Structures.

Author(s): Wojciech P. Galej; Navtej Toor; Andrew J. Newman; Kiyoshi Nagai
Published in: Chemical Reviews, 2, 2018, Page(s) 4156-4176, ISSN 0009-2665
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrev.7b00499

Cryo-electron microscopy snapshots of the spliceosome: structural insights into a dynamic ribonucleoprotein machine

Author(s): Sebastian M Fica, Kiyoshi Nagai
Published in: Nature Structural & Molecular Biology, 24/10, 2017, Page(s) 791-799, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/nsmb.3463

Structure of a pre-catalytic spliceosome

Author(s): Clemens Plaschka, Pei-Chun Lin, Kiyoshi Nagai
Published in: Nature, 2017, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature22799

Postcatalytic spliceosome structure reveals mechanism of 3′–splice site selection

Author(s): Max E. Wilkinson, Sebastian M. Fica, Wojciech P. Galej, Christine M. Norman, Andrew J. Newman, Kiyoshi Nagai
Published in: Science, 358/6368, 2017, Page(s) 1283-1288, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aar3729

Structure of a spliceosome remodelled for exon ligation

Author(s): Sebastian M. Fica, Chris Oubridge, Wojciech P. Galej, Max E. Wilkinson, Xiao-Chen Bai, Andrew J. Newman, Kiyoshi Nagai
Published in: Nature, 542/7641, 2017, Page(s) 377-380, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature21078

Prespliceosome structure provides insights into spliceosome assembly and regulation

Author(s): Clemens Plaschka, Pei-Chun Lin, Clément Charenton, Kiyoshi Nagai
Published in: Nature, 559/7714, 2018, Page(s) 419-422, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0323-8

A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation

Author(s): Sebastian M. Fica, Chris Oubridge, Max E. Wilkinson, Andrew J. Newman, Kiyoshi Nagai
Published in: Science, 2019, Page(s) eaaw5569, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaw5569

Structural Basis of Nuclear pre-mRNA Splicing: Lessons from Yeast

Author(s): Clemens Plaschka, Andrew J. Newman, Kiyoshi Nagai
Published in: Cold Spring Harbor Perspectives in Biology, 2019, Page(s) a032391, ISSN 1943-0264
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a032391

Mechanism of 5′ splice site transfer for human spliceosome activation

Author(s): Clément Charenton, Max E. Wilkinson, Kiyoshi Nagai
Published in: Science, 2019, Page(s) eaax3289, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aax3289